Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans

Geriatrics and Gerontology International

Volumn 16, Issue 1, 2016, Pages 21-27

  Jeong, Su Jin ^a   Han, Sang Hoon ^a   Kim, Chang Oh ^a   Choi, Jun Yong ^a   Song, Young Goo ^a   Kim, June Myung ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Antibody; Cytomegalovirus; Elderly patients; Functional status; Hypertension

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; CYTOMEGALOVIRUS-SPECIFIC HYPERIMMUNE GLOBULIN; IMMUNOGLOBULIN; VIRUS ANTIBODY;

AGE DISTRIBUTION; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DISEASE ASSOCIATION; ESSENTIAL HYPERTENSION; FEMALE; FUNCTIONAL STATUS; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CYTOMEGALOVIRUS; KOREAN (PEOPLE); LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; BLOOD; BODY MASS; CD4 CD8 RATIO; CYTOMEGALOVIRUS; DAILY LIFE ACTIVITY; HEALTH STATUS; HYPERTENSION; IMMUNOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; SOUTH KOREA; VERY ELDERLY; VIROLOGY;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; BODY MASS INDEX; CD4-CD8 RATIO; CYTOMEGALOVIRUS; FEMALE; HEALTH STATUS; HUMANS; HYPERTENSION; IMMUNOGLOBULINS; MALE; PROSPECTIVE STUDIES; REPUBLIC OF KOREA;

EID: 84953637612     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/ggi.12428     Document Type: Article

References (39)

1. Pierdomenico SD, Di Nicola M, Esposito AL etal. Prognostic value of different indices of blood pressure variability in hypertensive patients. Am J Hypertens 2009; 22 (8): 842-847.
2. Lloyd Jones D, Adams R, Carnethon M etal. Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119 (3): 480-486.
3. Stumpf C, John S, Jukic J etal. Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertension. J Hypertens 2005; 23 (5): 995-1000.
4. Kristal B, Shurtz Swirski R, Chezar J etal. Participation of peripheral polymorphonuclear leukocytes in the oxidative stress and inflammation in patients with essential hypertension. Am J Hypertens 1998; 11 (8): 921-928.
5. Crough T, Khanna R. Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev 2009; 22 (1): 76-98, table of contents.
6. Loenen WA, Bruggeman CA, Wiertz EJ. Immune evasion by human cytomegalovirus: lessons in immunology and cell biology. Semin Immunol 2001; 13 (1): 41-49.
7. Streblow DN, Soderberg Naucler C, Vieira J etal. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Cell 1999; 99 (5): 511-520.
8. Dumortier J, Streblow DN, Moses AV etal. Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol 2008; 82 (13): 6524-6535.
9. Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE. Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS ONE 2011; 6 (2): e16103.
10. Grahame-Clarke C, Chan NN, Andrew D etal. Human cytomegalovirus seropositivity is associated with impaired vascular function. Circulation 2003; 108 (6): 678-683.
11. Grahame Clarke C. Human cytomegalovirus, endothelial function and atherosclerosis. Herpes 2005; 12 (2): 42-45.
12. Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? Lancet 1997; 350 (9075): 430-436.
13. Katz S, Downs TD, Cash HR, Grotz RC. Progress in development of the index of ADL. Gerontologist 1970; 10 (1): 20-30.
14. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969; 9 (3): 179-186.
15. Cohen HJ, Harris T, Pieper CF. Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med 2003; 114 (3): 180-187.
16. Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 2000; 55 (12): M709-M715.
17. Ferrucci L, Harris TB, Guralnik JM etal. Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 1999; 47 (6): 639-646.
18. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130 (6): 461-470.
19. Shen YH, Zhang L, Utama B etal. Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10). Cardiovasc Res 2006; 69 (2): 502-511.
20. Wong WT, Wong SL, Tian XY, Huang Y. Endothelial dysfunction: the common consequence in diabetes and hypertension. J Cardiovasc Pharmacol 2010; 55 (4): 300-307.
21. Savoia C, Schiffrin EL. Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions. Clin Sci 2007; 112 (7): 375-384.
22. Wills MR, Carmichael AJ, Mynard K etal. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 1996; 70 (11): 7569-7579.
23. Guzik TJ, Hoch NE, Brown KA etal. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 2007; 204 (10): 2449-2460.
24. Torres OH, Muoz J, Ruiz D etal. Outcome predictors of pneumonia in elderly patients: importance of functional assessment. J Am Geriatr Soc 2004; 52 (10): 1603-1609.
25. Ranieri P, Bianchetti A, Margiotta A, Virgillo A, Clini EM, Trabucchi M. Predictors of 6-month mortality in elderly patients with mild chronic obstructive pulmonary disease discharged from a medical ward after acute nonacidotic exacerbation. J Am Geriatr Soc 2008; 56 (5): 909-913.
26. Aiello AE, Haan M, Blythe L, Moore K, Gonzalez JM, Jagust W. The influence of latent viral infection on rate of cognitive decline over 4 years. J Am Geriatr Soc 2006; 54 (7): 1046-1054.
27. Aiello AE, Haan MN, Pierce CM, Simanek AM, Liang J. Persistent infection, inflammation, and functional impairment in older Latinos. J Gerontol A Biol Sci Med Sci 2008; 63 (6): 610-618.
28. Payne GW. Effect of inflammation on the aging microcirculation: impact on skeletal muscle blood flow control. Microcirculation 2006; 13 (4): 343-352.
29. Schaap LA, Pluijm SM, Deeg DJ etal. Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci 2009; 64 (11): 1183-1189.
30. Cheng J, Ke Q, Jin Z etal. Cytomegalovirus infection causes an increase of arterial blood pressure. PLoS Pathog 2009; 5 (5): e1000427-e1000427.
31. Speir E, Yu ZX, Ferrans VJ, Huang ES, Epstein SE. Aspirin attenuates cytomegalovirus infectivity and gene expression mediated by cyclooxygenase-2 in coronary artery smooth muscle cells. Circ Res 1998; 83 (2): 210-216.
32. Kowalik TF, Wing B, Haskill JS, Azizkhan JC, Baldwin AS, Huang ES. Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection. Proc Natl Acad Sci U S A 1993; 90 (3): 1107-1111.
33. Geist LJ, Monick MM, Stinski MF, Hunninghake GW. The immediate early genes of human cytomegalovirus upregulate expression of the interleukin-2 and interleukin-2 receptor genes. Am J Respir Cell Mol Biol 1991; 5 (3): 292-296.
34. Alcami J, Barzu T, Michelson S. Induction of an endothelial cell growth factor by human cytomegalovirus infection of fibroblasts. J Gen Virol 1991; 72 (11): 2765-2770.
35. O'Brien KD, Allen MD, McDonald TO etal. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest 1993; 92 (2): 945-951.
36. Span AH, van Dam-Mieras MC, Mullers W, Endert J, Muller AD, Bruggeman CA. The effect of virus infection on the adherence of leukocytes or platelets to endothelial cells. Eur J Clin Invest 1991; 21 (3): 331-338.
37. van Dam-Mieras MC, Muller AD, van Hinsbergh VW, Mullers WJ, Bomans PH, Bruggeman CA. The procoagulant response of cytomegalovirus infected endothelial cells. Thromb Haemost 1992; 68 (3): 364-370.
38. Kuo H, Yu Y. The relation of peripheral arterial disease to leg force, gait speed, and functional dependence among older adults. J Gerontol A Biol Sci Med Sci 2008; 63 (4): 384-390.
39. McDermott MM, Liu K, Greenland P etal. Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms. JAMA 2004; 292 (4): 453-461.