Frailty: A costly phenomenon in caring for elders with cognitive impairment

International Journal of Geriatric Psychiatry

Volumn 31, Issue 2, 2016, Pages 161-168

  Butler, Aine ^a   Gallagher, Damien ^a   Gillespie, Paddy ^b   Crosby, Lisa ^a   Ryan, Deirdre ^a   Lacey, Loretto ^c   Coen, Robert ^a   O'Shea, Eamon ^b   Lawlor, Brian ^a  

^a ST JAMES S HOSPITAL   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c Janssen Alzheimer Immunotherapy   (Ireland)

Author keywords

cognitive impairment; frailty; healthcare costs

Indexed keywords

ADULT; AGED; ARTICLE; COGNITIVE DEFECT; COMORBIDITY; COST BENEFIT ANALYSIS; COST CONTROL; DISEASE ASSOCIATION; ELDERLY CARE; FEMALE; FRAIL ELDERLY; HEALTH CARE COST; HUMAN; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SOCIAL CARE; ANALYSIS OF VARIANCE; CAREGIVER; COST OF ILLNESS; CROSS-SECTIONAL STUDY; ECONOMICS; MIDDLE AGED; NORTHERN IRELAND; STATISTICS AND NUMERICAL DATA;

AGED; ANALYSIS OF VARIANCE; CAREGIVERS; COGNITION DISORDERS; COST OF ILLNESS; CROSS-SECTIONAL STUDIES; FEMALE; FRAIL ELDERLY; HEALTH CARE COSTS; HUMANS; MALE; MIDDLE AGED; NORTHERN IRELAND;

EID: 84954076025     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.4306     Document Type: Article

References (49)

