The impact of the introduction of fidaxomicin on the management of Clostridium difficile infection in seven NHS secondary care hospitals in England: a series of local service evaluations

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 35, Issue 2, 2016, Pages 251-259

  Goldenberg, S D ^a   Brown, S ^b   Edwards, L ^c   Gnanarajah, D ^d   Howard, P ^e   Jenkins, D ^c   Nayar, D ^b   Pasztor, M ^f   Oliver, S ^g   Planche, T ^h   Sandoe, J A T ^e   Wade, P ^a   Whitney, L ^h  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^b Bunny Hill Primary Care Centre   (United Kingdom)

^c UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^d DERBY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^f UNIVERSITY HOSPITALS OF MORECAMBE BAY NHS FOUNDATION TRUST   (United Kingdom)

^g PH ASSOCIATES   (United Kingdom)

^h ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; FIDAXOMICIN; PROTON PUMP INHIBITOR; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT;

ADULT; AGED; ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CLINICAL PRACTICE; CLOSTRIDIUM DIFFICILE INFECTION; DIARRHEA; DISEASE RE-EMERGENCE; FEMALE; HEALTH CARE DELIVERY; HEALTH SERVICE; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MANAGED CARE; MEDICAL RECORD; MORTALITY; MULTICENTER STUDY; NATIONAL HEALTH SERVICE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT DISEASE; RETROSPECTIVE STUDY; SECONDARY HEALTH CARE; TIME TO TREATMENT; TREATMENT DURATION; TREATMENT INDICATION; UNITED KINGDOM; CLOSTRIDIUM INFECTIONS; DRUG EFFECTS; ENGLAND; HOSPITAL READMISSION; MICROBIOLOGY; MIDDLE AGED; PEPTOCLOSTRIDIUM DIFFICILE; SECONDARY CARE CENTER; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DIARRHEA; ENGLAND; FEMALE; HUMANS; MALE; MIDDLE AGED; MORTALITY; PATIENT READMISSION; RECURRENCE; RETROSPECTIVE STUDIES; SECONDARY CARE; SECONDARY CARE CENTERS;

EID: 84955759665     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-015-2538-z     Document Type: Article

References (19)

1. Aguado JM, Anttila VJ, Galperine T et al; CDI Consensus Consortium (2015) Highlighting clinical needs in Clostridium difficile infection: the views of European healthcare professionals at the front line. J Hosp Infect 90:117–125
2. Forster AJ, Taljaard M, Oake N, Wilson K, Roth V, van Walraven C (2012) The effect of hospital-acquired infection with Clostridium difficile on length of stay in hospital. CMAJ 184:37–42
3. van Kleef E, Green N, Goldenberg SD et al (2014) Excess length of stay and mortality due to Clostridium difficile infection: a multi-state modelling approach. J Hosp Infect 88:213–217
4. Murphy CR, Avery TR, Dubberke ER, Huang SS (2012) Frequent hospital readmissions for Clostridium difficile infection and the impact on estimates of hospital-associated C. difficile burden. Infect Control Hosp Epidemiol 33:20–28
5. Zilberberg MD, Shorr AF, Micek ST, Kollef MH (2015) Clostridium difficile recurrence is a strong predictor of 30-day rehospitalization among patients in intensive care. Infect Control Hosp Epidemiol 36:273–279
6. Pépin J, Valiquette L, Cossette B (2005) Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ 173:1037–1042
7. Rao K, Micic D, Natarajan M et al (2015) Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Clin Infect Dis 61:233–241
8. Olsen MA, Yan Y, Reske KA, Zilberberg MD, Dubberke ER (2015) Recurrent Clostridium difficile infection is associated with increased mortality. Clin Microbiol Infect 21:164–170
9. Deshpande A, Pasupuleti V, Thota P et al (2015) Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis. Infect Control Hosp Epidemiol 36:452–460
10. Abou Chakra CN, Pepin J, Sirard S, Valiquette L (2014) Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review. PLoS One 9:e98400
11. Bauer MP, Kuijper EJ, van Dissel JT; European Society of Clinical Microbiology and Infectious Diseases (2009) European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infect 15:1067–1079
12. Louie TJ, Miller MA, Mullane KM et al (2011) Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med 364:422–431
13. Cornely OA, Crook DW, Esposito R et al (2012) Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. Lancet Infect Dis 12:281–289
14. Department of Health (2011) Governance arrangements for research ethics committees: a harmonised edition (updated April 2012). Available online at: https://www.gov.uk/government/publications/health-research-ethics-committees-governance-arrangements. Accessed 24th June 2015
15. Kelly CP, LaMont JT (2008) Clostridium difficile—more difficult than ever. N Engl J Med 359:1932–1940
16. Johnson S (2009) Recurrent Clostridium difficile infection: causality and therapeutic approaches. Int J Antimicrob Agents 33:S33–S36
17. Maguire PA, Taylor IC, Stout RW (1986) Elderly patients in acute medical wards: factors predicting length of stay in hospital. Br Med J (Clin Res Ed) 292:1251–1253
18. Campbell SE, Seymour DG, Primrose WR; ACMEPLUS Project (2004) A systematic literature review of factors affecting outcome in older medical patients admitted to hospital. Age Ageing 33:110–115
19. Jasinarachchi KH, Ibrahim IR, Keegan BC et al (2009) Delayed transfer of care from NHS secondary care to primary care in England: its determinants, effect on hospital bed days, prevalence of acute medical conditions and deaths during delay, in older adults aged 65 years and over. BMC Geriatr 9:4