First steps toward harmonization of LC-MS/MS thyroglobulin assays

Clinical Chemistry

Volumn 62, Issue 1, 2016, Pages 297-299

  Netzel, Brian C ^a   Grant, Russell P ^b   Hoofnagle, Andrew N ^c   Rockwood, Alan L ^d,e   Shuford, Christopher M ^b   Grebe, Stefan K G ^a,f  

^a Department of Laboratory Medicine and Pathology ^*  (United States)

^b LABORATORY CORPORATION OF AMERICA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e ARUP LABORATORIES   (United States)

^f MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROGLOBULIN;

HUMAN; IMMUNOASSAY; IMMUNOASSAY ANALYZER; LETTER; LIQUID CHROMATOGRAPHY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; TANDEM MASS SPECTROMETRY; THYROGLOBULIN BLOOD LEVEL; BLOOD; STANDARDS;

CHROMATOGRAPHY, LIQUID; HUMANS; TANDEM MASS SPECTROMETRY; THYROGLOBULIN;

EID: 84954472771     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2015.245266     Document Type: Letter

References (5)

1. Spencer CA. Challenges of serum thyroglobulin (Tg) measurement in the presence of Tg autoantibodies. J Clin Endocrinol Metab 2004;89:3702-4.
2. Netzel BC, Grebe SKG, Carranza Leon G, Castro AR, Clark PM, Hoofnagle AN, et al. Thyroglobulin (Tg) testing revisited: Tg assays, TgAb assays, and correlation of results with clinical outcomes. J Clin Endocrinol Metab 2015;100:E1074-83.
3. Hoofnagle AN, Becker JO, Wener MH, Heineck JW. Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clin Chem 2008;54:1796-804.
4. Kushnir MM, Rockwood AL, Roberts WL, Abraham D, Hoofnagle AN, Meikle AW. Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies. Clin Chem 2013;59:982-90.
5. Spencer C, Petrovic I, Fatemi S, LoPresti J. Serum thyroglobulin (Tg) monitoring of patients with differentiated thyroid cancer with sensitive (second-generation) immunometric assays can be disrupted by falsenegative and false-positive serum thyroglobulin autoantibody misclassifications. J Clin Endocrinol Metab 2014;99:4589-99.