Patient survey to identify reasons for non-adherence and elicitation of quality of life concepts associated with immunosuppressant therapy in kidney transplant recipients

Patient Preference and Adherence

Volumn 10, Issue , 2016, Pages 27-36

  Muduma, Gorden ^a   Shupo, Francis C ^b   Dam, Sophie ^b   Hawken, Natalia A ^b   Aballéa, Samuel ^b   Odeyemi, Isaac ^a   Toumi, Mondher ^c  

^a ASTELLAS PHARMA EUROPE LTD   (United Kingdom)

^b CREATIV CEUTICAL   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Adherence; Conceptual framework; Immunosuppressant; PRO; QoL; Renal transplantation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ADULT; ADVERSE DRUG REACTION; AGED; AGGRESSION; ANXIETY; ARTHRALGIA; ARTHRITIS; ARTICLE; BEHAVIOR DISORDER; BLISTER; CLINICAL ARTICLE; COGNITIVE DEFECT; CONCEPTUAL FRAMEWORK; DIARRHEA; DROWSINESS; DRY SKIN; EVENING DOSAGE; EXHAUSTION; FATIGUE; FEMALE; GASTROINTESTINAL DISEASE; HAIR LOSS; HEADACHE; HUMAN; HYPERPARATHYROIDISM; HYPERTHYROIDISM; IMMUNOSUPPRESSIVE TREATMENT; INSOMNIA; KIDNEY TRANSPLANTATION; LIFESTYLE; MALE; MEDICATION COMPLIANCE; MENTAL INSTABILITY; MIDDLE AGED; MOON FACE; MORNING DOSAGE; OSTEOPOROSIS; PATIENT PREFERENCE; PERSONALITY DISORDER; PHOTOSENSITIVITY; QUALITATIVE RESEARCH; QUALITY OF LIFE; RASH; RECALL; RESTLESS LEGS SYNDROME; SEMI STRUCTURED INTERVIEW; SIDE EFFECT; SKIN CANCER; SKIN DISEASE; SKIN PRURITUS; SLEEP; SOCIAL DISABILITY; SWEAT; SWEATING; TREMOR; URTICARIA; VERRUCA VULGARIS; WORK DISABILITY;

EID: 84955267298     PISSN: None     EISSN: 1177889X     Source Type: Journal    
DOI: 10.2147/PPA.S96086     Document Type: Article

References (38)

