Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model

Stem Cell Reports

Volumn 6, Issue 1, 2016, Pages 9-17

  Plaza Reyes, Alvaro ^a   Petrus Reurer, Sandra ^a,b   Antonsson, Liselotte ^a   Stenfelt, Sonya ^a   Bartuma, Hammurabi ^b   Panula, Sarita ^a   Mader, Theresa ^a   Douagi, Iyadh ^a   André, Helder ^b   Hovatta, Outi ^a,c   Lanner, Fredrik ^a   Kvanta, Anders ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ST ERIK S EYE HOSPITAL   (Sweden)

^c NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

cellular therapy; differentiation; human embryonic stem cells; laminin; optical coherence tomography; rabbit; retinal pigment epithelium; transplantation; xeno free

Indexed keywords

ENDOTHELIN B RECEPTOR; LAMININ; PIGMENT EPITHELIUM DERIVED FACTOR; TRANSCRIPTION FACTOR PAX6; VASCULOTROPIN; CULTURE MEDIUM; LAMININ 11 PROTEIN, HUMAN; XENOBIOTIC AGENT;

ARTICLE; CELL AGGREGATION; CELL DIFFERENTIATION; CELL MATURATION; CELL SUSPENSION; CONTROLLED STUDY; DISEASE MODEL; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINAL PIGMENT EPITHELIAL CELL; RETINAL THICKNESS; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; XENO-FREE CULTURE; ANIMAL; CELL CULTURE TECHNIQUE; CELL LINE; CHEMISTRY; CONFOCAL MICROSCOPY; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; GEOGRAPHIC ATROPHY; METABOLISM; PATHOPHYSIOLOGY; PHARMACOLOGY; PHYSIOLOGY; PROCEDURES; RABBITS AND HARES; RETINAL PIGMENT EPITHELIUM; STEM CELL TRANSPLANTATION; TIME LAPSE IMAGING; TRANSPLANTATION; XENOGRAFT;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CULTURE MEDIA; DISEASE MODELS, ANIMAL; GEOGRAPHIC ATROPHY; HUMAN EMBRYONIC STEM CELLS; HUMANS; LAMININ; MICROSCOPY, CONFOCAL; RABBITS; RETINAL PIGMENT EPITHELIUM; STEM CELL TRANSPLANTATION; TIME-LAPSE IMAGING; TRANSPLANTATION, HETEROLOGOUS; XENOBIOTICS;

EID: 84955401617     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.11.008     Document Type: Article

References (27)

