Mindfulness in the Maintenance of Cognitive Capacities in Alzheimer's Disease: A Randomized Clinical Trial

Journal of Alzheimer's Disease

Volumn 50, Issue 1, 2016, Pages 217-232

  Quintana Hernández, Domingo J ^a   Miró Barrachina, Maria T ^a   Ibáñez Fernández, Ignacio J ^a   Santana Del Pino, Angelo ^b   Quintana Montesdeoca, Maria P ^b   Rodríguez De Vera, Bienvenida ^b   Morales Casanova, David ^a   Del Carmen Pérez Vieitez, Maria ^c   Rodríguez García, Javier ^d   Bravo Caraduje, Noelia ^d  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c Doctor Negrín University Hospital of Gran Canaria Las Palmas GC   (Spain)

^d Nursing Home El Pino   (Spain)

Author keywords

Alzheimer's disease; cognitive impairment; cognitive stimulation therapy; mindfulness; non pharmacological treatments; progressive muscle relaxation

Indexed keywords

DONEPEZIL;

AGED; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ARTICLE; CAMBRIDGE COGNITIVE EXAMINATION; CLINICAL ASSESSMENT TOOL; COGNITION; COGNITIVE DEFECT; COGNITIVE STIMULATION THERAPY; COGNITIVE THERAPY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EFFECT SIZE; FEMALE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MINDFULNESS; MINI MENTAL STATE EXAMINATION; MUSCLE RELAXATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; AGE; COGNITION DISORDERS; COMPLICATION; MENTAL HEALTH; NEUROPSYCHOLOGICAL TEST; PROCEDURES; TREATMENT OUTCOME; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; COGNITION DISORDERS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL STATUS SCHEDULE; MINDFULNESS; NEUROPSYCHOLOGICAL TESTS; TREATMENT OUTCOME;

EID: 84954091440     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-143009     Document Type: Article

References (55)

