Metabolomics study of fatigue in patients with rheumatoid arthritis naïve to biological treatment

Rheumatology International

Volumn 36, Issue 5, 2016, Pages 703-711

  Surowiec, Izabella ^a   Gjesdal, Clara Gram ^b,c   Jonsson, Grete ^d   Norheim, Katrine Brække ^d   Lundstedt, Torbjörn ^e   Trygg, Johan ^a   Omdal, Roald ^c,d  

^a UMEÅ UNIVERSITY   (Sweden)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

^d STAVANGER UNIVERSITY HOSPITAL   (Norway)

^e AcureOmics AB   (Sweden)

Author keywords

Fatigue; Metabolomics; Oxidative stress; Rheumatoid arthritis

Indexed keywords

2 OXOISOCAPROIC ACID; ALPHA TOCOPHEROL; ARGININE; AROMATIC AMINO ACID; CYSTINE; DOCOSAHEXAENOIC ACID; EDETIC ACID; FATTY ACID; HEPTADECANOIC ACID; HIPPURIC ACID; HYDROXYPROLINE; HYPOXANTHINE; ISOLEUCINE; LINOLEIC ACID; LYSINE; METHIONINE; METHOTREXATE; OLEIC ACID; ORNITHINE; PALMITIC ACID; PHENYLALANINE; PIPECOLIC ACID; PREDNISOLONE; STEARIC ACID; THREONINE; TOCOPHEROL; TRYPTOPHAN; TYROSINE; URIC ACID; VALINE;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; DISABILITY SEVERITY; DOWN REGULATION; FATIGUE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MALE; METABOLITE; METABOLOMICS; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; UREA CYCLE; URIC ACID BLOOD LEVEL; VISUAL ANALOG SCALE; COMPLICATION; MASS FRAGMENTOGRAPHY; METABOLISM; MIDDLE AGED;

ADULT; AGED; ARTHRITIS, RHEUMATOID; FATIGUE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; METABOLOMICS; MIDDLE AGED;

EID: 84955321704     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-016-3426-2     Document Type: Article

References (44)

