Mosaicism: "survival of the fittest" versus "no embryo left behind"

Fertility and Sterility

Volumn 105, Issue 5, 2016, Pages 1146-1149

  Munné, Santiago ^a   Grifo, James ^b   Wells, Dagan ^a,c  

^a Reprogenetics LLC   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; CHROMOSOME ANALYSIS; CHROMOSOME NUMBER; COMPARATIVE GENOMIC HYBRIDIZATION; CRYOPRESERVATION; EMBRYO TRANSFER; ERROR; HUMAN; IN SITU HYBRIDIZATION; MOSAICISM; NEXT GENERATION SEQUENCING; NIDATION; POLYMERASE CHAIN REACTION; PREGNANCY RATE; PREIMPLANTATION GENETIC DIAGNOSIS; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; REVIEW; SINGLE EMBRYO TRANSFER; TIME TO PREGNANCY; EMBRYOLOGY; EPIDEMIOLOGY; EVIDENCE BASED MEDICINE; FEMALE; GENETIC PREDISPOSITION; GENETICS; PREGNANCY; PROCEDURES; REPRODUCIBILITY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; STATISTICS AND NUMERICAL DATA; UNNECESSARY PROCEDURE;

EVIDENCE-BASED MEDICINE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MOSAICISM; PREGNANCY; PREGNANCY RATE; PREIMPLANTATION DIAGNOSIS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SENSITIVITY AND SPECIFICITY; UNNECESSARY PROCEDURES;

EID: 84956645010     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2016.01.016     Document Type: Editorial

References (5)

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3. D. Wells, K. Kaur, A. Rico, J. Grifo, S. Anderson, J. Sherlock, and et al. Clinical utilization of a rapid low-pass whole-genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation J Med Genet 51 2014 553 562
4. J. Grifo, P. Colls, L. Ribustello, T. Escudero, E. Liu, and S. Munné Why do array-CGH (aCGH) euploid embryos miscarry? Reanalysis by NGS reveals undetected abnormalities which would have prevented 56% of the miscarriages Fertil Steril 104 Suppl 3 2015 e14
5. E. Fragouli, S. Alfarawati, K. Spath, N. Tarozzi, A. Borini, and D. Wells The developmental potential of mosaic embryos Fertil Steril 104 3 Suppl 2015 e96