1. Port FK, Wolfe RA, Mauger EA, Berling DP, Jiang K. Comparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients. JAMA. 1993; 270: 1339-1343.
2. Tanriover B, Stone PW, Mohan S, Cohen DJ, Gaston RS. Future of medi­care immunosuppressive drug coverage for kidney transplant recipients in the United States. Clin J Am Soc Nephrol. 2013; 8: 1258-1266.
3. Maclean JR, Pfister M, Zhou Z, Roy A, Tuomari VA, Heifets M. Quantifying the impact of nonadherence patterns on exposure to oral immunosuppressants. Ther Clin Risk Manag. 2011; 7: 149-156.
4. Constantiner M, Cukor D. Barriers to immunosuppressive medication adherence in high-risk adult renal transplant recipients. Dial Transpl. 2011; 40: 60-66.
5. Denhaerynck K, Dobbels F, Cleemput I, et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: a literature review. Transpl Int. 2005; 18: 1121-1133.
6. Nevin TE, Thomas W. Quantitative patterns of Azathioprine adherence after renal transplantation. Transplantation. 2009; 711-718.
7. Kuypers DR, Peeters PC, Sennesael JJ, et al. Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring. Transplantation. 2013; 95: 333-340.
8. Butler JA, Roderick P, Mullee M, Mason JC, Peveler RC. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: a systematic review. Transplantation. 2004; 77: 769-776.
9. Sellares J, de Freitas DG, Mengel M, et al. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant. 2012; 12: 388-399.
10. Vlaminck H, Maes B, Evers G, et al. Prospective study on late conse­quences of subclinical non-compliance with immunosuppressive ther­apy in renal transplant patients. Am J Transplant. 2004; 4: 1509-1513.
11. Germin-Petrovic D, Mesaros-Devcic I, Lesac A, et al. Health-related quality of life in the patients on maintenance hemodialysis: the analysis of demographic and clinical factors. Coll Antropol. 2011; 35: 687-693.
12. Franke GH, Trampenau C, Reimer J. Switching from cyclosporine to tacrolimus leads to improved disease-specific quality of life in patients after kidney transplantation. Transplant Proc. 2006; 38: 1293-1294.
13. Prasad GV, Nash MM, Keough-Ryan T, Shapiro RJ. A quality of life comparison in cyclosporine-and tacrolimus-treated renal transplant recipients across Canada. J Nephrol. 2010; 23: 274-281.
14. Calia R, Lai C, Aceto P, et al. Effects of switching from twice-daily to once-daily tacrolimus formulation on quality of life, anxiety, and trans­plant benefit perception after kidney transplantation. Transplant Proc. 2011; 43: 1020-1023.
15. Gorevski E, Succop P, Sachdeva J, et al. Is there an association between immunosuppressant therapy medication adherence and depression, quality of life, and personality traits in the kidney and liver transplant population? Patient Prefer Adherence. 2013; 7: 301-307.
16. Orr A, Orr D, Willis S, Holmes M, Britton P. Patient perceptions of factors influencing adherence to medication following kidney transplant. Psychol Health Med. 2007; 12: 509-517.
17. Griva K, Davenport A, Harrison M, Newman SP. Non-adherence to immunosuppressive medications in kidney transplantation: intent vs. forgetfulness and clinical markers of medication intake. Ann Behav Med. 2012; 44: 85-93.
18. Gordon EJ, Gallant M, Sehgal AR, Conti D, Siminoff LA. Medication-taking among adult renal transplant recipients: barriers and strategies. Transpl Int. 2009; 22: 534-545.
19. Kitzinger J. Qualitative research. Introducing focus groups. BMJ. 1995; 311: 299-302.
20. Moore M, Zelikovsky N, Mindell JA. A pilot study of sleep and medica­tion adherence in adolescent kidney transplant recipients. Poster presented at: Sleep Conference: 24th Annual Meeting of the Associated Profes­sional Sleep Societies, LLC, SLEEP 2010; June 5-9, 2010; San Antonio, TX, USA.
21. Normen M, Surendran V, Ganesan P, Rajendranath R, Sagar TG. Patients' perspectives on adherence to treatment in chronic myeloid leukemia. In: Psycho-Oncology Conference: 15th World Congress of Psycho-Oncology of the International Psycho-Oncology Society, IPOS; November 4-8, 2013, Rotterdam, the Netherlands.
22. Kugler C, Gottlieb J, Dierich M, et al. Significance of patient self-monitoring for long-term outcomes after lung transplantation. Clin Transplant. 2010; 24: 709-716.
23. Evans RW, Applegate WH, Briscoe DM, et al. Cost-related immunosup­pressive medication nonadherence among kidney transplant recipients. Clin J Am Soc Nephrol. 2010; 5: 2323-2328.
24. Ruth ND, Legarda M, Smith M, et al. Long term outcome after liver transplant-a 15 year retrospective review. In: Hepatology Conference: 64th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2013; November 1-5, 2013; Washington, DC, USA.
25. Guimaraes Marcelino CA, da Cruz DM. The effectiveness of interven­tions to manage treatment adherence in adult heart transplant patients: a systematic review protocol. JBI Database of System Rev Implement Rep. 2013; 11: 2013.
26. Weng FL, Israni AK, Joffe MM, et al. Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation. J Am Soc Nephrol. 2005; 16: 1839-1848.
27. De Bleser L, Matteson M, Dobbels F, Russell C, De Geest S. Inter­ventions to improve medication-adherence after transplantation: a systematic review. Transpl Int. 2009; 22: 780-797.
28. Russell CL, Kilburn E, Conn VS, Libbus MK, Ashbaugh C. Medication-taking beliefs of adult renal transplant recipients. Clin Nurse Spec. 2003; 17: 200-208.
29. Guirado L, Cantarell C, Franco A, et al. Efficacy and safety of conver­sion from twice-daily to once-daily tacrolimus in a large cohort of stable kidney transplant recipients. Am J Transplant. 2011; 11: 1965-1971.
30. Morales JM, Varo E, Lazaro P. Immunosuppressant treatment adherence, barriers to adherence and quality of life in renal and liver transplant recipients in Spain. Clin Transplant. 2012; 26: 369-376.
31. Ichimaru N, Kakuta Y, Abe T, et al. Treatment adherence in renal transplant recipients: a questionnaire survey on immunosuppressants. Transplant Proc. 2008; 40: 1362-1365.
32. Sabbatini M, Garofalo G, Borrelli S, et al. Efficacy of a reduced pill burden on therapeutic adherence to calcineurin inhibitors in renal transplant recipients: an observational study. Patient Prefer Adherence. 2014; 8: 73-81.
33. Lehane E, McCarthy G. Intentional and unintentional medication non-adherence: a comprehensive framework for clinical research and practice? A discussion paper. Int J Nurs Stud. 2007; 44: 1468-1477.
34. Franke GH, Reimer J, Philipp T, Heemann U. Aspects of quality of life through end-stage renal disease. Qual Life Res. 2003; 12: 103-115.
35. Alloway R, Steinberg S, Khalil K, et al. Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen. Transplant Proc. 2005; 37: 867-870.
36. Gajree S, Clancy M. The transition of young adult renal transplant recipi­ents into adult care: a west of Scotland perspective. In: Transplant Inter­national Conference: 16th Congress of the European Society for Organ Transplantation, ESOT; September 8-11, 2013; Vienna, Austria.
37. Lim KB, Hartono JL, Dan YY, et al. Adherence to immunosuppressive therapy in adult and adolescent liver transplant recipients in a multi-ethnic Asian Centre: a questionnaire survey. In: Hepatology Conference: 65th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2014; November 8-10, 2014; Boston, MA, USA.
38. Annunziato RA, Arrato N, Rubes M, Arnon R. The importance of mental health monitoring during transfer to adult care settings as exam­ined among paediatric transplant recipients. J Paediatr Child Health. 2015; 51: 220-222.