Interspecies complementation of the LuxR family pathway-specific regulator involved in macrolide biosynthesis

Journal of Microbiology and Biotechnology

Volumn 26, Issue 1, 2015, Pages 66-71

  Mo, Sang Joon ^a   Yoon, Yeo Joon ^b  

^a Dankook University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Interspecies complementation; LAL transcriptional regulator; Pikromycin; Polyketide; Streptomyces venezuelae

Indexed keywords

MACROLIDE; PIKROMYCIN; TRANSCRIPTION FACTOR LUXR; ANTIINFECTIVE AGENT; LUXR AUTOINDUCER BINDING PROTEINS; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; FKBN GENE; GENE CLUSTER; GENETIC COMPLEMENTATION; HETEROLOGOUS EXPRESSION; NONHUMAN; PIKD GENE; RAPH GENE; SECONDARY METABOLISM; STREPTOMYCES VENEZUELAE; BIOSYNTHESIS; CLASSIFICATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; MACROLIDES; REPRESSOR PROTEINS; STREPTOMYCES; TRANS-ACTIVATORS;

EID: 84955614985     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1510.10085     Document Type: Article

References (14)

1. Biermam M, Logan R, O’Brien K, Seno ET, Rao RN, Schoner BE. 1992. Plasmids cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116: 43-49.
2. Huang J, Shi J, Molle V, Sohlberg B, Weaver D, Bibb MJ, et al. 2005. Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol. Microbiol. 58: 1276-1287.
3. Jung WS, Jeong SJ, Park SR, Choi CY, Park BC, Park JW, Yoon YJ. 2008. Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae. Appl. Environ. Microbiol. 74: 1972-1979.
4. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA. 2000. Practical Streptomyces Genetics. John Innes Foundation, Norwich, UK.
5. Kitani S, Ikeda H, Sakamoto T, Noguchi S, Nihira T. 2009. Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis. Appl. Microbiol. Biotechnol. 82: 1089-1096.
6. Lambalot RH, Cane DE. 1992. Isolation and characterization of 10-deoxymethynolide produced by Streptomyces venezuelae. J. Antibiot. (Tokyo) 45: 1981-1882.
7. Lee SK, Park JW, Kim JW, Jung WS, Park SR, Choi CY, et al. 2006. Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Nat. Prod. 69: 847-849.
8. MacNeil DJ, Occi JL, Gewain KM, MacNeil T, Gibbons PH, Ruby CL, Danis SJ. 1992. Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase. Gene 115: 119-125.
9. Sambrook J, Russell D. 2001. Molecular Cloning: A Laboratory Manual, 3rd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
10. Schmitt-John T, Engels JE. 1992. Promoter constructions for efficient secretion expression in Streptomyces lividans. Appl. Microbiol. Biotechnol. 36: 493-498.
11. Walker JE, Saraste M, Runswick MJ, Gay NJ. 1982. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1: 945-951.
12. Wilson DJ, Xue Y, Reynolds KA, Sherman DH. 2001. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetis pathway of the Streptomyces venezuelae. J. Bacteriol. 183: 3468-3475.
13. Wu K, Chung L, Revill WP, Katz L, Reeves CD. 2000. The FK520 gene cluster of Streptomyces hygroscopicus v ar. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251: 81-90.
14. Xue Y, Sherman DH. 2001. Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metab. Eng. 3: 15-26.