Organochlorine insecticides DDT and chlordane in relation to survival following breast cancer

International Journal of Cancer

Volumn 138, Issue 3, 2016, Pages 565-575

  Parada, Humberto ^a   Wolff, Mary S ^b   Engel, Lawrence S ^a   White, Alexandra J ^a   Eng, Sybil M ^c   Cleveland, Rebecca J ^d   Khankari, Nikhil K ^e   Teitelbaum, Susan L ^b   Neugut, Alfred I ^c   Gammon, Marilie D ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c Columbia University ^*  (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

breast cancer; chlordane; DDE; DDT; organochlorine compounds; pesticides; survival

Indexed keywords

CHLORDANE; CHLORPHENOTANE; ORGANOCHLORINE INSECTICIDE; INSECTICIDE;

ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; BODY MASS; BREAST CANCER; CANCER MORTALITY; CANCER SURVIVAL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PRIORITY JOURNAL; SURVIVAL RATE; UNITED STATES; WEIGHT GAIN; BREAST TUMOR; MORTALITY; PROPORTIONAL HAZARDS MODEL;

BODY MASS INDEX; BREAST NEOPLASMS; CHLORDAN; DDT; FEMALE; HUMANS; INSECTICIDES; PROPORTIONAL HAZARDS MODELS;

EID: 84955747912     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29806     Document Type: Article

References (61)

