Relationship of plasma cell-free DNA level with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever

Journal of Medical Virology

Volumn 88, Issue 7, 2016, Pages 1152-1158

  Bakir, Mehmet ^a   Engin, Aynur ^a   Kuskucu, Mert Ahmet ^b   Bakir, Sevtap ^a   Gündag, Omür ^a   Midilli, Kenan ^b  

^a CUMHURIYET UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Cell free DNA; Crimean Congo hemorrhagic fever; Mortality; Prognosis

Indexed keywords

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CRIMEAN CONGO HEMORRHAGIC FEVER; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE DURATION; FEMALE; GENE SEQUENCE; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PLASMA CELL; PREDICTIVE VALUE; PROGNOSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SURVIVOR; VIRUS LOAD; AGED; BLOOD; GENETICS; ISOLATION AND PURIFICATION; MIDDLE AGED; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX; VIROLOGY;

BIOLOGICAL MARKER; VIRUS DNA;

ADULT; AGED; BIOMARKERS; CONVALESCENCE; DNA, VIRAL; FEMALE; HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO; HEMORRHAGIC FEVER, CRIMEAN; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; ROC CURVE; SEVERITY OF ILLNESS INDEX; VIRAL LOAD;

EID: 84953449788     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.24446     Document Type: Article

References (35)

