Bone Geometry, Volumetric Density, Microarchitecture, and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients with Type 1 Diabetes Mellitus

Journal of Bone and Mineral Research

Volumn 30, Issue 12, 2015, Pages 2188-2199

  Shanbhogue, Vikram V ^a,b   Hansen, Stinus ^a,b   Frost, Morten ^a,b   Jørgensen, Niklas Rye ^b,c   Hermann, Anne Pernille ^a,b   Henriksen, Jan Erik ^a,b   Brixen, Kim ^a,b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c University of Copenhagen   (Denmark)

Author keywords

BONE MICROARCHITECTURE; HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; MICROVASCULAR DISEASE; TYPE 1 DIABETES MELLITUS

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BIOCHEMICAL MARKER; C PEPTIDE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOCORTICOID; GLUTAMATE DECARBOXYLASE; GLYCOSYLATED HEMOGLOBIN; INSULIN; THIAZIDE DIURETIC AGENT;

ADULT; ARTICLE; BIOCHEMICAL ANALYSIS; BODY HEIGHT; BODY MASS; BONE DENSITY; BONE MICROARCHITECTURE; BONE REMODELING; BONE STRENGTH; BONE STRUCTURE; BONE TURNOVER; CLINICAL ASSESSMENT; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; CROSS-SECTIONAL STUDY; DIABETIC MICROANGIOPATHY; DISEASE DURATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GEOMETRY; GLYCEMIC CONTROL; HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; HUMAN; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; RADIUS; TIBIA; TRABECULAR BONE; VOLUMETRY; ADOLESCENT; ANTHROPOMETRY; BONE; CASE CONTROL STUDY; CHILD; COMPLICATION; DIAGNOSTIC IMAGING; MICROCIRCULATION; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; VASCULAR DISEASE; X-RAY COMPUTED TOMOGRAPHY; YOUNG ADULT;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; ADULT; ANTHROPOMETRY; BODY MASS INDEX; BONE AND BONES; BONE DENSITY; BONE REMODELING; CASE-CONTROL STUDIES; CHILD; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; RADIUS; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; VASCULAR DISEASES; YOUNG ADULT;

EID: 84954077913     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2573     Document Type: Article

References (43)

