Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish)

Environmental Toxicology and Chemistry

Volumn 35, Issue 4, 2016, Pages 996-1006

  Watanabe, Haruna ^a   Tamura, Ikumi ^a,b   Abe, Ryoko ^a   Takanobu, Hitomi ^a   Nakamura, Ataru ^a   Suzuki, Toshinari ^c   Hirose, Akihiko ^d   Nishimura, Tetsuji ^e   Tatarazako, Norihisa ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF PUBLIC HEALTH   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e TEIKYO HEISEI UNIVERSITY   (Japan)

Author keywords

Concentration addition; Independent action; Mixture toxicity; Pharmaceutical; Short term chronic toxicity test

Indexed keywords

AQUATIC ORGANISMS; DRUG PRODUCTS; FISH; FORECASTING; GALLIUM ALLOYS; MIXTURES;

ACTIVE PHARMACEUTICAL INGREDIENTS; CHRONIC TOXICITY; CONCENTRATION ADDITION; ENVIRONMENTAL CONCENTRATION; INDEPENDENT ACTION; MIXTURE TOXICITY; NO-OBSERVED-EFFECT-CONCENTRATIONS; PSEUDOKIRCHNERIELLA SUBCAPITATA;

TOXICITY;

BEZAFIBRATE; CLARITHROMYCIN; CROTAMITON; DIPHENHYDRAMINE; EPINASTINE; ETODOLAC; KETOPROFEN; PARACETAMOL; PHENYTOIN; SULPIRIDE; WATER POLLUTANT;

AQUATIC ORGANISM; CONCENTRATION (COMPOSITION); CYPRINID; DRUG; EMBRYO; FRESHWATER ECOSYSTEM; MICROALGA; PREDICTION; TOXICITY;

ANIMAL EXPERIMENT; AQUATIC SPECIES; ARTICLE; CERIODAPHNIA DUBIA; CHRONIC TOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; ENVIRONMENTAL IMPACT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RIVER; SELENASTRUM CAPRICORNUTUM; TOXICITY TESTING; ZEBRA FISH; ADVERSE DRUG REACTION; ANIMAL; CHEMISTRY; CLADOCERA; DRUG EFFECTS; GREEN ALGA; JAPAN; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NONMAMMALIAN EMBRYO; PROCEDURES; RISK ASSESSMENT; TOXICITY; WATER POLLUTANT;

HONSHU; JAPAN; KANTO; TAMA RIVER;

ALGAE; APIS; CERIODAPHNIA DUBIA; DANIO RERIO; DAPHNIIDAE; SELENASTRUM CAPRICORNUTUM;

ANIMALS; AQUATIC ORGANISMS; CHLOROPHYTA; CLADOCERA; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; EMBRYO, NONMAMMALIAN; JAPAN; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RISK ASSESSMENT; RIVERS; TOXICITY TESTS, CHRONIC; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

EID: 84954289841     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.3285     Document Type: Article

References (44)

