Fine control of drug delivery for cochlear implant applications

Hearing, Balance and Communication

Volumn 13, Issue 4, 2015, Pages 153-159

  Homsy, Alexandra ^a   Laux, Edith ^a   Brossard, Julien ^a   Whitlow, Harry J ^a   Roccio, Marta ^b   Hahnewald, Stefan ^b   Senn, Pascal ^b,c   MistrÍk, Pavel ^d   Hessler, Roland ^d   Melchionna, Teresa ^d   Frick, Claudia ^e   LÖwenheim, Hubert ^e,f   MÜller, Marcus ^e,f   Wank, Ute ^g   MÜller, Karl Heinz Wies ^g   Keppner, Herbert ^a  

^a Ecole d'Ingenieurs de l'Arc Jurassien   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d MED EL GmbH   (Austria)

^e UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^f UNIVERSITY OF OLDENBURG   (Germany)

^g EMC MICROCOLLECTIONS GMBH   (Germany)

Author keywords

Cochlear Implants; Diffusion Constants; Drug Delivery Systems; Growth Factors

Indexed keywords

AGENTS ACTING ON THE AUDITORY AND VESTIBULAR SYSTEMS; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DI HYDROXYFLAVONE; FLAVONE DERIVATIVE; FLUORESCEIN; POLYMER; UNCLASSIFIED DRUG;

ACOUSTIC NERVE FIBER; ARTICLE; COCHLEA PROSTHESIS; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; FLUORESCENCE MICROSCOPY; HUMAN; INNER EAR; MOLECULAR SIZE; NERVE FIBER GROWTH; NERVOUS TISSUE; OSMOSIS; PRIORITY JOURNAL; SOLID;

EID: 84954126057     PISSN: 21695717     EISSN: 21695725     Source Type: Journal    
DOI: 10.3109/21695717.2015.1048082     Document Type: Article

References (9)

1. R, Bitsche M, Miller JM, Zhu Y, Prieskorn DM, Altschuler RA, Schrott-Fischer A. Deafferentation-Associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor. J Comp Neurol. 2008;507:1602-21.
2. Shibata SB, Cortez SR, Beyer LA, Wiler JA, Di Polo A, Pfingst BE, Raphael Y. Transgenic BDNF induces nerve fibre regrowth into the auditory epithelium in deaf cochleae. Exper Neurol. 2010;223:464-72.
3. Ramekers D, Versnel H, Grolman W, Klis SF. Neurotrophins and their role in the cochlea. Hear Res. 2012:288:19-33.
4. Yu Q, Chang Q, Liu X, Wang Y, Li H, Gong S, ET AL. Protection of Spiral Ganglion Neurons from Degeneration Using Small-Molecule TrkB Receptor Agonists. JN eurosci. 2013;33: 13042-52.
5. Fortin JB, Lu TM. Chemical vapour deposition Polymerization, the growth and properties of Parylene thin films. Kluwer Academic Publishers, ISBN 1 4020 76886.
6. Charmet J, Banakh O, Laux E, Graf B, Dias F, Dunand A, et al. Solid on liquid deposition. Thin Solid Films. 2010;518:5061-5.
7. Gorham WF. J Polym Sci Part A. Polym Chem. 1966; 4:3027-9.
8. Grattan DW. Parylene at the Canadian Conservation Institute. Can Chem News. 1989;41:25-6.
9. Open source image processing software http://developer. imagej.net/(webpage accessed on 27th February 2015).