1. Kirwan JR, Minnock P, Adebajo A, Bresnhan B, Choy E, De Wit M et al (2007) Patient perspective: fatigue as a recommended patient centered outcome measure in rheumatoid arthritis. J Rheumatol 34:1174–1177
2. Hart BL (1988) Biological basis of the behavior of sick animals. Neurosci Biobehav R 12:123–137
3. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelly KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–57
4. Norheim KB, Jonsson G, Omdal R (2011) Biological mechanisms of chronic fatigue. Rheumatology 50:1009–1018
5. Harboe E, Tjensvoll AB, Vefring HK, Goransson LG, Kvaloy JT, Omdal R (2009) Fatigue in primary Sjogren’s syndrome—A link to sickness behaviour in animals? Brain Behav Immun 23:1104–1108
6. Norheim KB, Harboe E, Goransson LG, Omdal R (2012) Interleukin-1 inhibition and fatigue in primary Sjogren’s syndrome—A double blind, randomised clinical trial. PLoS One 7:e30123
7. Flannagan RS, Cosio G, Grinstein S (2009) Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Nat Rev Microbiol 7:355–366
8. West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472:476–480
9. Gabrielli A, Avvedimento EV, Krieg T (2009) Mechanisms of disease: scleroderma. New Engl J Med 360:1989–2003
10. Brkic S, Tomic S, Maric D, Mikic AN, Turkulov V (2010) Lipid peroxidation is elevated in female patients with chronic fatigue syndrome. Med Sci Monitor 16:628–632
11. Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJF (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Bio Med 39:584–589
12. Avalos I, Chung CP, Oeser A, Milne GL, Morrow JD, Gebretsadik T et al (2007) Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms. Lupus 16:195–200
13. Chung CP, Titova D, Oeser A, Randels M, Avalos I, Milne GL et al (2009) Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol 28:435–438
14. Segal BM, Thomas W, Zhu X, Diebes A, McElvain G, Baechler E et al (2012) Oxidative stress and fatigue in systemic lupus erythematosus. Lupus 21:984–992
15. Giera M, Ioan-Facsinay A, Toes R, Gao F, Dalli J, Deelder AM et al (2012) Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. Biochim Biophys Acta 1821:1415–1424
16. Fuchs B, Schiller E, Wagner U, Hantzschel H, Arnold K (2005) The phosphatidylcholine/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: investigations by P-31 NMR and MALDI-TOF MS. Clin Biochem 38:925–933
17. Kim S, Hwang J, Xuan J, Jung YH, Cha HS, Kim KH (2014) Global metabolite profiling of synovial fluid for the specific diagnosis of rheumatoid arthritis from other inflammatory arthritis. PLoS One 9:e97501
18. Young SP, Kapoor SR, Viant MR, Byrne JJ, Filer A, Buckley CD et al (2013) The impact of inflammation on metabolomic profiles in patients with arthritis. Arthritis Rheum 65:2015–2023
19. Madsen RK, Lundstedt T, Gabrielsson J, Sennbro CJ, Alenius GM, Moritz T et al (2011) Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Arthritis Res Ther 13:R19
20. Wang Z, Chen Z, Yang S, Wang Y, Yu L, Zhang B et al (2012) (1)H NMR-based metabolomic analysis for identifying serum biomarkers to evaluate methotrexate treatment in patients with early rheumatoid arthritis. Exp Ther Med 4:165–171
21. Kapoor SR, Filer A, Fitzpatrick MA, Fisher AB, Taylor PC, Buckley CD et al (2013) Metabolic profiling predicts response to anti-tumor necrosis factor alpha therapy in patients with rheumatoid arthritis. Arthritis Rheum 65:1448–1456
22. Madsen R, Rantapaa-Dahlqvist S, Lundstedt T, Moritz T, Trygg J (2012) Metabolic responses to change in disease activity during tumor necrosis factor inhibition in patients with rheumatoid arthritis. J Proteome Res 11:3796–3804
23. 1H NMR spectroscopy-based interventional metabolic phenotyping: a cohort study of rheumatoid arthritis patients. J Proteome Res 9:4545–4553
24. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd et al (2010) 2010 rheumatoid arthritis classification criteria: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 69:1580–1588
25. Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J et al (2009) Validation of the 28-joint Disease Activity Score (DAS28) and European league against rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 68:954–960
26. Balsa A, Carmona L, Gonzalez-Alvaro I, Belmonte MA, Tena X, Sanmarti R et al (2004) Value of Disease Activity Score 28 (DAS28) and DAS28-3 compared to American college of rheumatology-defined remission in rheumatoid arthritis. J Rheumatol 31:40–46
27. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123
28. Wolfe F, Hawley DJ, Wilson K (1996) The prevalence and meaning of fatigue in rheumatic disease. J Rheumatol 23:1407–1417
29. Jiye A, Trygg J, Gullberg J, Johannson AI, Johnsson P, Antti H et al (2005) Extraction and GC/MS analysis of the human blood plasma metabolome. Anal Chem 77:8086–8094
30. Trygg J, Wold S (2002) Orthogonal projections to latent structures (O-PLS). J Chemometr 16:119–128
31. Wiklund S, Johansson E, Sjostrom L, Mellerowicz EJ, Edlund U, Schockor JP et al (2008) Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 80:115–122
32. Martens H, Naes T (1989) Multivariate calibration. Wiley, Chichester
33. Efron B, Gong G (1983) A leisurely look at the bootstrap, the jack-knife, and cross-validation. Am Stat 37:36–48
34. Xia JG, Mandal R, Sinelnikov IV, Broadhurst D, Wishart DS (2012) MetaboAnalyst 2.0—A comprehensive server for metabolomic data analysis. Nucleic Acids Res 40(W1):W127–W133
35. Villamena FA (2013) Molecular basis of oxidative stress: chemistry, mechanisms, and disease pathogenesis. Wiley, Hoboken
36. Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML et al (2011) Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc T 39:1226–1232
37. Jones MG, Cooper E, Amjad S, Goodwin CS, Barron JL, Chalmers RA (2005) Urinary and plasma organic acids and amino acids in chronic fatigue syndrome. Clin Chim Acta 361:150–158
38. Kurup RK, Kurup PA (2003) Isoprenoid pathway dysfunction in chronic fatigue syndrome. Acta Neuropsychiatr 15:266–273
39. Niki E (2014) Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radical Bio Med 66:3–12
40. Vasanthi P, Nalini G, Rajasekhar G (2009) Status of oxidative stress in rheumatoid arthritis. Int J Rheum Dis 12:29–33
41. Armstrong CW, McGregor NR, Sheedy JR, Buttfield I, Butt HL, Gooley PR (2012) NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome. Clin Chim Acta 413:1525–1531
42. Balboa MA, Balsinde J (2006) Oxidative stress and arachidonic acid mobilization. Biochim Biophys Acta 1761:385–391
43. Keyser RE, Rus V, Cade WT, Kalappa N, Flores RH, Handwerger BS (2003) Evidence for aerobic insufficiency in women with systemic lupus erythematosus. Arthritis Rheum 49:16–22
44. Grimstad T, Norheim KB, Isaksen K, Leitao K, Hetta AK, Carlsen A et al (2015) Fatigue in newly diagnosed inflammatory bowel disease. J Crohns Colitis 9:725–730