Early Anti-Coagulation after Ischemic Stroke due to Atrial Fibrillation is Safe and Prevents Recurrent Stroke

Canadian Journal of Neurological Sciences

Volumn 42, Issue 2, 2015, Pages 92-95

  Hahn, Christopher ^a   Hill, Michael D ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Anti coagulation; atrial fibrillation; ischemic stroke

Indexed keywords

AGED; ANTICOAGULATION; ARTICLE; ATRIAL FIBRILLATION; BRAIN ISCHEMIA; CANADA; CARDIOEMBOLIC STROKE; CEREBROVASCULAR ACCIDENT; FEMALE; FOLLOW UP; HEALTH SERVICE; HEART REINFARCTION; HEART STROKE VOLUME; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; RECURRENT DISEASE; RETROSPECTIVE STUDY; BRAIN; CEREBRAL INFARCTION; COMPLICATION; ISCHEMIC ATTACK, TRANSIENT; MIDDLE AGED; PATHOLOGY; STROKE; TREATMENT OUTCOME; VERY ELDERLY;

ANTICOAGULANT AGENT;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; ATRIAL FIBRILLATION; BRAIN; BRAIN ISCHEMIA; CEREBRAL INFARCTION; FEMALE; HUMANS; ISCHEMIC ATTACK, TRANSIENT; MALE; MIDDLE AGED; RECURRENCE; RETROSPECTIVE STUDIES; STROKE; TREATMENT OUTCOME;

EID: 84954356976     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/cjn.2015.7     Document Type: Article

References (16)

1. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22:983-8.
2. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857-67.
3. Connolly SJ, Ezekowitz MD, Yusaf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139-51.
4. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet. 1997;349:1569-81.
5. Berge E, Abdelnoor M, Nakstad PH, et al. Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. HAEST Study Group. Heparin in Acute Embolic Stroke Trial. Lancet. 2000;355:1205-10.
6. Saxena R, Lewis S, Berge E, et al. Risk of early death and recurrent stroke and effect of heparin in 3169 patients with acute ischemic stroke and atrial fibrillation in the International Stroke Trial. Stroke. 2001;32:2333-7.
7. Dahl T, Friis P, Abildgaard U. Dalteparin in Acute Ischemic Cerebrovascular Disease: A Safety Study. Cerebrovasc Dis. 1997;7: 28-33.
8. Kay R, Wong KS, Woo J. Pilot study of low-molecular-weight heparin in the treatment of acute ischemic stroke. Stroke. 1994;25:684-5.
9. Ganetsky M, Babu KM, Salhanick SD, et al. Dabigatran: review of pharmacology and management of bleeding complications of this novel oral anticoagulant. J Med Toxicol. 2011;7:281-7.
10. Johnston SC, Gress DR, Browner WS, et al. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000; 284:2901-6.
11. Pedraza S, Puig J, Blasco G, et al. Reliability of the ABC/2 method in determining acute infarct volume. J Neuroimaging. 2012;22:155-9.
12. Atrial Fibrillation Investigators. Echocardiographic predictors of stroke in patients with atrial fibrillation: a prospective study of 1066 patients from 3 clinical trials. Arch InternMed. 1998;158:1316-20.
13. Zabalgoitia M, Halperin JL, Pearce LA, et al. Transesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. Stroke Prevention in Atrial Fibrillation III Investigators. J Am Coll Cardiol. 1998;31:1622-6.
14. Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial. The Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. JAMA. 1998;279:1265-72.
15. Chamorro A, Vila N, Ascasco C, Blanc R. Heparin in acute stroke with atrial fibrillation: clinical relevance of very early treatment. Arch Neurol. 1999;56:1098-102.
16. Paciaroni M, Agnelli G, Micheli S, Caso V, et al. Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a metaanalysis of randomized controlled trials. Stroke. 2007;38:423-30.