1. S. Aisenbrey, M. Zhang, D. Bacher, J. Yee, W.J. Brunken, and D.D. Hunter Retinal pigment epithelial cells synthesize laminins, including laminin 5, and adhere to them through alpha3- and alpha6-containing integrins Invest. Ophthalmol. Vis. Sci. 47 2006 5537 5544
2. H. Bartuma, S. Petrus-Reurer, M. Aronsson, S. Westman, H. André, and A. Kvanta In vivo imaging of subretinal bleb-induced outer retinal degeneration Invest. Ophthalmol. Vis. Sci. 56 2015 2423 2430
3. I. Bhutto, and G. Lutty Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex Mol. Aspects Med. 33 2012 295 317
4. P.A. Campochiaro, J.A. Jerdon, and B.M. Glaser The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro Invest. Ophthalmol. Vis. Sci. 27 1986 1615 1621
5. M. Carido, Y. Zhu, K. Postel, B. Benkner, P. Cimalla, M.O. Karl, T. Kurth, F. Paquet-Durand, E. Koch, T.A. Munch, and et al. Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation Invest. Ophthalmol. Vis. Sci. 55 2014 5431 5444
6. B. Diniz, P. Thomas, B. Thomas, R. Ribeiro, Y. Hu, R. Brant, A. Ahuja, D. Zhu, L. Liu, M. Koss, and et al. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer Invest. Ophthalmol. Vis. Sci. 54 2013 5087 5096
7. A.A. el Dirini, H.M. Wang, T.E. Ogden, and S.J. Ryan Retinal pigment epithelium implantation in the rabbit: technique and morphology Graefes Arch. Clin. Exp. Ophthalmol. 230 1992 292 300
8. M. Hornof, E. Toropainen, and A. Urtti Cell culture models of the ocular barriers Eur. J. Pharm. Biopharm. 60 2005 207 225
9. M. Idelson, R. Alper, A. Obolensky, E. Ben-Shushan, I. Hemo, N. Yachimovich-Cohen, H. Khaner, Y. Smith, O. Wiser, M. Gropp, and et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells Cell Stem Cell 5 2009 396 408
10. H. Kamao, M. Mandai, S. Okamoto, N. Sakai, A. Suga, S. Sugita, J. Kiryu, and M. Takahashi Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application Stem Cell Rep. 2 2014 205 218
11. I. Klimanskaya, J. Hipp, K.A. Rezai, M. West, A. Atala, and R. Lanza Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics Cloning Stem Cells 6 2004 217 245
12. A. Lane, L.R. Philip, L. Ruban, K. Fynes, M. Smart, A. Carr, C. Mason, and P. Coffey Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells Stem Cells Transl. Med. 3 2014 1295 1304
13. R.D. Lund, S. Wang, I. Klimanskaya, T. Holmes, R. Ramos-Kelsey, B. Lu, S. Girman, N. Bischoff, Y. Sauve, and R. Lanza Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats Cloning Stem Cells 8 2006 189 199
14. M.J. Martin, A. Muotri, F. Gage, and A. Varki Human embryonic stem cells express an immunogenic nonhuman sialic acid Nat. Med. 11 2005 228 232
15. F. Osakada, Z.B. Jin, Y. Hirami, H. Ikeda, T. Danjyo, K. Watanabe, Y. Sasai, and M. Takahashi In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction J. Cell Sci. 122 2009 3169 3179
16. B.O. Pennington, D.O. Clegg, Z.K. Melkoumian, and S.T. Hikita Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate Stem Cells Transl. Med. 4 2015 165 177
17. I. Pinilla, N. Cuenca, G. Martinez-Navarrete, R. Lund, and Y. Sauvé Intraretinal processing following photoreceptor rescue by non-retinal cells Vision Res. 49 2009 2067 2077
18. C. Pittack, G.B. Grunwald, and T.A. Reh Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos Development 124 1997 805 816
19. S. Rodin, L. Antonsson, O. Hovatta, and K. Tryggvason Monolayer culturing and cloning of human pluripotent stem cells on laminin-521-based matrices under xeno-free and chemically defined conditions Nat. Protoc. 9 2014 2354 2368
20. S. Rodin, L. Antonsson, C. Niaudet, O.E. Simonson, E. Salmela, E.M. Hansson, A. Domogatskaya, Z. Xiao, P. Damdimopoulou, M. Sheikhi, and et al. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment Nat. Commun. 5 2014 3195
21. T.J. Rowland, A.J. Blaschke, D.E. Buchholz, S.T. Hikita, L.V. Johnson, and D.O. Clegg Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins J. Tissue Eng. Regen. Med. 7 2013 642 653
22. S.D. Schwartz, J.P. Hubschman, G. Heilwell, V. Franco-Cardenas, C.K. Pan, R.M. Ostrick, E. Mickunas, R. Gay, I. Klimanskaya, and R. Lanza Embryonic stem cell trials for macular degeneration: a preliminary report Lancet 379 2012 713 720
23. S.D. Schwartz, C.D. Regillo, B.L. Lam, D. Eliott, P.J. Rosenfeld, N.Z. Gregori, J.P. Hubschman, J.L. Davis, G. Heilwell, M. Spirn, and et al. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies Lancet 385 2015 509 516
24. J.R. Sparrow, D. Hicks, and C.P. Hamel The retinal pigment epithelium in health and disease Curr. Mol. Med. 10 2010 802 823
25. B.V. Stanzel, Z. Liu, S. Somboonthanakij, W. Wongsawad, R. Brinken, N. Eter, B. Corneo, F.G. Holz, S. Temple, J.H. Stern, and et al. Human RPE stem cells grown into polarized RPE monolayers on a polyester matrix are maintained after grafting into rabbit subretinal space Stem Cell Rep. 2 2014 64 77
26. H. Vaajasaari, T. Ilmarinen, K. Juuti-Uusitalo, K. Rajala, N. Onnela, S. Narkilahti, R. Suuronen, J. Hyttinen, H. Uusitalo, and H. Skottman Toward the defined and xeno-free differentiation of functional human pluripotent stem cell-derived retinal pigment epithelial cells Mol. Vis. 17 2011 558 575
27. A. Vugler, A.J. Carr, J. Lawrence, L.L. Chen, K. Burrell, A. Wright, P. Lundh, M. Semo, A. Ahmado, C. Gias, and et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation Exp. Neurol. 214 2008 347 361