The economic promise of delayed aging

Cold Spring Harbor Perspectives in Medicine

Volumn 6, Issue 2, 2016, Pages

  Goldman, Dana ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ARTICLE; CANCER INCIDENCE; COST EFFECTIVENESS ANALYSIS; DISEASE MODEL; ECONOMIC ASPECT; HEALTH CARE COST; HEALTH CARE POLICY; HEALTH CARE QUALITY; HEALTH HAZARD; HEART DISEASE; HUMAN; INCOME; LIFE EXPECTANCY; LIFESPAN; LONGEVITY; MEDICAID; MEDICAL RESEARCH; MEDICARE; NEOPLASM; NONHUMAN; QUALITY ADJUSTED LIFE YEAR; SOCIAL SECURITY; AGED; COST OF ILLNESS; ECONOMICS; FORECASTING; HEALTH ECONOMICS; HEALTH INSURANCE; PHYSIOLOGY; SOCIOECONOMICS; TRENDS; UNITED STATES;

AGED; AGING; COST OF ILLNESS; ECONOMICS, MEDICAL; FORECASTING; HEALTH EXPENDITURES; HUMANS; INSURANCE, HEALTH; LIFE EXPECTANCY; LONGEVITY; MEDICARE; UNITED STATES; VALUE OF LIFE;

EID: 84956606297     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a025072     Document Type: Article

References (37)