1. Fent K, Weston AA, Caminada D. 2006. Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122-159.
2. Brausch JM, Rand GM. 2011. A review of personal care products in the aquatic environment: Environmental concentrations and toxicity. Chemosphere 82:1518-1532.
3. Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, DeLeo PC, Dyer SD, Ericson JF, Gagné F, Giesy JP, Gouin T, Hallstrom L, Karlsson MV, Larsson DGJ, Lazorchak JM, Mastrocco F, McLaughlin A, McMaster ME, Meyerhoff RD, Moore R, Parrott JL, Snape JR, Murray-Smith R, Servos MR, Sibley PK, Straub JO, Szabo ND, Topp E, Tetreault GR, Trudeau VL, Van Der Kraak G. 2012. Pharmaceuticals and personal care products in the environment: What are the big questions? Environ Health Perspect 120:1221-1229.
4. European Medicines Evaluation Agency. 1998. Note for guidance: Environmental risk assessment for veterinary medicinal products other than GMO-containing and immunological products. EMEA/CVMP/055/96. London, UK.
5. European Medicines Evaluation Agency. 2006. Guideline on the environmental risk assessment of medicinal products for human use. Committee for Medicinal Products for Human Use. EMEA/CHMP/SWP/447/00. London, UK.
6. US Food and Drug Administration, Center for Drug Evaluation and Research. 1998. Guidance for industry, environmental assessment of human drug and biological application, Rev. 1. FDA-CMC. Rockville, MD.
7. Backhaus T. 2014. Medicines, shaken and stirred: A critical review on the ecotoxicology of pharmaceutical mixtures. Philos Trans R Soc Lond B Biol Sci 369:20130585.
8. Backhaus T, Scholze M, Grimme LH. 2000. The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri. Aquat Toxicol 49:49-61.
9. Backhaus T, Altenburger R, Boedeker W, Faust M, Scholze M, Grimme LH. 2000. Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri. Environ Toxicol Chem 19:2348-2356.
10. Silva E, Rajapakse N, Kortenkamp A. 2002. Something from "nothing"-Eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environ Sci Technol 36:1751-1756.
11. Cleuvers M. 2003. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett 142:185-194.
12. Flaherty CM, Dodson SI. 2005. Effects of pharmaceuticals on Daphnia survival, growth, and reproduction. Chemosphere 61:200-207.
13. Kortenkamp A, Backhaus T, Faust M. 2009. State of the art report on mixture toxicity. Report to the EU Commission. 070307/2007/485103/ETU/D.1. Available from: http://ec.europa.eu/environment/chemicals/effects/pdf/report_mixture_toxicity.pdf
14. Jonker MJ, Gerhardt A, Backhaus T, van Gestel CAM. Test design, mixture characterization, and data evaluation. In van Gestel CAM, Jonker MJ, Kammenga JE, Laskowski R, Svendsen C, eds, Mixture Toxicity: Linking Approaches from Ecotoxicology and Human Toxicology. SETAC/CRC, Boca Raton, FL, USA, pp 121-157.
15. Altenburger R, Walter H, Grote M. 2004. What contributes to the combined effect of a complex mixture? Environ Sci Technol 38:6353-6362.
16. Backhaus T, Porsbring T, Arrhenius Å, Brosche S, Johansson P, Blanck H. 2011. Single-substance and mixture toxicity of five pharmaceuticals and personal care products to marine periphyton communities. Environ Toxicol Chem 30:2030-2040.
17. Cleuvers M. 2004. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid. Ecotoxicol Environ Saf 59:309-315.
18. Christensen AM, Faaborg-Andersen S, Flemming I, Baun A. 2007. Mixture and single-substance toxicity of selective serotonin reuptake inhibitors toward algae and crustaceans. Environ Toxicol Chem 26:85-91.
19. Christensen AM, Ingerslev F, Baun A. 2006. Ecotoxicity of mixtures of antibiotics used in aquacultures. Environ Toxicol Chem 25:2208-2215.
20. Schnell S, Bols NC, Barata C, Porte C. 2009. Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1. Aquat Toxicol 93:244-252.
21. Parrella A, Kundi M, Lavorgna M, Criscuoloa M, Russo C, Isidori M. 2014. Toxicity of exposure to binary mixtures of four anti-neoplastic drugs in Daphnia magna and Ceriodaphnia dubia. Aquat Toxicol 157:41-46.
22. Brezovšek P, Eleršek T, Filipič M. 2014. Toxicities of four anti-neoplastic drugs and their binary mixtures tested on the green alga Pseudokirchneriella subcapitata and the cyanobacterium Synechococcus leopoliensis. Water Res 52:168-177.