1. Akinci E, Bodur H, Leblebicioglu H. 2013. Pathogenesis of Crimean-Congo hemorrhagic Fever. Vector Borne Zoonotic Dis 13:429-437.
2. Antonatos D, Patsilinakos S, Spanodimos S, Korkonikitas P, Tsigas D. 2006. Cell-free DNA levels as a prognostic marker in acute myocardial infarction. Ann N Y Acad Sci 1075:278-281.
3. Ardalan MR, Tubbs RS, Chinikar S, Shoja MM. 2006. Crimean-Congo haemorrhagic fever presenting as thrombotic microangiopathy and acute renal failure. Nephrol Dial Transplant 21:2304-2307.
4. Bakir M, Gözel MG, Köksal I, Aşik Z, Günal O, Yilmaz H, But A, Yilmaz G, Engin A. 2015. Validation of a severity grading score (SGS) system for predicting the course of disease and mortality in patients with Crimean-Congo hemorrhagic fever (CCHF). Eur J Clin Microbiol Infect Dis 34:325-330.
5. Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. 2013. Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome, and genetic diversity. Antiviral Res 100:159-189.
6. Biçakçi Z, Tavil B, Tezer H, Olcay L. 2013. Hemophagocytosis in a case with Crimean-Congo hemorrhagic fever and an overview of possible pathogenesis with current evidence. Turk J Pediatr 55:344-348.
7. Burt FJ, Swanepoel R, Shieh WJ, Smith JF, Leman PA, Greer PW, Coffield LM, Rollin PE, Ksiazek TG, Peters CJ, Zaki SR. 1997. Immunohistochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. Arch Pathol Lab Med 121:839-846.
8. Butt AN, Swaminathan R. 2008. Overview of circulating nucleic acids in plasma/serum. Ann N Y Acad Sci 1137:236-242.
9. Cagatay A, Kapmaz M, Karadeniz A, Basaran S, Yenerel M, Yavuz S, Midilli K, Ozsut H, Eraksoy H, Calangu S. 2007. Haemophagocytosis in a patient with Crimean-Congo haemorrhagic fever. J Med Microbiol 56:1126-1128.
10. Fraisier C, Rodrigues R, Vu Hai V, Belghazi M, Bourdon S, Paranhos-Baccala G, Camoin L, Almeras L, Peyrefitte CN. 2014. Hepatocyte pathway alterations in response to in vitro Crimean-Congo hemorrhagic fever virus infection. Virus Res 179:187203.
11. Ha TT, Huy NT, Murao LA, Lan NT, Thuy TT, Tuan HM, Nga CT, Tuong VV, Dat TV, Kikuchi M, Yasunami M, Morita K, Huong VT, Hirayama K. 2011. Elevated levels of cell-free circulating DNA in patients with acute dengue virus infection. PLoS ONE 6:e25969.
12. Huttunen R, Kuparinen T, Jylhävä J, Aittoniemi J, Vuento R, Huhtala H, Laine J, Syrjänen J, Hurme M. 2011. Fatal outcome in bacteremia is characterized by high plasma cell free DNA concentration and apoptotic DNA fragmentation: A prospective cohort study. PLoS ONE 6:e21700.
13. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R. 2001. DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61:1659-1665.
14. Jylhävä J, Kotipelto T, Raitala A, Jylhä M, Hervonen A, Hurme M. 2011. Aging isassociated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ study. Mech Ageing Dev 132:20-26.
15. Karlberg H, Tan YJ, Mirazimi A. 2011. Induction of caspase activation and cleavage of the viral nucleocapsid protein in different cell types during Crimean-Congo hemorrhagic fever virus infection. J Biol Chem 286:3227-3234.
16. Karti SS, Odabasi Z, Korten V, Yilmaz M, Sonmez M, Caylan R, Akdogan E, Eren N, Koksal I, Ovali E, Erickson BR, Vincent MJ, Nichol ST, Comer JA, Rollin PE, Ksiazek TG. 2004. Crimean-Congo hemorrhagic fever in Turkey. Emerg Infect Dis 10:1379-1384.
17. Lo YM, Rainer TH, Chan LY, Hjelm NM, Cocks RA. 2000. Plasma DNA as a prognostic marker in trauma patients. Clin Chem 46:319-323.
18. Moreira VG, Prieto B, Rodriguez JSM, Alvarez FV. 2010. Usefulness of cell-free plasma DNA, procalcitonin and C-reactive protein as markers of infection in febrile patients. Ann Clin Biochem 47:253-258.
19. Mosca M, Giuliano T, Cuomo G, Doveri M, Tani C, Curcio M, Abignano G, De Feo F, Bazzichi L, Della Rossa A, Valentini G, Bombardieri S. 2009. Cell-free DNA in the plasma of patients with systemic sclerosis. Clin Rheumatol 28:1437-1440.
20. Mustonen J, Mäkelä S, Outinen T, Laine O, Jylhävä J, Arstila PT, Hurme M, Vaheri A. 2013. The pathogenesis of nephropathia epidemica: New knowledge and unanswered questions. Antiviral Res 100:589-604.
21. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. 2013. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: Derivation and validation. PLoS Med 10:e1001577.
22. Outinen TK, Kuparinen T, Jylhävä J, Leppänen S, Mustonen J, Mäkelä S, Pörsti I, Syrjänen J, Vaheri A, Hurme M. 2012. Plasma cell-free DNA levels are elevated in acute Puumala hantavirus infection. PLoS ONE 7:e31455.
23. Rainer TH, Wong LK, Lam W, Yuen E, Lam NY, Metreweli C, Lo YM. 2003. Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin Chem 49:562-569.
24. Rhodes A, Wort SJ, Thomas H, Collinson P, Bennett ED. 2006. Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients. Crit Care 10:R60.
25. Rodrigues R, Paranhos-Baccalà G, Vernet G, Peyrefitte CN. 2012. Crimean-Congo hemorrhagic fever virus-infected hepatocytes induce ER-stress and apoptosis crosstalk. PLoS ONE 7:e29712.
26. Saukkonen K, Lakkisto P, Varpula M, Varpula T, VoipioPulkki LM, Pettilä V, Pulkki K. 2007. Association of cell-free plasma DNAwith hospital mortality and organ dysfunctionin intensive care unit patients. Intensive Care Med 33:1624-1627.
27. Saukkonen K, Lakkisto P, Pettilä V, Varpula M, Karlsson S, Ruokonen E, Pulkki K. Finnsepsis Study Group. 2008. Cell-free plasma DNA as a predictor of outcome in severe sepsis and septic shock. Clin Chem 54:1000-1007.
28. Tasdelen Fisgin N, Fisgin T, Tanyel E, Doganci L, Tulek N, Guler N, Duru F. 2008. Crimean-Congo hemorrhagic fever: Five patients with hemophagocytic syndrome. Am J Hematol 83:73-76.
29. Whitehouse CA. 2004. Crimean-Congo hemorrhagic fever. Antiviral Res 64:145-160.
30. Wijeratne S, Butt A, Burns S, Sherwood K, Boyd O, Swaminathan R. 2004. Cell-free plasma DNA as a prognostic marker in intensive treatment unit patients. Ann NY Acad Sci 1022:232-238.
31. Yi J, Zhang Y, Zhang Y, Ma Y, Zhang C, Li Q, Liu B, Liu Z, Liu J, Zhang X, Zhuang R, Jin B. 2014. Increased plasma cell-free DNA level during HTNV infection: Correlation with disease severity and virus load. Viruses 6:2723-2734.
32. Yilmaz M, Aydin K, Akdogan E, Sucu N, Sonmez M, Omay SB, Koksal I. 2008. Peripheral blood natural killer cells in Crimean-Congo hemorrhagic fever. J Clin Virol 42:415-417.
33. Yoon KA, Park S, Lee SH, Kim JH, Lee JS. 2009. Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls. J Mol Diagn 11:182-185.
34. Zhong XY, von Mühlenen I, Li Y, Kang A, Gupta AK, Tyndall A, Holzgreve W, Hahn S, Hasler P. 2007a. Increased concentrations of antibody-bound circulatory cell-free DNA in rheumatoid arthritis. Clin Chem 53:1609-1614.
35. Zhong XY, Hahn S, Kiefer V, Holzgreve W. 2007b. Is the quantity of circulatorycell-free DNA in human plasma and serum samples associated with gender, age, and frequency of blood donations? Ann Hematol 86:139-143.