1. Tan CC, Yu JT,Wang HF, Tan MS, Meng XF,Wang C, Jiang T, Zhu XC, Tan L (2014) Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: A systematic review and meta-analysis. J Alzheimers Dis 41, 615-631.
2. Schmidt R, Hofer E, Bouwman FH, Buerger K, Cordonnier C, Fladby T, Galimberti D, Georges J, Heneka MT, Hort J, Laczó J, Molinuevo JL, O'Brien JT, Religa D, Scheltens P, Schott JM, Sorbi S (2015) EFNS-ENS/EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer's disease. Eur J Neurol 22, 889-898.
3. Gates NJ, Sachdev P (2014) Is cognitive training an effective treatment for preclinical and early Alzheimer's disease? J Alzheimers Dis 42, 551-559.
4. Olazarán J, Reisberg B, Clare L, Cruz I, Peña-Casanova J, Del Ser T,Woods B, Beck C, Auer S, Lai C, Spector A, Fazio S, Bond J, Kivipelto M, Brodaty H, Rojo JM, Collins H, Teri L, Mittelman M, Orrell M, Feldman HH, Muñiz R (2010) Nonpharmacological therapies in Alzheimer's disease:Asystematic review of efficacy. Dement Geriatr Cogn Disord 30, 161-178.
5. Andersen F,Viitanen M, Halvorsen DS, Straume B,Wilsgaard T, Engstad TA (2012) The effect of stimulation therapy and donepezil on cognitive function in Alzheimer's disease. A community based RCT with a two-by-two factorial design. BMC Neurol 12, 59.
6. Quintana Hernández DJ, Miró Barrachina MT, Ibáñez Fernández I, del Pino AS, García Rodríguez Jr, Hernández JR (2014) Effects of a neuropsychology program based on mindfulness on Alzheimer's disease: Randomized double-blind clinical study. Rev Esp Geriatr Gerontol 49, 165-172.
7. Quintana Hernández DJ, Miró Barrachina MT, Ibáñez Fernández I, Santana Del Pino A, Rojas Hernández J, Rodríguez García J, Quintana Montesdeoca Mdel P (2015) Mindfulness-based stimulation in advanced Alzheimer's disease: A comparative, non-inferiority, clinical pilot study. Rev Esp Geriatr Gerontol 50, 168-173.
8. Kabat-Zinn J (2013) Full Catastrophe Living (Revised Edition): Using theWisdom of Your Body and Mind toFace Stress, Pain, and Illness, Bantam, New York.
9. Hughes JW, Fresco DM,Myerscough R,HMvan Dulmen M, Carlson LE, Josephson R (2013) Randomized controlled trial of mindfulness-based stress reduction for prehypertension. Psychosom Med 75, 721-728.
10. Strauss C, Cavanagh K, Oliver A, Pettman D (2014) Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: A meta-analysis of randomised controlled trials. PLoS One 9, 96-110.
11. Teasdale JD, Segal ZV,Williams JM, Ridgeway VA, Soulsby JM, Lau MA (2000) Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol 68, 615-623.
12. Davidson RJ, Kabat-Zinn J, Schumacher J, Rosenkranz M, Muller D, Santorelli SF, Urbanowski F, Harrington A, Bonus K, Sheridan JF (2003) Alterations in brain and immune function produced by mindfulness meditation. Psychosom Med 65, 564-570.
13. Rosenkranz MA, Davidson RJ, Maccoon DG, Sheridan JF, Kalin NH, Lutz A (2013) A comparison of mindfulnessbased stress reduction and an active control in modulation of neurogenic inflammation. Brain Behav Immun 27, 174-184.
14. Lazar SW, Kerr CE, Wasserman RH, Gray JR, Greve DN, Treadway MT, Fischl B (2005) Meditation experience is associated with increased cortical thickness. Neuroreport 16, 1893-1897.
15. Hölzel BK, Carmody J, Vangel M, Congleton C, Yerramsetti SM, Gard T, Lazar SW (2011) Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res 191, 36-43.
16. Shaurya Prakash R, De Leon AA, Klatt M, Malarkey W, Patterson B (2013) Mindfulness disposition and defaultmode network connectivity in older adults. Soc Cogn Affect Neurosci 8, 112-117.
17. Moore A, Gruber T, Derose J, Malinowski P (2012) Regular, brief mindfulness meditation practice improves electrophysiological markers of attentional control. Front Hum Neurosci 10, 6-18.
18. Farb NAS, Segal ZV, Anderson AK (2013) Mindfulness meditation training alters cortical representations of interoceptive attention. Soc Cogn Affect Neurosci 8, 15-26.
19. Tang YY, Posner MI, Rothbart MK (2013) Meditation improves self-regulation over the life span. Ann N Y Acad Sci 1307, 104-111.
20. Fox KC, Nijeboer S, Dixon ML, Floman JL, Ellamil M, Rumak SP, Sedlmeier P, Christoff K (2014) Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners. Neurosci Biobehav Rev 43, 48-73.
21. Tang YY, Hölzel BK, Posner MI (2015) The neuroscience of mindfulness meditation. Nat Rev Neurosci 16, 213-225.
22. Larouche E, Hudon C, Goulet S (2015) Potential benefits of mindfulness-based interventions in mild cognitive impairment and Alzheimer's disease: An interdisciplinary perspective. Behav Brain Res 276, 199-212.
23. Wells RE, Yeh GY, Kerr CE, Wolkin J, Davis RB, Tan Y, Spaeth R, Wall RB, Walsh J, Kaptchuk TJ, Press D, Phillips RS, Kong J (2013) Meditation's impact on default mode network and hippocampus in mild cognitive impairment: A pilot study. Neurosci Lett 556, 15-19.
24. Wells RE, Kerr CE, Wolkin J, Dossett M, Davis RB, Walsh J, Wall RB, Kong J, Kaptchuk T, Press D, Phillips RS, Yeh G (2013) Meditation for adults with mild cognitive impairment: A pilot randomized trial. J Am Geriatr Soc 61, 642-645.
25. Hyer L, Scott C, Lyles J, Dhabliwala J, McKenzie L (2014) Memory intervention: The value of a clinical holistic program for older adults with memory impairments. Aging Ment Health 18, 169-178.