23. US Environmental Protection Agency. 2002. Short-term methods for estimating the chronic toxicity of effluents and receiving waters to freshwater organisms, 4th ed. EPA 821/R-02/013. Washington DC.
24. Suzuki T. 2012. Occurrence of selected human pharmaceuticals and prediction of their environmental concentrations in the aquatic environment. Annual Report of Tokyo Metropolitan Institute of Public Health 63:69-81 (in Japanese).
25. Organisation for Economic Co-operation and Development. 2006. Test No. 201: Freshwater alga and cyanobacteria, growth inhibition test. OECD Guidelines for the Testing of Chemicals. Paris, France.
26. Kasai F, Hatakeyama S. 1993. Herbicide susceptibility in two green algae, Chlorella vulgaris and Selenastrum capricornutum. Chemosphere 27:899-904.
27. Environment Canada. 2010. Biological test method: Test of reproduction and survival using the cladoceran Ceriodaphnia dubia, 2nd ed. EPS1/RM/21. Ottawa, Canada.
28. Organisation for Economic Co-operation and Development. 1998. Test No. 212: Fish, short-term toxicity test on embryo and sac-fry stages. OECD Guidelines for the Testing of Chemicals. Paris, France.
29. Organization for Economic Co-operation and Development. 2011. Test No. 211: Daphnia magna reproduction test. OECD Guidelines for the Testing of Chemicals. Paris, France.
30. R Foundation for Statistical Computing. R: Language and Environment for Statistical Computing. Vienna, Austria. [cited 2012 October 24]. Available from http://www.R-project.org/
31. Environment Canada. 2007. Guidance document on statistical methods for environmental toxicity tests. EPS 1/RM/46. Ottawa, Canada.
32. Ritz C. 2015. Package "drc." [cited 2013 August 27]. Available from: http://cran.r-project.org/web/packages/drc/drc.pdf
33. Ritz C. 2010. Toward a unified approach to dose-response modeling in ecotoxicology. Environ Toxicol Chem 29:220-229.
34. Baumann M, Weiss K, Maletzki D, Schüssler W, Schudoma D, Kopf W, Kühnen U. 2015. Aquatic toxicity of the macrolide antibiotic clarithromycin and its metabolites. Chemosphere 120:192-198.
35. Berninger JP, Du B, Connors KA, Eytcheson SA, Kolkmeier MA, Prosser KN, Valenti TW, Chambliss CK, Brooks BW. 2011. Effects of the antihistamine diphenhydramine on selected aquatic organisms. Environ Toxicol Chem 30:2065-2072.
36. Prášková E, Voslářová E, Široká Z, Mácová S, Plhalová L, Bedáňová I, Maršálek P, Pištěková V, Svobodová Z. 2011. Comparison of acute toxicity of ketoprofen to juvenile and embryonic stages of Danio rerio. Neuroendocrinol Lett 32(Suppl. 1):101-104.
37. Kim I, Tanaka H. 2009. Photodegradation characteristics of PPCPs in water with UV treatment. Environ Int 35:793-802.
38. Vione D, Feitosa-Felizzola J, Minero C, Chiron S. 2009. Phototransformation of selected human-used macrolides in surface water: Kinetics, model predictions and degradation pathways. Water Res 43:1959-1967.
39. Salgado R, Pereira VJ, Carvalho G, Soeiro R, Gaffney V, Almeida C, Vale Cardoso V, Ferreira E, Benoliel MJ, Ternes TA, Oehmena A, Reis MAM, Noronha JP. 2013. Photodegradation kinetics and transformation products of ketoprofen, diclofenac and atenolol in pure water and treated wastewater. J Hazard Mater 244-245:516-527.
40. González-Pleiter M, Gonzalo S, Rodea-Palomares I, Leganés F, Rosal R, Boltes K, Marco E, Fernández-Piñas F. 2013. Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: Implications for environmental risk assessment. Water Res 47:2050-2064.
41. Escher BI, Hermens JLM. 2002. Modes of action in ecotoxicology: Their role in body burdens, species sensitivity, QSARs, and mixture effects. Environ Sci Technol 36:4201-4217.
42. Toms J, Lesperance ML. 2003. Piecewise regression: A tool for identifying ecological thresholds. Ecology 84:2034-2041.
43. Sunshine A, Laska EM, Siegel CE. 1991. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same. Patent US4985459 A. US Patent Office. Washington, DC. Available from: http://www.google.com/patents/US4985459
44. Pomati F, Cotsapas CJ, Castiglioni S, Zuccato E, Calamari D. 2007. Gene expression profiles in zebrafish (Danio rerio) liver cells exposed to a mixture of pharmaceuticals at environmentally relevant concentrations. Chemosphere 70:65-73.