Increase of methanol in exhaled breath quantified by SIFT-MS following aspartame ingestion

Journal of Breath Research

Volumn 9, Issue 4, 2015, Pages

  Španěl, Patrik ^a   Dryahina, Kseniya ^a   Vicherková, Petra ^a   Smith, David ^b  

^a J HEYROVSKÝ INSTITUTE OF PHYSICAL CHEMISTRY   (Czech Republic)

^b KEELE UNIVERSITY   (United Kingdom)

Author keywords

aspartame; methanol; selected ion flow tube mass spectrometry (SIFTMS); volatile metabolites

Indexed keywords

ASPARTAME; METHANOL;

ADULT; ALCOHOL BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DILUTION; EXHALATION; FEMALE; HUMAN; HUMAN EXPERIMENT; INGESTION; MALE; MASS SPECTROMETRY; NORMAL HUMAN; NOSE BREATHING; PRIORITY JOURNAL; SELECTED ION FLOW TUBE MASS SPECTROMETRY; TOTAL BODY WATER; BREATH ANALYSIS; CLINICAL TRIAL; MIDDLE AGED; MOUTH; PROCEDURES; TIME FACTOR; YOUNG ADULT;

ADULT; ASPARTAME; BREATH TESTS; EXHALATION; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; METHANOL; MIDDLE AGED; MOUTH; TIME FACTORS; YOUNG ADULT;

EID: 84953931450     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/9/4/047104     Document Type: Article

References (19)

1. Amann A and Smith D 2005 Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring (Singapore: World Scientific) p 536
2. Amann A and Smith D 2013 Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine (Boston, MA: Elsevier)
3. Butchko H H et al 2002 Aspartame: review of safety Regulatory Toxicol. Pharmacol. 35 S1-93
4. Dorokhov Y L, Shindyapina A V, Sheshukova E V and Komarova T V 2015 Metabolic methanol: molecular pathways and physiological roles Physiol. Rev. 95 603-44
5. Shaywitz B A, Sullivan C M, Anderson G M, Gillespie S M, Sullivan B and Shaywitz S E 1994 Aspartame, behavior, and cognitive function in children with attention-deficit disorder Pediatrics 93 70-5
6. Magnuson B A, Burdock G A, Doull J, Kroes R M, Marsh G M, Pariza M W, Spencer P S, Waddell W J, Walker R and Williams G M 2007 Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies Crit. Rev. Toxicol. 37 629-727
7. Schernhammer E S, Bertrand K A, Birmann B M, Sampson L, Willett W C and Feskanich D 2012 Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women Am. J. Clin. Nutr. 96 1419-28
8. Humphries P, Pretorius E and Naude H 2008 Direct and indirect cellular effects of aspartame on the brain Eur. J. Clin. Nutr. 62 451-62
9. Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X, Fernandez-Lopez J and Alemany M 1998 Formaldehyde derived from dietary aspartame binds to tissue components in vivo Life Sci. 63 337-49
10. Davoli E, Cappellini L, Airoldi L and Fanelli R 1986 Serum methanol concentrations in rats and in men after a single dose of aspartame Food Chem. Toxicol. 24 187-9
11. Sprung R, Bonte W and Lesch O M 1988 Methanol - a neglected constituent of all alcoholic beverages - a new biochemical approach to the problem of chronic-alcoholism Wiener Klinische Wochenschrift 100 282-8
12. Stegink L D, Brummel M C, McMartin K, Martinamat G, Filer L J, Baker G L and Tephly T R 1981 Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame J. Toxicol. Environ. Health 7 281-90
13. Stegink L D, Filer L J, Bell E F, Ziegler E E and Tephly T R 1989 Effect of repeated ingestion of aspartame-sweetened beverage on plasma amino-acid, blood methanol, and blood formate concentrations in normal adults Metabolism 38 357-63
14. Eriksen S P 1963 Methanol in normal human breath Science 141 639
15. Taucher J, Lagg A, Hansel A, Vogel W and Lindinger W 1995 Methanol in human breath Alcohol. Clin. Exp. Res. 19 1147-50
16. Lindinger W, Taucher J, Jordan A, Hansel A and Vogel W 1997 Endogenous production of methanol after the consumption of fruit Alcohol. Clin. Exp. Res. 21 939-43
17. Fenske J D and Paulson S E 1999 Human breath emissions of VOCs J. Air Waste Manag. Assoc. 49 594-8
18. Cap P, Dryahina K, Pehal F and Španěl P 2008 Selected ion flow tube mass spectrometry of exhaled breath condensate headspace Rapid Commun. Mass Spectrom. 22 2844-50
19. Wang T S, Pysanenko A, Dryahina K, Španěl P and Smith D 2008 Analysis of breath, exhaled via the mouth and nose, and the air in the oral cavity J. Breath Res. 2 037013