GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury

GLIA

Volumn 64, Issue 2, 2016, Pages 287-299

  Viganò, Francesca ^a,b   Schneider, Sarah ^a   Cimino, Mauro ^c   Bonfanti, Elisabetta ^d   Gelosa, Paolo ^d,e   Sironi, Luigi ^d,e   Abbracchio, Maria P ^d   Dimou, Leda ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF URBINO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e CENTRO CARDIOLOGICO MONZINO   (Italy)

Author keywords

Differentiation; Ischemia; Oligodendrocyte progenitors; Oligodendrogenesis; Repair

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 17; UNCLASSIFIED DRUG; ANTIGEN; CHONDROITIN SULFATE PROTEOGLYCAN 4; ENHANCED GREEN FLUORESCENT PROTEIN; GPR17 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; NERVE PROTEIN; PROTEOGLYCAN; SOX10 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN INJURY; BRAIN ISCHEMIA; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE REPAIR; ANIMAL; BRAIN; CEREBRAL ARTERY DISEASE; DISEASE MODEL; GENETICS; METABOLISM; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; OLIGODENDROGLIA; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS; BRAIN; BRAIN INJURIES; BRAIN ISCHEMIA; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GREEN FLUORESCENT PROTEINS; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NEUROGENESIS; OLIGODENDROGLIA; PROTEOGLYCANS; RECEPTORS, G-PROTEIN-COUPLED; SOXE TRANSCRIPTION FACTORS;

EID: 84953836427     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22929     Document Type: Article

References (30)

1. Bardehle S, Kruger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M. 2013. Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nat Neurosci 16:580-586.
2. Boda E, Di Maria S, Rosa P, Taylor V, Abbracchio MP, Buffo A. 2015. Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors. Glia 63:271-286.
3. Boda E, Vigano F, Rosa P, Fumagalli M, Labat-Gest V, Tempia F, Abbracchio MP, Dimou L, Buffo A. 2011. The GPR17 receptor in NG2 expressing cells: Focus on in vivo cell maturation and participation in acute trauma and chronic damage. Glia 59:1958-1973.
4. Chen Y, Wu H, Wang S, Koito H, Li J, Ye F, Hoang J, Escobar SS, Gow A Arnett HA, et al. 2009. The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci 12:1398-1406.
5. Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V Gelosa P, et al. 2006. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J 25:4615-4627.
6. Dimou L, Gotz M. 2014. Glial cells as progenitors and stem cells: New roles in the healthy and diseased brain. Physiol Rev 94:709-737.
7. Dimou L, Simon C, Kirchhoff F, Takebayashi H, Gotz M. 2008. Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci 28:10434-10442.
8. Eberini I, Daniele S, Parravicini C, Sensi C, Trincavelli ML, Martini C, Abbracchio MP. 2011. In silico identification of new ligands for GPR17: A promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des 25:743-752.
9. Franklin RJ, Gallo V. 2014. The translational biology of remyelination: Past, present, and future. Glia 62:1905-1915.
10. Fumagalli M, Daniele S, Lecca D, Lee PR, Parravicini C, Fields RD, Rosa P, Antonucci F, Verderio C Trincavelli ML, et al. 2011. Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J Biol Chem 286:10593-10604.
11. Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A. 2014. Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division. Nat Neurosci 17:1518-1527.
12. Hill RA, Patel KD, Medved J, Reiss AM, Nishiyama A. 2013. NG2 cells in white matter but not gray matter proliferate in response to PDGF. J Neurosci 33:14558-14566.
13. Hughes EG, Kang SH, Fukaya M, Bergles DE. 2013. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci 16:668-676.
14. Kang SH, Fukaya M, Yang JK, Rothstein JD, Bergles DE. 2010. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 68:668-681.
15. Kessaris N, Fogarty M, Iannarelli P, Grist M, Wegner M, Richardson WD. 2006. Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci 9:173-179.
16. Laird PW, Zijderveld A, Linders K, Rudnicki MA, Jaenisch R, Berns A. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19:4293.
17. Lecca D, Trincavelli ML, Gelosa P, Sironi L, Ciana P, Fumagalli M, Villa G, Verderio C, Grumelli C, Guerrini U, et al. 2008. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One 3:e3579.
18. Maisel M, Herr A, Milosevic J, Hermann A, Habisch HJ, Schwarz S, Kirsch M, Antoniadis G, Brenner R, Hallmeyer-Elgner S, et al. 2007. Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state. Stem Cells 25:1231-1240.
19. Nakamura T, Colbert MC, Robbins J. 2006. Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ Res 98:1547-1554.
20. Psachoulia K, Jamen F, Young KM, Richardson WD. 2009. Cell cycle dynamics of NG2 cells in the postnatal and ageing brain. Neuron Glia Biol 5:57-67.
21. Rivers LE, Young KM, Rizzi M, Jamen F, Psachoulia K, Wade A, Kessaris N, Richardson WD. 2008. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat Neurosci 11:1392-1401.
22. Simon C, Gotz M, Dimou L. 2011. Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury. Glia 59:869-881.
23. Sironi L, Cimino M, Guerrini U, Calvio AM, Lodetti B, Asdente M, Balduini W, Paoletti R, Tremoli E. 2003. Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol 23:322-327.
24. Tomassy GS, Berger DR, Chen HH, Kasthuri N, Hayworth KJ, Vercelli A, Seung HS, Lichtman JW, Arlotta P. 2014. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science 344:319-324.
25. Vigano F, Mobius W, Gotz M, Dimou L. 2013. Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain. Nat Neurosci 16:1370-1372.
26. Wakade C, Khan MM, De Sevilla LM, Zhang QG, Mahesh VB, Brann DW. 2008. Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase. Endocrinology 149:367-379.
27. Young KM, Psachoulia K, Tripathi RB, Dunn SJ, Cossell L, Attwell D, Tohyama K, Richardson WD. 2013. Oligodendrocyte dynamics in the healthy adult CNS: Evidence for myelin remodeling. Neuron 77:873-885.
28. Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C Ruderisch N, et al. 2014. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci 34:11929-11947.
29. Zhu X, Bergles DE, Nishiyama A. 2008. NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 135:145-157.
30. Zhu X, Hill RA, Dietrich D, Komitova M, Suzuki R, Nishiyama A. 2011. Age-dependent fate and lineage restriction of single NG2 cells. Development 138:745-753.