Porcine deltacoronavirus induces apoptosis in swine testicular and LLC porcine kidney cell lines in vitro but not in infected intestinal enterocytes in vivo

Veterinary Microbiology

Volumn 182, Issue , 2016, Pages 57-63

  Jung, Kwonil ^a   Hu, Hui ^a   Saif, Linda J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell death; Coronavirus; Necrosis; Pig; Porcine deltacoronavirus; Virus

Indexed keywords

LIPOCORTIN 5; VIRUS ANTIGEN; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CECUM; CELL VACUOLE; CHROMATIN; COMPARATIVE STUDY; CONTROLLED STUDY; CORONAVIRIDAE; CORONAVIRUS INFECTION; DIARRHEA; DUODENUM; EPITHELIUM CELL; EXPERIMENTAL PIG; GNOTOBIOTICS; HISTOPATHOLOGY; ILEAL TISSUE; ILEUM; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; INTESTINE VILLUS ATROPHY; JEJUNUM; KIDNEY CELL; MALE; NONHUMAN; PORCINE DELTACORONAVIRUS; TESTIS CELL; TUNEL ASSAY; VOMITING; ANIMAL; CELL LINE; CYTOLOGY; ENTEROPATHY; GERMFREE ANIMAL; INTESTINE; KIDNEY; PATHOLOGY; PHYSIOLOGY; PIG; STAINING; SWINE DISEASE; TESTIS; VETERINARY; VIROLOGY;

ANIMALS; APOPTOSIS; CELL LINE; CORONAVIRUS; ENTEROCYTES; GERM-FREE LIFE; IN SITU NICK-END LABELING; INTESTINAL DISEASES; INTESTINES; KIDNEY; MALE; STAINING AND LABELING; SWINE; SWINE DISEASES; TESTIS;

EID: 84955147798     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2015.10.022     Document Type: Article

References (17)

1. Chen Q., Gauger P., Stafne M., Thomas J., Arruda P., Burrough E., Madson D., Brodie J., Magstadt D., Derscheid R., Welch M., Zhang J. Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets. Virology 2015, 482:51-59.
2. Eleouet J.F., Chilmonczyk S., Besnardeau L., Laude H. Transmissible gastroenteritis coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway. J. Virol. 1998, 72:4918-4924.
3. Finkbeiner S.R., Zeng X.L., Utama B., Atmar R.L., Shroyer N.F., Estes M.K. Stem cell-derived human intestinal organoids as an infection model for rotaviruses. mBio 2012, 3:159-100112.
4. Ganges L., Nunez J.I., Sobrino F., Borrego B., Fernandez-Borges N., Frias-Lepoureau M.T., Rodriguez F. Recent advances in the development of recombinant vaccines against classical swine fever virus: cellular responses also play a role in protection. Vet. J. 2008, 177:169-177.
5. Hu H., Jung K., Vlasova A.N., Chepngeno J., Lu Z., Wang Q., Saif L.J. Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States. J. Clin. Microbiol. 2015, 53:1537-1548.
6. Jones T.C., Hunt R.D., King N.W. Veterinary Pathology 1997, 1-24. Lippincott Williams & Wilkins. 6th ed.
7. Jung K., Hu H., Eyerly B., Lu Z., Chepngeno J., Saif L.J. Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs. Emerg. Infect. Dis. 2015, 21:650-654.
8. Jung K., Renukaradhya G.J., Alekseev K.P., Fang Y., Tang Y., Saif L.J. Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections. J. Gen. Virol. 2009, 90:2713-2723.
9. Jung K., Saif L.J. Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis and immunoprophylaxis. Vet. J. 2015, 204:134-143.
10. Kim B., Kim O., Tai J.H., Chae C. Transmissible gastroenteritis virus induces apoptosis in swine testicular cell lines but not in intestinal enterocytes. J. Comp. Pathol. 2000, 123:64-66.
11. Kim Y., Lee C. Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor. Virology 2014, 460-461:180-193.
12. Lau S.K., Woo P.C., Yip C.C., Fan R.Y., Huang Y., Wang M., Guo R., Lam C.S., Tsang A.K., Lai K.K., Chan K.H., Che X.Y., Zheng B.J., Yuen K.Y. Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits. J. Virol. 2012, 86:5481-5496.
13. Li G., Chen Q., Harmon K.M., Yoon K.J., Schwartz K.J., Hoogland M.J., Gauger P.C., Main R.G., Zhang J. Full-length genome sequence of porcine deltacoronavirus strain USA/IA/2014/8734. Genome Announc. 2014, 2:e278-e314.
14. Marthaler D., Jiang Y., Collins J., Rossow K. Complete genome sequence of strain SDCV/USA/Illinois121/2014, a porcine deltacoronavirus from the United States. Genome Announc. 2014, 2:e218-e314.
15. Miller L.C., Fox J.M. Apoptosis and porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 2004, 102:131-142.
16. Sanad Y.M., Jung K., Kashoma I., Zhang X., Kassem I.I., Saif Y.M., Rajashekara G. Insights into potential pathogenesis mechanisms associated with Campylobacter jejuni-induced abortion in ewes. BMC Vet. Res. 2015, 10:274.
17. Wang L., Byrum B., Zhang Y. Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014. Emerg. Infect. Dis. 2014, 20:1227-1230.