Predictors of blood pressure response: Obesity is associated with a less pronounced treatment response after renal denervation

Catheterization and Cardiovascular Interventions

Volumn 87, Issue 1, 2016, Pages E30-E38

  Id, Dani ^a   Bertog, Stefan C ^a,b   Ziegler, Ann Kathrin ^a   Hornung, Marius ^a   Hofmann, Ilona ^a   Vaskelyte, Laura ^a   Matic, Predrag ^a   Gafoor, Sameer ^a   Sievert, Horst ^a  

^a CARDIOVASCULAR CENTER FRANKFURT   (Germany)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

ablation; hypertension; radiofrequency

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ADULT; AGE; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CATHETER; CLINICAL EFFECTIVENESS; DIABETES MELLITUS; FEMALE; GENDER; HUMAN; KIDNEY DENERVATION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; OBESITY; PATIENT SELECTION; PREDICTION; RADIOFREQUENCY ABLATION; RESISTANT HYPERTENSION; RETROSPECTIVE STUDY; SYSTOLIC BLOOD PRESSURE; TREATMENT RESPONSE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; COMPLICATION; FOLLOW UP; HYPERTENSION; INNERVATION; KIDNEY; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SYMPATHECTOMY; TIME FACTOR; TREATMENT OUTCOME;

BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; KIDNEY; MALE; MIDDLE AGED; OBESITY; RETROSPECTIVE STUDIES; SYMPATHECTOMY; TIME FACTORS; TREATMENT OUTCOME;

EID: 84954389357     PISSN: 15221946     EISSN: 1522726X     Source Type: Journal    
DOI: 10.1002/ccd.26068     Document Type: Article

References (25)

1. Grassi G,. Role of the sympathetic nervous system in human hypertension. J Hypertens 1998; 16 (12 Part 2): 1979-1987.
2. Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, and others. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 2009; 373: 1275-1281.
3. Symplicity HTNI, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M,. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 2010; 376: 1903-1909.
4. Zuern CS, Eick C, Rizas KD, Bauer S, Langer H, Gawaz M, Bauer A,. Impaired cardiac baroreflex sensitivity predicts response to renal sympathetic denervation in patients with resistant hypertension. J Am Coll Cardiol 2013; 62: 2124-2130.
5. Bertog SC, Blessing E, Vaskelyte L, Hofmann I, Id D, Sievert H,. Renal denervation: tips and tricks to perform a technically successful procedure. EuroIntervention 2013; 9: R83-R88.
6. Id D, Kaltenbach B, Bertog SC, Hornung M, Hofmann I, Vaskelyte L, Sievert H,. Does the presence of accessory renal arteries affect the efficacy of renal denervation?. JACC Cardiovasc Interv 2013; 6: 1085-1091.
7. Kaltenbach B, Franke J, Bertog SC, Steinberg DH, Hofmann I, Sievert H,. Renal sympathetic denervation as second-line therapy in mild resistant hypertension: A pilot study. Catheter Cardiovasc Interv 2013; 81: 335-339.
8. Ott C, Mahfoud F, Schmid A, Ditting T, Sobotka PA, Veelken R, Spies A, Ukena C, Laufs U, Uder M, and others. Renal denervation in moderate treatment-resistant hypertension. J Am Coll Cardiol 2013; 62: 1880-1886.
9. Krum H, Schlaich MP, Sobotka PA, Bohm M, Mahfoud F, Rocha-Singh K, Katholi R, Esler MD,. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet 2014; 383: 622-629.
10. Prochnau D, Heymel S, Gobel B, Figulla HR, Surber R,. Resistant hypertension: multivariate predictors of blood pressure response to renal denervation. Int J Cardiol 2013; 168: 3130-3132.
11. Mahfoud F, Ukena C, Schmieder RE, Cremers B, Rump LC, Vonend O, Weil J, Schmidt M, Hoppe UC, Zeller T, and others. Ambulatory blood pressure changes after renal sympathetic denervation in patients with resistant hypertension. Circulation 2013; 128: 132-140.
12. Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, and others. A controlled trial of renal denervation for resistant hypertension. N Engl J Med 2014; 370: 1393-1401.
13. Sinning D, Rombach S, Schultheiss HP, Gross M., Significance of Renal Denervation in the Therapy of Arterial Hypertension and Beyond. Experiences from Berlin. J Klin Endokrinol Stoffw 2014; 7. (Pre-Publishing Online).
14. Hall JE, Brands MW, Hildebrandt DA, Kuo J, Fitzgerald S,. Role of sympathetic nervous system and neuropeptides in obesity hypertension. Braz J Med Biol Res 2000; 33: 605-618.
15. Id D, Bertog SC, Wunderlich N, Sievert H,. Catheter-based renal sympathectomy. J Cardiovasc Surg (Torino) 2010; 51: 721-739.
16. Henegar JR, Zhang YJ, Rama RD, Hata C, Hall JE,. CRT-132 Catheter-based Renal Denervation Lowers Blood Pressure in Obese, Hypertensive Canines. JACC: Cardiovascular Interventions 2013; 6 (2-S): S43-S43
17. Kassab S, Kato T, Wilkins FC, Chen R, Hall JE, Granger JP,. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 1995; 25: 893-897.
18. Rumantir MS, Vaz M, Jennings GL, Collier G, Kaye DM, Seals DR, Wiesner GH, Brunner-La Rocca HP, Esler MD,. Neural mechanisms in human obesity-related hypertension. J Hypertens 1999; 17: 1125-1133.
19. Ferrier C, Jennings GL, Eisenhofer G, Lambert G, Cox HS, Kalff V, Kelly M, Esler MD,. Evidence for increased noradrenaline release from subcortical brain regions in essential hypertension. J Hypertens 1993; 11: 1217-1227.
20. Esler M, Lambert G, Vaz M, Thompson J, Kaye D, Kalff V, Kelly M, Turner A, Jennings G,. Central nervous system monoamine neurotransmitter turnover in primary and obesity-related human hypertension. Clin Exp Hypertens 1997; 19: 577-590.
21. Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME, Somers VK,. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation 1998; 98: 772-776.
22. Weber MA, Neutel JM, Smith DH,. Contrasting clinical properties and exercise responses in obese and lean hypertensive patients. J Am Coll Cardiol 2001; 37: 169-174.
23. Haddock RE, Hill CE,. Sympathetic overdrive in obesity involves purinergic hyperactivity in the resistance vasculature. J Physiol 2011; 589: 3289-3307.
24. Vink EE, Goldschmeding R, Vink A, Weggemans C, Bleijs RL, Blankestijn PJ., Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study. Nephrol Dial Transplant 2014.
25. Bramlage P, Pittrow D, Wittchen HU, Kirch W, Boehler S, Lehnert H, Hoefler M, Unger T, Sharma AM,. Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled. Am J Hypertens 2004; 17: 904-910.