Low E-prostanoid 2 receptor levels and deficient induction of the IL-1β/IL-1 type i receptor/COX-2 pathway: Vicious circle in patients with aspirin-exacerbated respiratory disease

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 1, 2016, Pages 99-107.e7

  Machado Carvalho, Liliana ^a,b   Martín, Margarita ^a,c   Torres, Rosa ^a,b,d   Gabasa, Marta ^a,b   Alobid, Isam ^a,b,e   Mullol, Joaquim ^a,b,e   Pujols, Laura ^a,b   Roca Ferrer, Jordi ^a,b   Picado, Cesar ^a,b,c  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e HOSPITAL CLÍNIC   (Spain)

Author keywords

Aspirin exacerbated respiratory disease; COX 2; E prostanoid 2 receptor; fibroblasts; IL 1 receptor type I; IL 1 ; microsomal prostaglandin E synthase 1; nasal mucosa; nasal polyps; prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; ACETYLSALICYLIC ACID; BUTAPROST; ISOMERASE; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E1; PTGS2 PROTEIN, HUMAN;

ARTICLE; ASPIRIN EXACERBATED RESPIRATORY DISEASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; LUNG FIBROBLAST; NOSE MUCOSA; NOSE POLYP; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ADULT; AGED; AGONISTS; ANALOGS AND DERIVATIVES; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FEMALE; FIBROBLAST; GENETICS; MALE; METABOLISM; MIDDLE AGED;

ADULT; AGED; ALPROSTADIL; ASPIRIN; ASTHMA, ASPIRIN-INDUCED; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; FIBROBLASTS; HUMANS; INTERLEUKIN-1BETA; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MIDDLE AGED; NASAL MUCOSA; NASAL POLYPS; RECEPTORS, INTERLEUKIN-1 TYPE I; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RNA, MESSENGER;

EID: 84953410419     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.09.028     Document Type: Article

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