Clinical outcome and predictive factors in the response to splenectomy in elderly patients with primary immune thrombocytopenia: A multicenter retrospective study

Acta Haematologica

Volumn 135, Issue 3, 2016, Pages 162-171

  Park, Young Hoon ^a   Yi, Hyeon Gyu ^a   Kim, Chul Soo ^a   Hong, Junshik ^b   Park, Jinny ^b   Lee, Jae Hoon ^b   Kim, Ho Young ^c   Kim, Hyo Jung ^c   Zang, Dae Young ^c   Kim, Se Hyung ^d   Park, Seong Kyu ^d   Hong, Dae Sik ^d   Lee, Guk Jin ^e   Jin, Jong Youl ^e  

^a Inha University School of Medicine   (South Korea)

^b Gachon University   (South Korea)

^c Hallym University   (South Korea)

^d Soonchunhyang University   (South Korea)

^e The Catholic University of Korea   (South Korea)

Author keywords

Immune thrombocytopenia; Predictive factor; Response; Splenectomy

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNE THROMBOCYTOPENIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT SAFETY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RECURRENCE FREE SURVIVAL; RELAPSE; RETROSPECTIVE STUDY; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT RESPONSE; ADOLESCENT; ADVERSE EFFECTS; AGED; CLINICAL TRIAL; FOLLOW UP; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; PROCEDURES; PROGNOSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECURRENT DISEASE; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PLATELET COUNT; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECURRENCE; RETROSPECTIVE STUDIES; SPLENECTOMY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84955615140     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000442703     Document Type: Article

References (34)

