Double trouble: T2DM genetic risk factors play a causal role in CAD

Atherosclerosis

Volumn 241, Issue 2, 2015, Pages 766-768

  Hamad, Ibrahim A Y ^a,b   Beaney, Katherine E ^a   Buxton, Jessica L ^a   Walker, Ann P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b AL AZHAR UNIVERSITY   (Egypt)

Author keywords

CAD; Coronary artery disease; Genetic risk score; Pathogenesis; Single nucleotide polymorphism; SNP; T2D; T2DM; Type 2 diabetes mellitus

Indexed keywords

PROTEIN;

ALLELE; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; OBESITY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SEDENTARY LIFESTYLE; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS; DIABETIC ANGIOPATHY; GENETICS;

CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84955349063     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.03.033     Document Type: Note

References (17)

1. Finegold J.A., Asaria P., Francis D.P. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int. J. Cardiol. 2013 Sep 30, 168(2):934-945.
2. Deloukas P., Kanoni S., Willenborg C., Farrall M., Assimes T.L., Thompson J.R., et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet. 2013 Jan, 45(1):25-33.
3. Lieb W., Vasan R.S. Genetics of coronary artery disease. Circulation 2013 Sep 3, 128(10):1131-1138.
4. Schunkert H., Konig I.R., Kathiresan S., Reilly M.P., Assimes T.L., Holm H., et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 2011 Apr, 43(4):333-338.
5. Qi L., Qi Q., Prudente S., Mendonca C., Andreozzi F., di P.N., et al. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA 2013 Aug 28, 310(8):821-828.
6. Jansen H., et al. Genetic variants primarily associated with type 2 diabetes also affect coronary artery disease risk. Atherosclerosis 2015, 241:419-426.
7. Preuss M., Konig I.R., Thompson J.R., Erdmann J., Absher D., Assimes T.L., et al. Design of the Coronary ARtery DIsease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) Study: a Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ. Cardiovasc. Genet. 2010 Oct, 3(5):475-483.
8. Dawber T.R., Kannel W.B., Revotskie N., Stokes J., Kagan A., Gordon T. Some factors associated with the development of coronary heart disease: six years' follow-up experience in the Framingham study. Am. J. Public Health Nations Health 1959 Oct, 49:1349-1356.
9. Kannel W.B., McGee D.L. Diabetes and cardiovascular disease. The Framingham study. JAMA 1979 May 11, 241(19):2035-2038.
10. Splansky G.L., Corey D., Yang Q., Atwood L.D., Cupples L.A., Benjamin E.J., et al. The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am. J. Epidemiol. 2007 Jun 1, 165(11):1328-1335.
11. Wichmann H.E., Gieger C., Illig T. KORA-gen-resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen 2005 Aug, 67(Suppl. 1):S26-S30.
12. Talmud P.J., Cooper J.A., Morris R.W., Dudbridge F., Shah T., Engmann J., et al. Sixty-five common genetic variants and prediction of type 2 diabetes. Diabetes 2014 Dec 4, (PMID: 25475436). 10.2337/db14-1504.
13. King H., Aubert R.E., Herman W.H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998 Sep, 21(9):1414-1431.
14. Cho Y.S., Chen C.H., Hu C., Long J., Ong R.T., Sim X., et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat. Genet. 2012 Jan, 44(1):67-72.
15. Tabassum R., Chauhan G., Dwivedi O.P., Mahajan A., Jaiswal A., Kaur I., et al. Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes 2013 Mar, 62(3):977-986.
16. Al-Daghri N.M., Alkharfy K.M., Alokail M.S., Alenad A.M., Al-Attas O.S., Mohammed A.K., et al. Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population. Clin. Endocrinol. (Oxf) 2014 Apr, 80(4):532-537.
17. Tekola-Ayele F., Adeyemo A.A., Rotimi C.N. Genetic epidemiology of type 2 diabetes and cardiovascular diseases in Africa. Prog. Cardiovasc. Dis. 2013 Nov, 56(3):251-260.