Outcomes of Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Receiving an Oral Anticoagulant and Dual Antiplatelet Therapy: A Comparison of Clopidogrel Versus Prasugrel from the TRANSLATE-ACS Study

JACC: Cardiovascular Interventions

Volumn 8, Issue 14, 2015, Pages 1880-1889

  Jackson, Larry R ^a   Ju, Christine ^a   Zettler, Marjorie ^b   Messenger, John C ^c   Cohen, David J ^d   Stone, Gregg W ^e   Baker, Brian A ^f   Effron, Mark ^b   Peterson, Eric D ^a   Wang, Tracy Y ^a  

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^b Lilly Corporate Center   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^e NONE   (United States)

^f DAIICHI SANKYO INC   (United States)

Author keywords

bleeding risk; P2Y12 receptor inhibitor agents; triple therapy

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; PRASUGREL; ANTITHROMBOCYTIC AGENT; PURINERGIC P2Y RECEPTOR ANTAGONIST; TICLOPIDINE;

ACUTE HEART INFARCTION; ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; ATRIAL FIBRILLATION; BLEEDING; BODY WEIGHT; CARDIAC PATIENT; CARDIOGENIC SHOCK; CEREBROVASCULAR ACCIDENT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; DRUG ELUTING STENT; DRUG USE; FEMALE; HEART FAILURE; HEART RATE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; COMBINATION DRUG THERAPY; DOSE RESPONSE; FOLLOW UP; HEMORRHAGE; INCIDENCE; MIDDLE AGED; MORTALITY; MYOCARDIAL INFARCTION; ORAL DRUG ADMINISTRATION; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SURVIVAL RATE; TIME FACTOR; TREATMENT OUTCOME; TRENDS; UNITED STATES;

ADMINISTRATION, ORAL; AGED; ASPIRIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PLATELET AGGREGATION INHIBITORS; PRASUGREL HYDROCHLORIDE; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SURVIVAL RATE; TICLOPIDINE; TIME FACTORS; TREATMENT OUTCOME; UNITED STATES;

EID: 84955492481     PISSN: 19368798     EISSN: 18767605     Source Type: Journal    
DOI: 10.1016/j.jcin.2015.08.018     Document Type: Review

References (24)

1. G.W. Reed, and C.P. Cannon Triple oral antithrombotic therapy in atrial fibrillation and coronary artery stenting Clin Cardiol 36 2013 585 594
2. S. Connolly, J. Pogue, R. Hart, et al. for the ACTIVE Writing Group of the ACTIVE Investigators Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial Lancet 367 2006 1903 1912
3. F. Gao, Y.J. Zhou, Z.J. Wang, and et al. Meta-analysis of the combination of warfarin and dual antiplatelet therapy after coronary stenting in patients with indications for chronic oral anticoagulation Int J Cardiol 148 2011 96 101
4. A. Rubboli The risk of bleeding of triple therapy with vitamin K-antagonists, aspirin and clopidogrel after coronary stent implantation: facts and questions J Geriatr Cardiol 8 2011 207 214
5. H.J. Zhao, Z.T. Zheng, Z.H. Wang, and et al. "Triple therapy" rather than "triple threat": a meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment Chest 139 2011 260 270
6. M. Lamberts, G.H. Gislason, J.B. Olesen, and et al. Oral anticoagulation and antiplatelets in atrial fibrillation patients after myocardial infarction and coronary intervention J Am Coll Cardiol 62 2013 981 989
7. A. Rubboli, P. Magnavacchi, P. Guastaroba, and et al. Antithrombotic management and 1-year outcome of patients on oral anticoagulation undergoing coronary stent implantation (from the Registro Regionale Angioplastiche Emilia-Romagna Registry) Am J Cardiol 109 2012 1411 1417
8. G.N. Levine, E.R. Bates, J.C. Blankenship, and et al. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions J Am Coll Cardiol 58 2011 e44 e122
9. S.D. Wiviott, E. Braunwald, C.H. McCabe, and et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes N Engl J Med 357 2007 2001 2015
10. C.T. Chin, T.Y. Wang, K.J. Anstrom, and et al. Treatment with adenosine diphosphate receptor inhibitors-longitudinal assessment of treatment patterns and events after acute coronary syndrome (TRANSLATE-ACS) study design: expanding the paradigm of longitudinal observational research Am Heart J 162 2011 844 851
11. R. Mehran, S.V. Rao, D.L. Bhatt, and et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium Circulation 123 2011 2736 2747
12. The GUSTO Investigators An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction N Engl J Med 329 1993 673 682
13. Wang TY, Anstrom K, Effron MB, et al. TRANSLATE-ACS: a large-scale registry comparing patterns of use and one-year outcomes with prasugrel versus clopidogrel in patients with acute myocardial infarction undergoing percutaneous coronary intervention. Paper presented at: Transcatheter Cardiovascular Therapeutics (TCT) Conference; September 2014; Washington, DC.
14. G.Y. Lip, S. Windecker, K. Huber, and et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) Eur Heart J 35 2014 3155 3179
15. D.R. Holmes Jr., D.J. Kereiakes, N.S. Kleiman, D.J. Moliterno, G. Patti, and C.L. Grines Combining antiplatelet and anticoagulant therapies J Am Coll Cardiol 54 2009 95 109
16. P.P. Karjalainen, P. Porela, A. Ylitalo, and et al. Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting Eur Heart J 28 2007 726 732
17. J.L. Orford, P. Fasseas, S. Melby, and et al. Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation Am Heart J 147 2004 463 467
18. R. Sorensen, M.L. Hansen, S.Z. Abildstrom, and et al. Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data Lancet 374 2009 1967 1974
19. E.L. Fosbol, T.Y. Wang, S. Li, and et al. Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction Am Heart J 163 2012 720 728
20. N. Sarafoff, A. Martischnig, J. Wealer, and et al. Triple therapy with aspirin, prasugrel, and vitamin K antagonists in patients with drug-eluting stent implantation and an indication for oral anticoagulation J Am Coll Cardiol 61 2013 2060 2066
21. T.Y. Wang, L. McCoy, T.D. Henry, and et al. Early post-discharge bleeding and antiplatelet therapy discontinuation among acute myocardial infarction patients treated with percutaneous coronary intervention J Am Coll Cardiol 63 2014 1700 1702
22. M.L. Hansen, R. Sorensen, M.T. Clausen, and et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation Arch Int Med 170 2010 1433 1441
23. W.J. Dewilde, T. Oirbans, F.W. Verheugt, and et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial Lancet 381 2013 1107 1115
24. ClinicalTrials.gov. A study exploring two strategies of rivaroxaban (JNJ39039039; BAY-59-7939) and one of oral vitamin k antagonist in patients with atrial fibrillation who undergo percutaneous coronary intervention (PIONEER AF-PCI). January 29, 2015. Available at: https://clinicaltrials.gov/ct2/show/NCT01830543. Accessed February 2, 2015.