G6PD deficiency: A polymorphism balanced by heterozygote advantage against malaria

The Lancet Haematology

Volumn 2, Issue 10, 2015, Pages e400-e401

  Luzzatto, Lucio ^a,b  

^a Muhimbili Hospital   (Tanzania)

^b ISTITUTO TOSCANO TUMORI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN S; GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

DNA POLYMORPHISM; GENE MUTATION; GENES EXPRESSION; GENOTYPE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HETEROZYGOTE ADVANTAGE; HUMAN; MALARIA; NOTE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; GENETIC POLYMORPHISM; GENETICS; HETEROZYGOTE;

GLUCOSEPHOSPHATE DEHYDROGENASE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HETEROZYGOTE; HUMANS; MALARIA; POLYMORPHISM, GENETIC;

EID: 84955409391     PISSN: None     EISSN: 23523026     Source Type: Journal    
DOI: 10.1016/S2352-3026(15)00191-X     Document Type: Note

References (10)

1. Uyoga S Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children on the coast of Kenya: a case-control and a cohort study. Lancet Haematology 2015, published online Sept 23. http://dx.doi.org/10.1016/S2352-3026(15)00152-0.
2. Luzzatto L, Poggi VE Glucose 6-phosphate dehydrogenase deficiency. Hematology of infancy and childhood 2009, 883-907. Saunders, Philadelphia. S.H. Orkin, D.G. Nathan, D. Ginsburg, T.A. Look, D.E. Fisher, S.E. Lux (Eds.).
3. Beutler E, Yeh M, Fairbanks VF The normal human female as a mosaic of X-chromosome activity: studies using the gene for G6PD deficiency as a marker. Proc Natl Acad Sci USA 1962, 48:9-16.
4. Luzzatto L, Usanga EA, Reddy S Glucose 6-phosphate dehydrogenase deficient red cells: resistance to infection by malarial parasites. Science 1969, 164:839-842.
5. Ruwende C, Khoo SC, Snow RW, et al. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 1995, 376:246-249.
6. Reappraisal of known malaria resistance loci in a large multicenter study. Nat Genet 2014, 46:1197-1204. Malaria Genomic Epidemiology Network.
7. Bienzle U, Ayeni O, Lucas AO, Luzzatto L Glucose-6-phosphate dehydrogenase deficiency and malaria. Greater resistance of females heterozygous for enzyme deficiency and of males with non-deficient variant. Lancet 1972, 299:107-110.
8. Pamba A, Richardson ND, Carter N, et al. Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. Blood 2012, 120:4123-4133.
9. Luzzatto L The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics. Lancet 2010, 376:739-741.
10. Kirkman HN Properties of X-linked alleles during selection. Am J Hum Genet 1966, 18:424-432.