26. Innes KE, Selfe TK, Brown CJ, Rose KM, Thompson-Heisterman A (2012) The effects of meditation on perceived stress and related indices of psychological status and sympathetic activation in persons with Alzheimer's disease and their caregivers: A pilot study. Evid Based Complement Alternat Med 2012, 927509.
27. Newberg AB, Wintering N, Khalsa DS, Roggenkamp H, Waldman MR (2010) Meditation effects on cognitive function and cerebral blood flow in subjects with memory loss: A preliminary study. J Alzheimers Dis 20, 517-526.
28. Chapman SB, Weiner MF, Rackley A, Hynan LS, Zientz J (2004) Effects of cognitive-communication stimulation for Alzheimer's disease patients treated with donepezil. J Speech Lang Hear Res 47, 1149-1163.
29. Matsuda O (2007) Cognitive stimulation therapy for Alzheimer's disease: The effect of cognitive stimulation therapy on the progression of mild Alzheimer's disease in patients treated with donepezil. Int Psychogeriatr 19, 241-252.
30. Matsuda O, Shido E, Hashikai A, Shibuya H, Kouno M, Hara C, SaitoM(2010) Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease. Psychogeriatrics 10, 167-172.
31. Andersen F, Viitanen M, Halvorsen DS, Straume B, Wilsgaard T, Engstad TA (2012) The effect of stimulation therapy and donepezil on cognitive function in Alzheimer's disease. A community based RCT with a two-by-two factorial design. BMC Neurol 12, 59.
32. Suhr J, Anderson S, Tranel D (1999) Progressive muscle relaxation in the management of behavioural disturbance in Alzheimer's disease. Neuropsychol Rehabil 9, 31-44.
33. Boutron I, Moher D, Altman DG, Schulz KF,Ravaud P (2008) CONSORT Group. Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: Explanation and elaboration. Ann Intern Med 148, 295-309.
34. Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG (2010) CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. BMJ 340, 869.
35. Roth M, Huppert FA, Mountjoy CQ,TymE(2003) CAMDEXR. Revised Cambridge Screening Test for the Assessment of Mental Disorders in the Elderly (Adapted by López-Pousa S) , TEA, Madrid.
36. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease report of the NINCDS-ADRDA work group∗ under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 34, 939-939.
37. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G,Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 6, 734-746.
38. Reisberg B, Ferris SH, de Leon MJ, Crook T (1988) Global Deterioration Scale (GDS) . Psychopharmacol Bull 24, 661-663.
39. Bond M, Rogers G, Peters J, Anderson R, Hoyle M, Miners A, Moxham T, Davis S, Thokala P,Wailoo A, Jeffreys M, HydeC (2012) The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): A systematic review and economic model. Health Technol Assess 16, 1-470.
40. Loveman E, Green C, Kirby J, Takeda A, Picot J, Payne E, Clegg A (2006) The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease. Health Technol Assess 10, 1-160.
41. Lanctôt KL, Rajaram RD, Herrmann N (2009) Therapy for Alzheimer's disease: How effective are current treatments? Ther Adv Neurol Disord 2, 163-180.
42. Cappell J, Herrmann N, Cornish S, Lanctôt KL (2010) The pharmacoeconomics of cognitive enhancers in moderate to severe Alzheimer's disease. CNS Drugs 24, 909-927.
43. Tárraga L, Boada M (2003) Cuadernos de repaso: Ejercicios prácticos de estimulación cognitiva para enfermos de Alzheimer en fase moderada, Glosa, Barcelona.
44. Tárraga L (1998) Soft therapies: The Programme of Integral Psychostimulation. Alternative treatment for persons with Alzheimer's disease. Rev Neurol 27, 51-62.
45. Vidovich MR, Shaw J, Flicker L, Almeida OP (2011) Cognitive activity for the treatment of older adults with mild Alzheimer's disease (AD)-PACE AD: Study protocol for a randomised controlled trial. Trials 12, 47.
46. Smith JC,Wedell AB,Kolotylo CJ, Lewis JE, ByersKY, Segin CM (2000) ABC relaxation theory and the factor structure of relaxation states, recalled relaxation activities, dispositions, and motivations. Psychol Rep 86, 1201-1208.
47. Matsumoto M, Smith JC (2001) Progressive muscle relaxation, breathing exercises, and ABC relaxation theory. J Clin Psychol 57, 1551-1557.
48. McBee L (2008) Mindfulness-Based Elder Care: A Cam Model for Frail Elders and Their Caregivers, Springer Publishing Company, New York.
49. Armendia JL (2009) Chair yoga, Hiria, Donostia.
50. Ayres AJ (1972) Improving academic scores through sensory integration. J Learn Disabil 5, 338-343.
51. Ayres AJ, Mailloux Z (1981) Influence of sensory integration procedures on language development. Am J Occup Ther 35, 383-390.
52. Dominguez Lara S (2014) Effect size: Calculation using a visual basic module. Rev Investig Psicol 16, 235-240.
53. Spector A, Thorgrimsen L, Woods B, Royan L, Davies S, Butterworth M, Orrell M (2003) Efficacy of an evidencebased cognitive stimulation therapy programme for people with dementia. Br J Psychiatry 183, 248-254.
54. Spector A, Orrell M, Hall L (2012) Systematic review of neuropsychological outcomes in dementia from cognition-based psychological interventions. Dement Geriatr Cogn Disord 34, 244-255.
55. Wouters H, van Gool WA, Schmand B, Zwinderman AH, Lindeboom R (2010) Three sides of the same coin: Measuring global cognitive impairment with the MMSE, ADAS-cog and CAMCOG. Int J Geriatr Psychiatry 25, 770-779.