Amphiregulin confers trastuzumab resistance via AKT and ERK activation in HER2-positive breast cancer

Journal of Cancer Research and Clinical Oncology

Volumn 142, Issue 1, 2016, Pages 157-165

  Kim, Ji Won ^a   Kim, Debora K ^b   Min, Ahrum ^c   Lee, Kyung Hun ^c,d   Nam, Hyun Jin ^c   Kim, Jee Hyun ^a   Kim, Jin Soo ^e   Kim, Tae Yong ^c,d   Im, Seock Ah ^c,d   Park, In Ae ^c,d  

^a Seoul National University Bundang Hospital   (South Korea)

^b Seoul International School   (South Korea)

^c Seoul National University   (South Korea)

^d Seoul National University Hospital   (South Korea)

^e Seoul National University Boramae Hospital   (South Korea)

Author keywords

Amphiregulin; Breast cancer; HER2; Resistance; Trastuzumab

Indexed keywords

AMPHIREGULIN; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; TRASTUZUMAB; TUMOR MARKER;

ADULT; AGED; APOPTOSIS; BREAST NEOPLASMS; CANCER STAGING; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; ENZYME IMMUNOASSAY; FEMALE; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; MORTALITY; MUTATION; PATHOLOGY; PROGNOSIS; SURVIVAL RATE; TUMOR CELL CULTURE; WESTERN BLOTTING;

ADULT; AGED; AMPHIREGULIN; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOMARKERS, TUMOR; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MIDDLE AGED; MUTATION; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SURVIVAL RATE; TRASTUZUMAB; TUMOR CELLS, CULTURED;

EID: 84953639772     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-2012-4     Document Type: Article

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