Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension

Hypertension

Volumn 67, Issue 2, 2016, Pages 461-468

  Wu, Jing ^a   Montaniel, Kim Ramil C ^a   Saleh, Mohamed A ^a,c   Xiao, Liang ^a   Chen, Wei ^a   Owens, Gary K ^d   Humphrey, Jay D ^e   Majesky, Mark W ^f   Paik, David T ^b   Hatzopoulos, Antonis K ^b   Madhur, Meena S ^a   Harrison, David G ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MANSOURA UNIVERSITY   (Egypt)

^d UNIVERSITY OF VIRGINIA   (United States)

^e YALE UNIVERSITY   (United States)

^f SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

Adventitia; aorta; flow cytometer; hypertension; inflammation

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; STEM CELL ANTIGEN 1; SCLEROPROTEIN;

ADVENTITIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL STIFFNESS; ARTICLE; CELL INFILTRATION; CELL SELECTION; CELL TRANSFORMATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENDOTHELIAL TO MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; HYPERTENSION; IMMUNOFLUORESCENCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; AORTIC DISEASES; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; COMPLICATION; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; AORTIC DISEASES; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FIBROBLASTS; FIBROSIS; FLOW CYTOMETRY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR;

EID: 84954370789     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06123     Document Type: Article

References (24)

1. Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Levy D, Benjamin EJ. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2010;121:505-511. doi: 10.1161/CIRCULATIONAHA.109.886655.
2. Cooper LL, Rong J, Benjamin EJ, Larson MG, Levy D, Vita JA, Hamburg NM, Vasan RS, Mitchell GF. Components of hemodynamic load and cardiovascular events: the Framingham Heart Study. Circulation. 2015;131:354-61; discussion 361. doi: 10.1161/CIRCULATIONAHA.114.011357.
3. Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, Harrison DG. Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogenactivated protein kinase. Circ Res. 2014;114:616-625. doi: 10.1161/CIRCRESAHA.114.302157.
4. Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC, Pennathur S, Martinez FJ, Thannickal VJ. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med. 2009;15:1077-1081. doi: 10.1038/nm.2005.
5. Chandrakasan G, Bhatnagar RS. Stimulation of collagen synthesis in fibroblast cultures by superoxide. Cell Mol Biol. 1991;37:751-755.
6. Majesky MW, Dong XR, Hoglund V, Mahoney WM Jr, Daum G. The adventitia: a dynamic interface containing resident progenitor cells. Arterioscler Thromb Vasc Biol. 2011;31:1530-1539. doi: 10.1161/ATVBAHA.110.221549.
7. Passman JN, Dong XR, Wu SP, Maguire CT, Hogan KA, Bautch VL, Majesky MW. A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci USA. 2008;105:9349-9354. doi: 10.1073/pnas.0711382105.
8. Hu Y, Zhang Z, Torsney E, Afzal AR, Davison F, Metzler B, Xu Q. Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest. 2004;113:1258-1265. doi: 10.1172/JCI19628.
9. Psaltis PJ, Harbuzariu A, Delacroix S, Witt TA, Holroyd EW, Spoon DB, Hoffman SJ, Pan S, Kleppe LS, Mueske CS, Gulati R, Sandhu GS, Simari RD. Identification of a monocyte-predisposed hierarchy of hematopoietic progenitor cells in the adventitia of postnatal murine aorta. Circulation. 2012;125:592-603. doi: 10.1161/CIRCULATIONAHA.111.059360.
10. Sainz J, Al Haj Zen A, Caligiuri G, Demerens C, Urbain D, Lemitre M, Lafont A. Isolation of "side population" progenitor cells from healthy arteries of adult mice. Arterioscler Thromb Vasc Biol. 2006;26:281-286. doi: 10.1161/01.ATV.0000197793.83391.91.
11. Sakai N, Wada T, Yokoyama H, Lipp M, Ueha S, Matsushima K, Kaneko S. Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proc Natl Acad Sci USA. 2006;103:14098-14103. doi: 10.1073/pnas.0511200103.
12. Xia Y, Jin X, Yan J, Entman ML, Wang Y. CXCR6 plays a critical role in angiotensin II-induced renal injury and fibrosis. Arterioscler Thromb Vasc Biol. 2014;34:1422-1428. doi: 10.1161/ATVBAHA.113.303172.
13. Rosin NL, Sopel M, Falkenham A, Myers TL, Légaré JF. Myocardial migration by fibroblast progenitor cells is blood pressure dependent in a model of angII myocardial fibrosis. Hypertens Res. 2012;35:449-456. doi: 10.1038/hr.2011.217.
14. Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med. 1994;1:71-81.
15. Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, Wu L, Zlotnik A, Butcher EC. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. J Cell Biol. 1998;141:1053-1059.
16. Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol. 2005;174:4070-4080.
17. LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013;19:1047-1053. doi: 10.1038/nm.3218.
18. Fioret BA, Heimfeld JD, Paik DT, Hatzopoulos AK. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep. 2014;8:229-241. doi: 10.1016/j.celrep.2014.06.004.
19. Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alencar GF, Haskins RM, Swiatlowska P, Newman AA, Greene ES, Straub AC, Isakson B, Randolph GJ, Owens GK. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015;21:628-637. doi: 10.1038/nm.3866.
20. Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation. 2010;122:2529-2537. doi: 10.1161/CIRCULATIONAHA.109.930446.
21. Boisset JC, van Cappellen W, Andrieu-Soler C, Galjart N, Dzierzak E, Robin C. In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature. 2010;464:116-120. doi: 10.1038/nature08764.
22. Ieronimakis N, Hays AL, Janebodin K, Mahoney WM Jr, Duffield JS, Majesky MW, Reyes M. Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGF1 signaling in the mdx mouse model of Duchenne muscular dystrophy. J Mol Cell Cardiol. 2013;63:122-134. doi: 10.1016/j.yjmcc.2013.07.014.
23. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest. 2004;114:438-446. doi: 10.1172/JCI20997.
24. Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGF-signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012;2:1684-1696. doi: 10.1016/j.celrep.2012.10.021.