Potential mechanism underlying the PNPLA3I148M-Hepatic steatosis connection

Hepatology

Volumn 63, Issue 2, 2016, Pages 676-677

  Wu, Jiang Wei ^a   Yang, Hao ^a   Mitchell, Grant A ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ATGL PROTEIN; FAT DROPLET; PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; TRIACYLGLYCEROL LIPASE;

FATTY LIVER; GENE; GENETIC ASSOCIATION; LETTER; LIPOLYSIS; NONHUMAN; PNPLA3 GENE; PRIORITY JOURNAL; ANIMAL; FEMALE; GENETICS; HUMAN; MALE;

ANIMALS; FATTY LIVER; FEMALE; HUMANS; LIPASE; MALE; MEMBRANE PROTEINS;

EID: 84956616385     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27943     Document Type: Letter

References (5)

1. Smagris E, BasuRay S, Li J, Huang Y, Lai KM, Gromada J, et al. Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology 2015;61:108-118.
2. Fuchs CD, Claudel T, Kumari P, Haemmerle G, Pollheimer MJ, Stojakovic T, et al. Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. Hepatology 2012;56:270-280.
3. Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 2006;3:309-319.
4. Chamoun Z, Vacca F, Parton RG, Gruenberg J. PNPLA3/adiponutrin functions in lipid droplet formation. Biol Cell 2013;105:219-233.
5. Guo F, Ma Y, Kadegowda AK, Betters JL, Xie P, Liu G, et al. Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res 2013;54:2109-2120.