1. Bhattacharya J, Cutler DM, Goldman DP, Hurd MD, Joyce GF, Lakdawalla DN, Panis CW, Shang B. 2004. Disability forecasts and future Medicare costs. Front Health Policy Res 7: 75–94.
2. Butler RN, Miller RA, Perry D, Carnes BA, Williams TF, Cassel C, Brody J, Bernard MA, Partridge L, Kirkwood T, et al. 2008. Newmodel of health promotion and disease prevention for the 21st century. BMJ 337: a399.
3. Christensen K, Thinggaard M, Oksuzyan A, Steenstrup T, Andersen-Ranberg K, Jeune B, McGue M, Vaupel JW. 2013. Physical and cognitive functioning of people older than 90 years: A comparison of two Danish cohorts born 10 years apart. Lancet 382: 1507–1513.
4. Crimmins EM, Beltran-Sanchez H. 2011. Mortality and morbidity trends: Is there compression of morbidity? J Gerontol B Psychol Sci Soc Sci 66: 75–86.
5. Cutler DM. 2001. Declining disability among the elderly. Health Affairs 20: 11–27.
6. Experts in Chronic Myeloid Leukemia. 2013. The price of drugs for chronic myeloid leukemia (CML) is a reflection of the unsustainable prices of cancer drugs: From the perspective of a large group of CML experts. Blood 121: 4439–4442.
7. Freedman VA, Crimmins E, Schoeni RF, Spillman BC, Aykan H, Kramarow E, Land K, Lubitz J, Manton L, Martin LG, et al. 2004. Resolving inconsistencies in trends in old-age disability: Report from a technical working group. Demography 41: 417–441.
8. Fries JF. 1980. Aging, natural death, and the compression of morbidity. N Engl J Med 303: 130–135.
9. Fries JF, Koop CE, Beadle CE, Cooper PP, England MJ, Greaves RF, Sokolov JJ, Wright D. 1993. Reducing health care costs by reducing the need and demand for medical services. N Engl J Med 329: 321–325.
10. Gold M, Siegel J, Russell L, Weinstein M. 1996.Cost-effectiveness in health and medicine. Oxford University Press, New York.
11. Goldman DP, Philipson T. 2014. Five myths about cancer care in America. Health Aff (Millwood) 33: 1801–1804.
12. Goldman DP, Shang B, Bhattacharya J, Garber AM, Hurd M, Joyce GF, Lakdawalla DN, Panis C, Shekelle PG. 2005. Consequences of health trends and medical innovation for the future elderly. Health Aff (Millwood) 24: W5-R5–W5-R17.
13. Goldman DP, Cutler D, Rowe JW, Michaud PC, Sullivan J, Peneva D, Olshansky SJ. 2013. Substantial health and economic returns from delayed aging may warrant a new focus formedical research. Health Aff (Millwood) 32: 1698–1705.
14. Hsu T, Ennis M, Hood N, Graham M, Goodwin PJ. 2013. Quality of life in long-term breast cancer survivors. J Clin Oncol 31: 3540–3548.
15. Hulsegge G, Picavet HS, Blokstra A, Nooyens AC, Spijkerman AM, van der Schouw YT, Smit HA, Verschuren WM. 2014. Today’s adult generations are less healthy than their predecessors: Generation shifts in metabolic risk factors: The Doetinchem cohort study. Eur J Prev Cardiol 21: 1134–1144.
16. Jemal A, Siegel R, Xu J, Ward E. 2010. Cancer statistics, 2010. CA Cancer J Clin 60: 277–300.
17. Ketcham JD, Simon KI. 2008. Medicare Part D’s effects on elderly patients’ drug costs and utilization. Am J Manag Care 14: SP14–SP22.
18. Kindig DA, Cheng ER. 2013. Even as mortality fell in most US counties, female mortality nonetheless rose in 42.8 percent of counties from 1992 to 2006. Health Aff (Millwood) 32: 451–458.
19. Kirkland JL. 2013. Translating advances from the basic biology of aging into clinical application. Exp Gerontol 48: 1–5.
20. Kubo M, Kiyohara Y, Kato I, Tanizaki Y, Arima H, Tanaka K, Nakamura H, Okubo K, Iida M. 2003. Trends in the incidence, mortality, and survival rate of cardiovascular disease in a Japanese community: The Hisayama study. Stroke 34: 2349–2354.
21. Lakdawalla DN, Bhattacharya J, Goldman DP. 2004. Are the young becoming more disabled? Health Aff (Millwood) 23: 168–176.
22. Lakdawalla DN, Sun EC, Jena AB, Reyes CM, Goldman DP, Philipson TJ. 2010. An economic evaluation of the war on cancer. J Health Econ 29: 333–346.
23. Lipton RB, Hirsch J, Katz MJ, Wang C, Sanders AE, Verghese J, Barzilai N, Derby CA. 2010. Exceptional parental longevity associated with lower risk of Alzheimer’s disease and memory decline. J Am Geriatr Soc 58: 1043–1049.
24. Lowsky DJ, Olshansky SJ, Bhattacharya J, Goldman DP. 2013. Heterogeneity in healthy aging. J Gerontol A Biol Sci Med Sci 69: 640–649.
25. Manton KG, Corder L, Stallard E. 1997. Chronic disability trends in elderly United States populations: 1982–1994. Proc Natl Acad Sci 94: 2593–2598.
26. Martin GM, Bergman A, Barzilai N. 2007. Genetic determinants of human health span and life span: Progress and new opportunities. PLoS Genet 3: e125.
27. Miller RA. 2002. Extending life: Scientific prospects and political obstacles. Milbank Q 80: 155–174.
28. Olshansky SJ, Goldman DP, Zheng Y, Rowe JW. 2009. Aging in America in the twenty-first century: Demographic forecasts from the MacArthur Foundation Research Network on an Aging Society. Milbank Q 87: 842–862.
29. Sebastiani P, Perls TT. 2012. The genetics of extreme longevity: Lessons from the New England Centenarian Study. Front Genet 3: 277.
30. Shekelle PG, Ortiz E, Newberry SJ, Rich MW, Rhodes SL, Brook RH, Goldman DP. 2005. Identifying potential health care innovations for the future elderly. Health Aff (Millwood) 24: W5-R67–W5-R76.
31. Sierra F, Hadley E, Suzman R, Hodes R. 2009. Prospects for life span extension. Annu Rev Med 60: 457–469.
32. Stevens W, Philipson TJ, Khan ZM, MacEwan JP, Linthicum MT, Goldman DP. 2015. Cancer mortality reductions were greatest among countries where cancer care spending rose the most, 1995–2007. Health Aff (Millwood) 34: 562–570.
33. Sullivan J, Goldman D, Michaud PC, Peneva D. 2013. Online supplement for “Attacking diseases by slowing aging: Health and economic implications. ”University of Southern California, Los Angeles.
34. Sun E, Jena AB, Lakdawalla D, Reyes CM, Philipson T, Goldman D. 2010. The contributions of improved therapy and earlier detection to cancer survival gains, 1988–2000. Forum Health Econ Policy 13: 1–20.
35. Tatar M, Bartke A, Antebi A. 2003. The endocrine regulation of aging by insulin-like signals. Science 299: 1346–1351.
36. Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. 2013. Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities. J Clin Invest 123: 966–972.
37. Vergara M, Smith-Wheelock M, Harper JM, Sigler R, Miller RA. 2004. Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant. J Gerontol A Biol Sci Med Sci 59: 1244–1250.