1. Cines DB, Bussel JB, Liebman HA, Luning Prak ET. The ITP syndrome: pathogenic and clinical diversity. Blood 2009; 113: 6511-6521
2. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kuhne T, Ruggeri M, George JN. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009; 113: 2386-2393
3. Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, Cines DB, Gernsheimer TB, Godeau B, Grainger J, Greer I, Hunt BJ, Imbach PA, Lyons G, McMillan R, Rodeghiero F, Sanz MA, Tarantino M, Watson S, Young J, Kuter DJ. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010; 115: 168-186
4. Zoghlami-Rintelen C, Weltermann A, Bittermann C, Kyrle PA, Pabinger I, Lechner K, Wenzi E. Efficacy and safety of splenectomy in adult chronic immune thrombocytopenia. Ann Hematol 2003; 82: 290-294
5. Kojouri K, Vesely SK, Terrell DR, George JN. Splenectomy for adult patients with idiopathic thrombocytopenic purpura: A systematic review to assess long-term platelet count responses, prediction of response, and surgical complications. Blood 2004; 104: 2623-2634
6. Montalvo J, Velazquez D, Pantoja JP, Sierra M, Lopez-Karpovitch X, Herrera MF. Laparoscopic splenectomy for primary immune thrombocytopenia: clinical outcome and prognostic factors. J Laparoendosc Adv Surg Tech A 2014; 24: 466-470
7. Scaramucci L, Giovannini M, Tendas A, Niscola P, de Fabritiis P. Late but effective longterm response to splenectomy in the treatment of immune thrombocytopenia. Blood Res 2013; 48: 297-298
8. Schwartz J, Leber MD, Gillis S, Giunta A, Eldor A, Bussel JB. Long term follow-up after splenectomy performed for immune thrombocytopenic purpura (ITP). Am J Hematol 2003; 72: 94-98
9. Katkhouda N, Grant SW, Mavor E, Friedlander MH, Lord RV, Achanta K, Essani R, Mason R. Predictors of response after laparoscopic splenectomy for immune thrombocytopenic purpura. Surg Endosc 2001; 15: 484-488
10. Mikhael J, Northridge K, Lindquist K, Kessler C, Deuson R, Danese M. Short-term and long-term failure of laparoscopic splenectomy in adult immune thrombocytopenic purpura patients: A systematic review. Am J Hematol 2009; 84: 743-748
11. Frederiksen H, Schmidt K. The incidence of idiopathic thrombocytopenic purpura in adults increases with age. Blood 1999; 94: 909-913
12. Fabris F, Tassan T, Ramon R, Carraro G, Randi ML, Luzzatto G, Moschino P, Girolami A. Age as the major predictive factor of longterm response to splenectomy in immune thrombocytopenic purpura. Br J Haematol 2001; 112: 637-640
13. Gonzalez-Porras JR, Escalante F, Pardal E, Sierra M, Garcia-Frade LJ, Redondo S, Arefi M, Aquilar C, Ortega F, de Cabo E, Fisac RM, Sanz O, Esteban C, Alberca I, Sanchez-Barba M, Santos MT, Fernandez A, Gonzalez-Lopez TJ; Grupo de Trombosis y Hemostasia de Castilla y Leon: Safety and efficacy of splenectomy in over 65-yrs-old patients with immune thrombocytopenia. Eur J Haematol 2013; 91: 236-241
14. Rodeghiero F, Michel M, Gernsheimer T, Ruqqeri M, Blanchette V, Bussel JB, Cines DB, Cooper N, Godeau B, Greinacher A, Imbach P, Khellaf M, Klaassen RJ, Kuhne T, Liebman H, Mazzucconi MG, Newland A, Pabinger I, Tosetto A, Stasi R. Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group. Blood 2013; 121: 2596-2606
15. Portielje JE, Westendorp RG, Kluin-Nelemans HC, Brand A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood 2001; 97: 2549-2554
16. Rijcken E, Mees ST, Bisping G, Krueger K, Bruewer M, Senninger N, Mennigen R. Laparoscopic splenectomy for medically refractory immune thrombocytopenia (ITP): A retrospective cohort study on longtime response predicting factors based on consensus criteria. Int J Surg 2014; 12: 1428-1433
17. Kang CM, Lee JG, Kim KS, Choi JS, Lee WJ, Kim BR, Ko YW, Han JS, Min YH. Long-term follow-up of laparoscopic splenectomy in patients with immune thrombocytopenic purpura. J Korean Med Sci 2007; 22: 420-424
18. Khan LR, Nixon SJ. Laparoscopic splenectomy is a better treatment for adult ITP than steroids - it should be used earlier in patient management. Conclusions of a ten-year follow- up study. Surgeon 2007; 5: 3-4, 6-8
19. Naouri A, Feqhali B, Chabal J, Boulez J, Dechavanne M, Viala JJ, Tissot E. Results of splenectomy for idiopathic thrombocytopenic purpura. Review of 72 cases. Acta Haematol 1993; 89: 200-203
20. Cortelazzo S, Finazzi G, Buelli M, Molteni A, Viero P, Barbui T. High risk of severe bleeding in aged patients with chronic idiopathic thrombocytopenic purpura. Blood 1991; 77: 31-33
21. Han JJ, Baek SK, Kim SY, Cho KS, Yoon HJ. Long-term outcomes of a 5-year follow up of patients with immune thrombocytopenic purpura after splenectomy. Korean J Hematol 2010; 45: 197-204
22. Duperier T, Brody F, Feisher J, Walsh RM, Rosen M, Ponsky J. Predictive factors for successful laparoscopic splenectomy in patients with immune thrombocytopenic purpura. Arch Surg 2004; 139: 61-66
23. Vianelli N, Galli M, de Vivo A, Intermesoli T, Giannini B, Mazzucconi MG, Barbui T, Tura S, Baccaranion M; Gruppo Italiano per lo Studio delle Malattie Ematologiche dell?Adulto: Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long-term results of 402 cases. Haematologica 2005; 90: 72-77
24. Bussel JB, Kuter DJ, Pullarkat V, Lyons RM, Guo M, Nichol JL. Safety and efficacy of longterm treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood 2009; 113: 2161-2171
25. Patel VL, Mahevas M, Lee SY, Stasi R, Cunningham- Rundles S, Godeau B, Kanter J, Neufeld E, Taube T, Ramenghi U, Shenoy S, Ward MJ, Mihatov N, Patel VL, Bierling P, Lesser M, Cooper N, Bussel JB. Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia. Blood 2012; 119: 5989-5995
26. Aleem A. Durability and factors associated with long term response after splenectomy for primary immune thrombocytopenia (ITP) and outcome of relapsed or refractory patients. Platelets 2011; 22: 1-7
27. Ojima H, Kato T, Araki K, Okamura K, Manda R, Hirayama I, Hosouchi Y, Nishida Y, Kuwano H. Factors predicting long-term responses to splenectomy in patients with idiopathic thrombocytopenic purpura. World J Surg 2006; 30: 553-559
28. Liu EH, Dilip CK, Yeh TS, Wu JH, Jan YY, Chen MF. Long-term relapse-free rurvival rate and predictive factors of idiopathic thrombocytopenic purpura in adults undergoing splenectomy. Biomed J 2013; 36: 23-27
29. Lamy T, Moisan A, Dauriac C, Ghandour C, Morice P, Le Prise PY. Splenectomy in idiopathic thrombocytopenic purpura: its correlation with the sequestration of autologous indium-111-labeled platelets. J Nucl Med 1993; 34: 182-186
30. Winde G, Schmid KW, Lugering N, Fischer R, Brandt B, Berns T, Bunte H. Results and prognostic factors of splenectomy in idiopathic thrombocytopenic purpura. J Am Coll Surg 1996; 183: 565-574
31. DiFino SM, Lachant NA, Kirshner JJ, Gottlieb AJ. Adult idiopathic thrombocytopenic purpura. Clinical findings and response to therapy. Am J Med 1980; 69: 430-442
32. Balague C, Vela S, Targarona EM, Gich IJ, Muniz E, D'Ambra A, Pey A, Monllau V, Ascaso E, Martinez C, Garriga J, Trias M. Predictive factors for successful laparoscopic splenectomy in immune thrombocytopenic purpura: study of clinical and laboratory data. Surg Endosc 2006; 20: 1208-1213
33. Brennan MF, Rappeport JM, Moloney WC, Wilson RE. Correlation between response to corticosteroids and splenectomy for adult idiopathic thrombocytopenic purpura. Am J Surg 1975; 129: 490-492
34. Law C, Marcaccio M, Tam P, Heddle N, Kelton JG. High-dose intravenous immune globulin and the response to splenectomy in patients with idiopathic thrombocytopenic purpura. N Engl J Med 1997; 336: 1494-1498