1. Hamilton EJ, Rakic V, Davis WA, et al., Prevalence and predictors of osteopenia and osteoporosis in adults with Type 1 diabetes. Diabet Med. 2009; 26 (1): 45-52.
2. Alexopoulou O, Jamart J, Devogelaer JP, Brichard S, de Nayer P, Buysschaert M., Bone density and markers of bone remodeling in type 1 male diabetic patients. Diabetes Metab. 2006; 32 (5 Pt 1): 453-8.
3. Kemink SA, Hermus AR, Swinkels LM, Lutterman JA, Smals AG., Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology. J Endocrinol Invest. 2000; 23 (5): 295-303.
4. Vestergaard P., Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int. 2007; 18 (4): 427-44.
5. Ingberg CM, Palmer M, Aman J, Arvidsson B, Schvarcz E, Berne C., Body composition and bone mineral density in long-standing type 1 diabetes. J Intern Med. 2004; 255 (3): 392-8.
6. Lunt H, Florkowski CM, Cundy T, et al., A population-based study of bone mineral density in women with longstanding type 1 (insulin dependent) diabetes. Diabetes Res Clin Pract. 1998; 40 (1): 31-8.
7. Vestergaard P., Anti-resorptive therapy for the prevention of postmenopausal osteoporosis: when should treatment begin? Treat Endocrinol. 2005; 4 (5): 263-77.
8. Campos Pastor MM, Lopez-Ibarra PJ, Escobar-Jimenez F, Serrano Pardo MD, Garcia-Cervigon AG., Intensive insulin therapy and bone mineral density in type 1 diabetes mellitus: a prospective study. Osteoporos Int. 2000; 11 (5): 455-9.
9. Munoz-Torres M, Jodar E, Escobar-Jimenez F, Lopez-Ibarra PJ, Luna JD., Bone mineral density measured by dual X-ray absorptiometry in Spanish patients with insulin-dependent diabetes mellitus. Calcif Tissue Int. 1996; 58 (5): 316-9.
10. Rix M, Andreassen H, Eskildsen P., Impact of peripheral neuropathy on bone density in patients with type 1 diabetes. Diabetes Care. 1999; 22 (5): 827-31.
11. Miao J, Brismar K, Nyren O, Ugarph-Morawski A, Ye W., Elevated hip fracture risk in type 1 diabetic patients: a population-based cohort study in Sweden. Diabetes Care. 2005; 28 (12): 2850-5.
12. Bridges MJ, Moochhala SH, Barbour J, Kelly CA., Influence of diabetes on peripheral bone mineral density in men: a controlled study. Acta Diabetol. 2005; 42 (2): 82-6.
13. Lumachi F, Camozzi V, Tombolan V, Luisetto G., Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus. Ann N Y Acad Sci. 2009; 1173 Suppl 1: E64-7.
14. Armas LA, Akhter MP, Drincic A, Recker RR., Trabecular bone histomorphometry in humans with type 1 diabetes mellitus. Bone. 2012; 50 (1): 91-6.
15. Fassbender WJ, Godde M, Brandenburg VM, Usadel KH, Stumpf UC., Urinary bone resorption markers (deoxypyridinoline and C-terminal telopeptide of type I collagen) in healthy persons, postmenopausal osteoporosis and patients with type I diabetes. Adv Med Sci. 2009; 54 (1): 1-6.
16. Miazgowski T, Czekalski S., A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus. Osteoporos Int. 1998; 8 (5): 399-403.
17. Hansen S, Shanbhogue V, Folkestad L, Nielsen MM, Brixen K., Bone microarchitecture and estimated strength in 499 adult Danish women and men: a cross-sectional, population-based high-resolution peripheral quantitative computed tomographic study on peak bone structure. Calcif Tissue Int. 2014; 94 (3): 269-81.
18. Boutroy S, Bouxsein ML, Munoz F, Delmas PD., In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005; 90 (12): 6508-15.
19. Laib A, Ruegsegger P., Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone. 1999; 24 (1): 35-9.
20. Laib A, Hauselmann HJ, Ruegsegger P., In vivo high resolution 3D-QCT of the human forearm. Technol Health Care. 1998; 6 (5-6): 329-37.
21. Laib A, Hildebrand T, Hauselmann HJ, Ruegsegger P., Ridge number density: a new parameter for in vivo bone structure analysis. Bone. 1997; 21 (6): 541-6.
22. Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS., Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. 1983; 72 (4): 1396-409.
23. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S., Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia. J Bone Miner Res. 2010; 25 (5): 983-93.
24. Nishiyama KK, Macdonald HM, Buie HR, Hanley DA, Boyd SK., Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res. 2010; 25 (4): 882-90.
25. Pistoia W, van Rietbergen B, Lochmuller EM, Lill CA, Eckstein F, Ruegsegger P., Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside. J Clin Densitom. 2004; 7 (2): 153-60.
26. Macneil JA, Boyd SK., Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone. 2008; 42 (6): 1203-13.
27. Pialat JB, Burghardt AJ, Sode M, Link TM, Majumdar S., Visual grading of motion induced image degradation in high resolution peripheral computed tomography: impact of image quality on measures of bone density and micro-architecture. Bone. 2012; 50 (1): 111-8.
28. Hansen S, Hauge EM, Beck Jensen JE, Brixen K., Differing effects of PTH 1-34, PTH 1-84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: an 18-month open-labeled observational study using HR-pQCT. J Bone Miner Res. 2013; 28 (4): 736-45.
29. Bechtold S, Putzker S, Bonfig W, Fuchs O, Dirlenbach I, Schwarz HP., Bone size normalizes with age in children and adolescents with type 1 diabetes. Diabetes Care. 2007; 30 (8): 2046-50.
30. McNair P, Christiansen C, Christensen MS, et al., Development of bone mineral loss in insulin-treated diabetes: a 1 1/2 years follow-up study in sixty patients. Eur J Clin Invest. 1981; 11 (1): 55-9.
31. Vestergaard P, Rejnmark L, Mosekilde L., Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes. Calcif Tissue Int. 2009; 84 (1): 45-55.
32. Seeman E, Delmas PD., Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med. 2006; 354 (21): 2250-61.
33. Verhaeghe J, Visser WJ, Einhorn TA, Bouillon R., Osteoporosis and diabetes: lessons from the diabetic BB rat. Horm Res. 1990; 34 (5-6): 245-8.
34. Krakauer JC, McKenna MJ, Buderer NF, Rao DS, Whitehouse FW, Parfitt AM., Bone loss and bone turnover in diabetes. Diabetes. 1995; 44 (7): 775-82.
35. Saag KG, Shane E, Boonen S, et al., Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007; 357 (20): 2028-39.
36. Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP., Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab. 2000; 85 (9): 3069-76.
37. Shanbhogue VV, Hansen S, Folkestad L, Brixen K, Beck-Nielsen SS., Bone geometry, volumetric density, microarchitecture, and estimated bone strength assessed by HR-pQCT in adult patients with hypophosphatemic rickets. J Bone Miner Res. 2015; 30 (1): 176-83.
38. Goh SY, Cooper ME., Clinical review: the role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 2008; 93 (4): 1143-52.
39. Saito M, Marumo K., Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int. 2010; 21 (2): 195-214.
40. Olmos JM, Perez-Castrillon JL, Garcia MT, Garrido JC, Amado JA, Gonzalez-Macias J., Bone densitometry and biochemical bone remodeling markers in type 1 diabetes mellitus. Bone Miner. 1994; 26 (1): 1-8.
41. Valerio G, del Puente A, Esposito-del Puente A, Buono P, Mozzillo E, Franzese A., The lumbar bone mineral density is affected by long-term poor metabolic control in adolescents with type 1 diabetes mellitus. Horm Res. 2002; 58 (6): 266-72.
42. Heap J, Murray MA, Miller SC, Jalili T, Moyer-Mileur LJ., Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus. J Pediatr. 2004; 144 (1): 56-62.
43. Moyer-Mileur LJ, Dixon SB, Quick JL, Askew EW, Murray MA., Bone mineral acquisition in adolescents with type 1 diabetes. J Pediatr. 2004; 145 (5): 662-9.