The Danish urban-rural gradient of allergic sensitization and disease in adults

Clinical and Experimental Allergy

Volumn 46, Issue 1, 2016, Pages 103-111

  Elholm, G ^a   Linneberg, A ^b,c,d   Husemoen, L L N ^b   Omland, O ^e   Gronager P M ^f   Sigsgaard, T ^a   Schlunssen V ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Unit for Psychotherapy Education and Research   (Denmark)

^c GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e AALBORG UNIVERSITY HOSPITAL   (Denmark)

^f ALK ABELLÓ   (Denmark)

Author keywords

Adults; Allergy; Environmental exposure; Homogenous population; Industrialized country; Urbanization

Indexed keywords

ALLERGEN; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E;

ADULT; ALLERGENICITY; ALLERGIC ASTHMA; ALLERGIC RHINITIS; ARTICLE; BIRCH; CAT; CHILDHOOD; DENMARK; GRASS; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MALE; POPULATION EXPOSURE; PREVALENCE; PRICK TEST; PRIORITY JOURNAL; RISK ASSESSMENT; RURAL AREA; SENSITIZATION; URBAN AREA; URBANIZATION; ADOLESCENT; AGED; ANIMAL; BLOOD; FEMALE; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOLOGY; MIDDLE AGED; QUESTIONNAIRE; RISK FACTOR; RURAL POPULATION; SKIN TEST; URBAN POPULATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLERGENS; ANIMALS; DENMARK; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; RISK ASSESSMENT; RISK FACTORS; RURAL POPULATION; SKIN TESTS; SURVEYS AND QUESTIONNAIRES; URBAN POPULATION; YOUNG ADULT;

EID: 84955313953     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12583     Document Type: Article

References (28)

1. Beasley R. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998; 351:1225-32.
2. Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy 2005; 60:1357-60.
3. Van Niekerk CH, Weinberg EG, Shore SC, Heese HV, Van SJ. Prevalence of asthma: a comparative study of urban and rural Xhosa children. Clin Allergy 1979; 9(4):319-4.
4. Yemaneberhan H, Bekele Z, Venn A, Lewis S, Parry E, Britton J. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. Lancet 1997; 350:85-90.
5. Wong GW, Ko FW, Hui DS et al. Factors associated with difference in prevalence of asthma in children from three cities in China: multicentre epidemiological survey. BMJ 2004; 329:486.
6. Kim YK, Chang YS, Lee MH et al. Role of environmental exposure to spider mites in the sensitization and the clinical manifestation of asthma and rhinitis in children and adolescents living in rural and urban areas. Clin Exp Allergy 2002; 32:1305-9.
7. Barnes M, Cullinan P, Athanasaki P et al. Crete: does farming explain urban and rural differences in atopy? Clin Exp Allergy 2001; 31:1822-8.
8. Bibi H, Shoseyov D, Feigenbaum D et al. Comparison of positive allergy skin tests among asthmatic children from rural and urban areas living within small geographic area. Ann Allergy Asthma Immunol 2002; 88:416-20.
9. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299:1259-60.
10. Braun-Fahrlander C, Gassner M, Grize L et al. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy 1999; 29:28-34.
11. Omland O, Sigsgaard T, Hjort C, Pedersen OF, Miller MR. Lung status in young Danish rurals: the effect of farming exposure on asthma-like symptoms and lung function. Eur Respir J 1999; 13:31-7.
12. Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000; 30:194-200.
13. Von Ehrenstein OS, Von Mutius E, Illi S, Baumann L, Bohm O, von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000; 30:187-93.
14. Hersoug LG, Husemoen LL, Thomsen SF, Sigsgaard T, Thuesen BH, Linneberg A. Association of indoor air pollution with rhinitis symptoms, atopy and nitric oxide levels in exhaled air. Int Arch Allergy Immunol 2010; 153:403-12.
15. Elholm G, Omland O, Schlunssen V, Hjort C, Basinas I, Sigsgaard T. The cohort of young Danish farmers - A longitudinal study of the health effects of farming exposure. Clin Epidemiol 2010; 2:45-50.
16. Thyssen JP, Johansen JD, Linneberg A et al. The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. Br J Dermatol 2010; 162:1278-85.
17. Petersen AB, Gudmann P, Milvang-Gronager P et al. Performance evaluation of a specific IgE assay developed for the ADVIA centaur immunoassay system. Clin Biochem 2004; 37:882-92.
18. Kauffmann F, Oryszczyn MP, Maccario J. The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyper-responsiveness and atopy. Clin Exp Allergy 2002; 32:379-86.
19. Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Childhood farm environment and asthma and sensitization in young adulthood. Allergy 2002; 57:1130-5.
20. Portengen L, Sigsgaard T, Omland O, Hjort C, Heederik D, Doekes G. Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm. Clin Exp Allergy 2002; 32:247-53.
21. Koskela HO, Happonen KK, Remes ST, Pekkanen J. Effect of farming environment on sensitisation to allergens continues after childhood. Occup Environ Med 2005; 62:607-11.
22. Douwes J, Travier N, Huang K et al. Lifelong farm exposure may strongly reduce the risk of asthma in adults. Allergy 2007; 62:1158-65.
23. Linneberg A, Nielsen NH, Madsen F, Frolund L, Dirksen A, Jorgensen T. Smoking and the development of allergic sensitization to aeroallergens in adults: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2001; 56:328-32.
24. Hancox RJ, Welch D, Poulton R et al. Cigarette smoking and allergic sensitization: a 32-year population-based cohort study. J Allergy Clin Immunol 2008; 121:38-42.
25. Goel N, Singh BP, Arora N, Kumar R. Effect of smoking on atopic predisposition and sensitisation to allergens. Indian J Chest Dis Allied Sci 2008; 50:329-33.
26. Thyssen JP, Johansen JD, Menne T, Nielsen NH, Linneberg A. Effect of tobacco smoking and alcohol consumption on the prevalence of nickel sensitization and contact sensitiza-tion. Acta Derm Venereol 2010; 90:27-33.
27. Adisesh A, Gruszka L, Robinson E, Evans G. Smoking status and immunoglobulin E seropositivity to workplace allergens. Occup Med (Lond) 2011; 61:62-4.
28. Eduard W, Douwes J, Omenaas E, Heederik D. Do farming exposures cause or prevent asthma? Results from a study of adult Norwegian farmers. Thorax 2004; 59:381-6.