1. US EPA. DDT-A brief history and status [Internet]. 2012. Available at: http://www2.epa.gov/ingredients-used-pesticide-products/ddt-brief-history-and-status. (accessed on January 23, 2014).
2. Smith D., Worldwide trends in DDT levels in human breast milk. Int J Epidemiol 1999; 28: 179-88.
3. Carson R., Silent spring. Houghton M. Greenwich, Conn: Fawcett Publications, Inc, 2002.
4. Commission for Environmental Cooperation of North America. DDT no longer used in North America [Internet]. 2003. Available at: http://www3.cec.org/islandora/en/item/1968-ddt-no-longer-used-in-north-america-en.pdf. (accessed on May 13, 2015).
5. Centers for Disease Control and Prevention. Indoor Residual Spraying [Internet]. 2012. Available at: http://www.cdc.gov/malaria/malaria-worldwide/reduction/irs.html, accessed on May 13, 2015.
6. Van den Berg H, Zaim M, Yadav RS, et al., Global trends in the use of insecticides to control vector-borne diseases. Environ Health Perspect 2012; 120: 577-82.
7. Schafer KS, Kegley SE., Persistent toxic chemicals in the US food supply. J Epidemiol Community Health 2002; 56: 813-17.
8. US EPA. Chlordane [Internet]. 2013. Available at: http://www.epa.gov/ttn/atw/hlthef/chlordan.html. (accessed on August 12, 2014).
9. Wolff MS., Half-lives of organochlorines (OCs) in humans. Arch Environ Contam Toxicol 1999; 36: 504.
10. Wolff MS, Britton JA, Teitelbaum SL, et al., Improving organochlorine biomarker models for cancer research. Cancer Epidemiol Biomarkers Prev 2005; 14: 2224-36.
11. Welch RM, Levin W, Conney AH., Estrogenic action of DDT and its analogs. Toxicol Appl Pharmacol 1969; 14: 358-67.
12. Kim TS, Kim CY, Lee HK, et al., Estrogenic activity of persistent organic pollutants and parabens based on the stably transfected human estrogen receptor-α transcriptional activation assay (OECD TG 455). Toxicol Res 2011; 27: 181-4.
13. Kelce WR, Stone CR, Laws SC, et al., Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 1995; 375: 581-5.
14. National Pesticide Information Center. DDT (Technical Fact Sheet) [Internet]. 2000. Available at: http://npic.orst.edu/factsheets/ddttech.pdf. (accessed on March 31, 2014).
15. Stellman SD, Djordjevic MV, Muscat JE, et al., Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. Cancer Epidemiol Biomarkers Prev 1998; 7: 489-96.
16. Wolff MS, Paolo G, Lee EW, et al., Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 1993; 85: 648-52.
17. Romieu I., Breast cancer, lactation history, and serum organochlorines. Am J Epidemiol 2000; 152: 363-70.
18. Krieger N, Wolff MS, Hiatt RA, et al., Breast cancer and serum organochlorines: a prospective study among White, Black, and Asian women. J Natl Cancer Inst 1994; 86: 589-99.
19. Güttes S, Failing K, Neumann K, et al., Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol 1998; 35: 140-7.
20. Charlier C., Breast cancer and serum organochlorine residues. Occup Environ Med 2003; 60: 348-51.
21. Cohn BA, Wolff MS, Cirillo PM, et al., DDT and breast cancer in young women: new data on the significance of age at exposure. Environ Health Perspect 2007; 115: 1406-14.
22. Hunter DJ, Hankinson SE, Laden F, et al., Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 1997; 337: 1253-8.
23. Lõpez-Carrillo L, Blair A, Lõpez-cervantes M, et al., Dichlorodiphenyltrichloroethane serum levels and breast cancer risk: a case-control study from Mexico. Cancer Res 1997; 57: 3728-32.
24. Gammon MD, Wolff MS, Neugut AI, et al., Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood. Cancer Epidemiol Biomarkers Prev 2002; 11: 686-97.
25. Millikan R, DeVoto E, Duell EJ, et al., Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African-American and white women in North Carolina. Cancer Epidemiol Biomarkers Prev 2000; 9: 1233-40.
26. Høyer AP, Grandjean P, Jørgensen T, et al., Organochlorine exposure and risk of breast cancer. Lancet 1998; 352: 1816-20.
27. Engel LS, Hill DA, Hoppin JA, et al., Pesticide use and breast cancer risk among farmers' wives in the agricultural health study. Am J Epidemiol 2005; 161: 121-35.
28. Ingber SZ, Buser MC, Pohl HR, et al., DDT/DDE and breast cancer: a meta-analysis. Regul Toxicol Pharmacol 2013; 67: 421-33.
29. Lõpez-Cervantes M, Torres-Sánchez L, Tobías A, et al., Dichlorodiphenyldichloroethane burden and breast cancer risk: a meta-analysis of the epidemiologic evidence. Environ Health Perspect 2004; 112: 207-14.
30. Interagency Breast Cancer and Environmental Research Coordinating Committee (IBCERCC). Breast Cancer and the Environment. Prioritizing Prevention [Internet]. Research Triangle Park, NC: 2013. Available at: http://www.niehs.nih.gov/about/assets/docs/ibcercc-full-508.pdf. (accessed on May 13, 2015).
