Quantifying the role of circulating unconjugated estradiol in mediating the body mass index-breast cancer association

Cancer Epidemiology Biomarkers and Prevention

Volumn 25, Issue 1, 2016, Pages 105-113

  Schairer, Catherine ^a   Fuhrman, Barbara J ^b   Boyd Morin, Jennifer ^c   Genkinger, Jeanine M ^d,e   Gail, Mitchell H ^a   Hoover, Robert N ^a   Ziegler, Regina G ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c INFORMATION MANAGEMENT SERVICES INC   (United States)

^d Department of Medicine   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; TUMOR MARKER;

ADULT; AGED; BLOOD; BODY MASS; BREAST NEOPLASMS; CANCER STAGING; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; COMPLICATION; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; OBESITY; PATHOLOGY; POSTMENOPAUSE; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TUMOR INVASION; YOUNG ADULT;

ADULT; AGED; BIOMARKERS, TUMOR; BODY MASS INDEX; BREAST NEOPLASMS; CASE-CONTROL STUDIES; ESTRADIOL; ESTROGENS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; OBESITY; POSTMENOPAUSE; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 84955296676     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-15-0687     Document Type: Article

References (31)

1. Fuhrman BJ, Schairer C, Gail MH, Boyd-Morin J, Xu X, Sue LY, et al. Estrogen metabolism and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2012;104:326-39.
2. Lahmann PH, Schulz M, Hoffmann K, Boeing H, Tjønneland A, Olsen A, et al. Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC). Br J Cancer 2005;93:582-9.
3. Morimoto LM, White E, Chen Z, Chlebowski RT, Hays J, Kuller L, et al. Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States). Cancer Causes Control 2002;13:741-51.
4. Slattery ML, Sweeney C, Edwards S, Herrick J, Baumgartner K, Wolff R, et al. Body size, weight change, fat distribution and breast cancer risk in Hispanic and non-Hispanic white women. Breast Cancer Res Treat 2007;102:85-101.
5. Suzuki R, Rylander-Rudqvist T, Ye W, Saji S, Wolk A. Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: a prospective cohort study. Int J Cancer 2006;119:1683-9.
6. Feigelson HS, Jonas CR, Teras LR, Thun MJ, Calle EE. Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev 2004;13:220-4.
7. Suzuki R, Orsini N, Saji S, Key TJ, Wolk A. Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status - A meta-analysis. Int J Cancer 2009;124:698-712.
8. Cleary MP, Grossmann ME. Minireview: obesity and breast cancer: the estrogen connection. Endocrinology 2009;150:2537-42.
9. Endogenous Hormones and Breast Cancer Collaborative Group. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003;95:1218-26.
10. Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, et al. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 2009;101:48-60.
11. Rinaldi S, Key TJ, Peeters PHM, Lahmann PH, Lukanova A, Dossus L, et al. Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort. Int J Cancer 2006;118:2832-9.
12. Hvidtfeldt UA, Gunter MJ, Lange T, Chlebowski RT, Lane D, Farhat GN, et al. Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer. Cancer Epidemiol Biomarkers Prev 2012;21:1203-12.
13. Varmus H, Harlow E. Provocative questions in cancer research. Nature 2012;481:436-7.
14. Clincial guideline on the identification, evaluation and treatment of overweight and obesity in adults - The Evidence Report. National Institutes of Health Obes Res 1998;6 Suppl 2:51S-209S.
15. Physical status: The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee 1995 Geneva, Switzerland: World Health Organization.
16. Lange T, Hansen JV. Direct and indirect effects in a survival context. Epidemiology 2011;22:575-81.
17. VanderWeele TJ. Causal mediation analysis with survival data. Epidemiology 2011;22:582-5.
18. Engstrom JL, Paterson PA, Doherty A, Trabulsi M, Speer KL. Accuracy of self-reported height and weight in women: an integrative review of literature. J Midwifery Women Health 2003;48:338-45.
19. Jain RB. Regression models to predict corrected weight, height and obesity prevalence from self-reported data: data from the BRFSS 1992-2007. Int J Obesity 2010;34:1655-64.
20. Kaaks R, Rinaldi S, Key TJ, Berrino F, Peeters PHM, Biessy C, et al. Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 2005;12:1071-82.
21. Bezemer ID, Rinaldi S, Dossus L, van Gils CH, Peeters PHM, van Noord PA, et al. C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control 2005;16:561-72.
22. McTiernan A, Wu L, Chen C, Chlebowski R, Mossavar-Rahmani Y, Modugno F, et al. Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity 2006;14:1662-77.
23. Brown KA, Simpson ER. Obesity and breast cancer: progress to understanding the relationship. Cancer Res 2010;70:4-7.
24. Pichard C, Plu-Bureau G, Castro MN, Gompel A. Insulin resistance, obesity and breast cancer risk. Maturitas 2008;60:19-30.
25. Schairer C, McCarthy CA, Isaacs C, Sue LY, Pollak MN, Berg CD, et al. Circulating insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 levels and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cacner screening trial (PLCO) cohort. Horm Cancer 2010;1:100-11.
26. Ziegler RG, Faupel-Badger JM, Sue LY, Fuhrman BJ, Falk RT, Boyd-Morin J, et al. A new approach to measuring estrogen exposure and metabolism in epidemiologic studies. J Steroid Biochem Mol Biol 2010;121:538-45.
27. Endogenous Hormones and Breast Cancer Collaborative Group. Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: reanalysis of eighteen prospective studies. Steroids 2015;99:49-55.
28. Stanczyk FZ, Jurow J, Hsing AW. Limitations of direct immunoassays for measuring circulating estradiol levels in postmenopausal women and men in epidemiologic studies. Cancer Epidemiol Biomarkers Prev 2010;19:903-6.
29. Lee SJ, Ettinger B, Stanczyk FZ, Vittinghoff E, Hanes V, Cauley JA, et al. Comparison of methods to measure low serum estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2006;91:3791-7.
30. Rosner W, Hankinson SE, Sluss PM, Vesper HW, Wierman ME. Challenges to the measurement of estradiol: an endocrine society position statement. J Clin Endocrinol Metab 2013;98:1376-87.
31. Jones ME, Schoemaker MJ, Rae M, Folkerd EJ, Dowsett M, Ashworth A, et al. Reproducibility of estradiol and testosterone levels in postmenopausal women over 5 years: results from the breakthrough generations study. Am J Epidemiol 2014;179:1128-33.