1. Antonucci TC, Lansford JE, Schaberg L, et al., 2001. Widowhood and illness: a comparison of social network characteristics in France, Germany, Japan and the United States. Psychol Aging 16 (4): 655-665.
2. Avila-Funes JA, Amieva H, Barberger-Gateau P, et al., 2009. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three city study. J Am Geriatr Soc 57: 453-461.
3. Ballard CG, O'Brien JT, Reichelt K, Perry EK,. 2002. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double blind, placebo-controlled trial. J Clin Psychiatr 63: 553-558.
4. Bandeen-Roche K, Xue QL, Ferrucci L, et al., 2006. Phenotype of frailty: characterization in the Women's Health and Ageing Studies. J Gerontol A Biol Sci Med Sci 61A: 262-266.
5. Bilotta C, Bergamaschini L, Nicolini P, et al., 2012. Frailty syndrome diagnosed according to the Study of Osteoporotic Fractures criteria and mortality in older outpatients suffering from Alzheimer's disease: a one-year prospective cohort study. Aging Ment Health 16 (3): 273-280.
6. Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA,. 2010. Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc 58 (2): 248-255.
7. Brodaty H, Luscombe G,. 1998. Psychological morbidity in caregivers is associated with depression in patients with dementia. Alzheimer Dis Assoc Disord 12: 62-70.
8. Buchman A, Boyle PA, Wilson RS, Tang Y, Bennett DA,. 2007. Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom Med 69 (5): 483-489.
9. Campbell AJ, Buchner DM,. 1997. Unstable disability and the fluctuations of frailty. Age Ageing 26: 315-318.
10. Conroy S,. 2009. Editorial: Defining frailty-the holy grail of geriatric medicine. J Nutr Health Aging 13 (4): 389.
11. CSO. 2010. Inflation Indices. Central Statistics Office: Dublin.
12. Cummings JL, Mega M, Gray K, et al., 1994. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44 (12): 2308-2314.
13. Drummond MF, Sculpher MJ, Torrance GW, O'Brien J, Stoddart GL,. 2005. Methods for the Economic Evaluation of Healthcare Programmes. Oxford University Press: Oxford.
14. Eng C, Pedulla J, Eleazer GP, McCann R, Fox N,. 1997. Program of All-inclusive Care for the Elderly (PACE): an innovative model of integrated geriatric care and financing. J Am Geriatr Soc 45 (2): 223-232.
15. Ferrucci L,. 2004. Designing randomized controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc 52: 625-634.
16. Folsom AR, Jacobs DR, Caspersen CJ, Gomez-Marin O, Knudsen J,. 1986. Test-retest reliability of the Minnesota Leisure Time Physical Activity Questionnaire. J Chronic Dis 39 (7): 505-511.
17. Fried LP, Tangen CM, Walston J, et al., 2001a. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 (3): 46-57.
18. Fried LP, Tangen CM, Walston J, et al., 2001c. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 (3): M146-156.
19. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G,. 2004. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59 (3): 255-263.
20. Frieswijk N, Buunk BP, Steverink N, Slaets JP,. 2004. The interpretation of social comparison and its relation to life satisfaction among frail elderly people: does frailty make a difference? J Gerontol B Psychol Sci Soc Sci 59B: 250-257.
21. Gelinas I, Gauthier L, McIntyre M, Gauthier S,. 1999. Development of a functional measure for persons with Alzheimer's disease: the disability assessment for dementia. Am J Occup Ther 53 (5): 471-481.
22. Gillespie P, O'Shea E, Cullinan J, et al., 2013. The effects of dependence and function on costs of care for Alzheimer's disease and mild cognitive impairment in Ireland. Int J Geriatr Psychiatry 28 (3): 256-264.
23. Gillespie P, O'Shea E, Cullinan J, et al., 2015. Longitudinal costs of caring for people with Alzheimer's disease. Int Psychogeriatr 27 (5): 847-856.
24. Hughes JC, Robinson L, Volicer L,. 2005. Specialist palliative care in dementia. BMJ 330 (7482): 57-58.
25. Ko FC,. 2011. The clinical care of frail, older adults. Clin Geriatr Med 27 (1): 89-100.
26. Kulmala J, Nykanen I, Manty M, Hartikainen S,. 2014. Association between frailty and dementia: a population-based study. Gerontology 60 (1): 16-21.
27. Landefeld CS, Palmer RM, Kresevic DM, Fortinsky RH, Kowal J,. 1995. A randomized trial of care in a hospital medical unit especially designed to improve the functional outcomes of acutely ill older patients. N Engl J Med 332 (20): 1338-1344.
28. Langa KM, Chernew ME, Kabeto MU, et al., 2001. National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J Gen Intern Med 16: 770-778.
29. MacGregor P, O'Neill C,. 2007. Comparing utilisation of health services on the island of Ireland. The Provision and Use of Health Services, Health Inequalities and Health and Social Gain, Nolan B, (ed.) The Economic and Social Research Institute: Dublin.
30. McKhann G, Drachman D, Folstein M, et al., 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 (7): 939-944.
31. Mittelman MS, Roth DL, Coon DW, Haley WE,. 2004. Sustained benefit of supportive intervention for depressive symptoms in caregivers of patients with Alzheimer's disease. Am J Psychiatr 161: 850-856.
32. Moise P, Schwarzinger M, Um M,. 2004. The Dementia Experts' Group: dementia care in 9 OECD countries. A comparative analysis. OECD Health Working Papers.
33. Murray J, Schneider J, Nanerjee S, Mann A,. 1999. EUROCARE: a crossnational study of co-resident spouse carers for people with Alzheimer's disease-a qualitative analysis of the experience of caregiving. Int J Geriatr Psychiatry 14 (8): 662-667.
34. Ory MG, Schechtman KB, Miller JP, et al., 1993. Frailty and injuries in later life. The FICSIT trials. J Am Geriatr Soc 41: 283-296.
35. Radloff LS,. 1977. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1: 385-401.
36. Rockwood K, Fox RA, Stolee P, Robertson D, Beattie BL,. 1994. Frailty in elderly people: an evolving concept. CMAJ 150 (4): 489-495.
37. Rockwood K, Song X, MacKnight C, et al., 2005. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J 173: 489-495.
38. Sampson EL,. 2012. Frailty and dementia: common but complex comorbidities. Aging Ment Health 16 (3): 269-272.
39. Schneider J, Murray J, Banerjee S, Mann A,. 1999. Eurocare: a cross-national study of co-resident spouse caters for people with Alzheimer's disease: factors associated with carer burden. Int J Geriatr Psychiatry 14 (8): 651-661.
40. Stern Y, Albert SM, Sano M, et al., 1994. Assessing patient dependence in Alzheimer's disease. J Gerontol 49 (5): M216-222.
41. Strawbridge WJ, Shema SJ, Balfour JL, Higby HR, Kaplan GA,. 1998. Antecedents of frailty over three decades in an older cohort. J Gerontol Soc Sci 53B: S9-S16.
42. Waite LM, Grayson DA, Piquet O, et al., 2005. Gait slowing as a predictor of incident dementia: 6 year longitudinal data from the Sydney Older Persons Study. J Neurol Sci 229-230: 89-93.
43. Walston JD, Fried LP,. 2003. Frailty and its implications for care. In Geriatric Palliative Care, Morrison RS, Meir DE, (eds.). Oxford University Press: New York.
44. Weaver FM, Hickey EC, Hughes SL, et al., 2008. Providing all-inclusive care for frail elderly veterans: evaluation of three models of care. J Am Geriatr Soc 56 (2): 345-353.
45. Wimo AW, Winblad B,. 2003. Resource utilization in dementia: RUD Lite. Brain Aging 3 (1): 48-59.
46. Wimo A, Winblad B, Jonsson L,. 2007. An estimate of the total worldwide societal costs of dementia in 2005. Alzheimers Dement 3: 81-91.
47. Winblad B, Palmer K, Kivipelto M, et al., 2004. Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 256 (3): 240-246.
48. Zarit SH, Gaugler JE, Jarrott SE,. 1999. Useful services for families: research findings and directions. Int J Geriatr Psychiatry 14: 165-177.
49. Zhu CW, Liebman C, McLaughlin T, et al., 2008. Patient dependence and longitudinal changes in costs of care in Alzheimer's disease. Dement Geriatr Cogn Disord 26 (5): 416-423.