31. Cohn BA, Merrill M, La Krigbaum NY, et al., DDT exposure in utero and breast cancer. J Clin Endocrinol Metab 2015; 100: 2865-72.
32. Loomis D, Guyton K, Grosse Y, et al., Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. Lancet 2015; 16: 891-2.
33. Høyer AP, Jørgensen T, Brock JW, et al., Organochlorine exposure and breast cancer survival. J Clin Epidemiol 2000; 53: 323-30.
34. Høyer AP, Jorgensen T, Rank F, et al., Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested case-control study. BMC Cancer 2001; 1: 8.
35. Høyer AP, Gerdes A-M, Jørgensen T, et al., Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study. Breast Cancer Res Treat 2002; 71: 59-65.
36. Siegel R, Ma J, Zou Z, et al., Cancer statistics, 2014. CA Cancer J Clin 2014; 64: 9-29.
37. Ferlay J, Shin H-R, Bray F, et al., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-917.
38. Gammon MD, Neugut AI, Santella RM, et al., The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat 2002; 74: 235-54.
39. Brock JW, Burse VW, Ashley DL, et al., An improved analysis for chlorinated pesticides and polychlorinated biphenyls (PCBs) in human and bovine sera using solid-phase extraction. J Anal Toxicol 1996; 20: 528-36.
40. Phillips DL, Pirkle JL, Burse VW, et al., Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol 1989; 18: 495-500.
41. Lõpez-Carrillo L, Torres-Sánchez L, Lõpez-Cervantes M, et al., The adipose tissue to serum dichlorodiphenyldichloroethane (DDE) ratio: some methodological considerations. Environ Res 1999; 81: 142-5.
42. Centers for Disease Control and Prevention. National Death Index [Internet]. 2014. Available at: http://www.cdc.gov/nchs/ndi.htm. (accessed on August 12, 2014).
43. Allison P., Survival analysis using SAS: a practical guide, 2nd edn.: SAS Institute, Cary, NC: 2010.
44. Cleveland RJ, Eng SM, Abrahamson PE, et al., Weight gain prior to diagnosis and survival from breast cancer. Cancer Epidemiol Biomarkers Prev 2007; 16: 1803-11.
45. Soerjomataram I, Louwman MWJ, Ribot JG, et al., An overview of prognostic factors for long-term survivors of breast cancer. Breast Cancer Res Treat 2008; 107: 309-30.
46. Greenland S, Pearl J, Robins JM., Causal diagrams for epidemiologic research. Epidemiology 1999; 10: 37-48.
47. Muñoz-de-Toro M, Durando M, Beldoménico PM, et al., Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERα-positive breast carcinomas. Breast Cancer Res 2006; 8: 1-9.
48. Rothman KJ, Greenland S, Lash TL., Modern epidemiology, 3rd edn. Philadelphia, PA: Lippincott, Williams & Wilkins, 2008.
49. Hammond MEH, Hayes DF, Dowsett M, et al., American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med 2010; 134: e48-e72.
50. Bradshaw PT, Stevens J, Khankari N, et al., Cardiovascular disease mortality is higher among long-term breast cancer survivors than among a population-based sample of women without breast cancer: The Long Island Breast Cancer Study. Epidemiology, in press.
51. Muscat JE, Britton JA, Djordjevic MV, et al., Adipose concentrations of organochlorine compounds and breast cancer recurrence in Long Island, New York. Cancer Epidemiol Biomarkers Prev 2003; 12: 1474-8.
52. Zhuang S, Zhang J, Wen Y, et al., Distinct mechanisms of endocrine disruption of DDT-related pesticides toward estrogen receptor α and estrogen-related receptor γ. Environ Toxicol Chem 2012; 31: 2597-605.
53. Endogenous Hormones Breast Cancer Collaborative Group. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003; 95: 1218-26.
54. Casals-Casas C, Desvergne B., Endocrine disruptors: from endocrine to metabolic disruption. Annu Rev Physiol 2011; 73: 135-62.
55. Bradshaw PT, Ibrahim JG, Stevens J, et al., Postdiagnosis change in bodyweight and survival after breast cancer diagnosis. Epidemiology 2012; 23: 320-7.
56. Trivers KF, Gammon MD, Abrahamson PE, et al., Oral contraceptives and survival in breast cancer patients aged 20 to 54 years. Cancer Epidemiol Biomarkers Prev 2007; 16: 1822-7.
57. US DHHS. Toxicological profile for DDT, DDE, and DDD [Internet]. Atlanta, GA: 2002. Available at: http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=81&tid=20. (accessed on April 7, 2013).
58. Dewailly E, Dodin S, Verreault R, et al., High organochlorine body burden in women with estrogen receptor-positive breast cancer. J Natl Cancer Inst 1994; 86: 232-4.
59. Demers A, Ayotte P, Brisson J, et al., Risk and aggressiveness of breast cancer in relation to plasma organochlorine concentrations. Cancer Epidemiol Biomarkers Prev 2000; 9: 161-6.
60. Schug TT, Janesick A, Blumberg B, et al., Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol 2011; 127: 204-15.
61. Wacholder S, Hartge P, Lubin JH, et al., Non-differential misclassification and bias towards the null: a clarification. Occup Env Med 1995; 52: 557-8.