Prospective clinical and serological follow-up in early childhood reveals a high rate of subclinical RSV infection and a relatively high reinfection rate within the first 3 years of life

Epidemiology and Infection

Volumn 144, Issue 8, 2016, Pages 1622-1633

  Kutsaya, A ^a   Teros Jaakkola, T ^a,b   Kakkola, L ^a   Toivonen, L ^a,b   Peltola, V ^a,b   Waris, M ^a   Julkunen, I ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Antibodies; infants; reinfection; RSV; seroprevalence

Indexed keywords

RESPIRATORY SYNCYTIAL VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS RNA; VIRUS ANTIBODY;

ARTICLE; BLOOD SAMPLING; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; REINFECTION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SEROLOGY; SEROPREVALENCE; SERUM; ASYMPTOMATIC INFECTIONS; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; INFANT; MALE; PRESCHOOL CHILD; RECURRENT DISEASE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; SEROEPIDEMIOLOGY;

ANTIBODIES, VIRAL; ASYMPTOMATIC INFECTIONS; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; PROSPECTIVE STUDIES; RECURRENCE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROEPIDEMIOLOGIC STUDIES;

EID: 84953226726     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268815003143     Document Type: Article

References (28)

1. Nair H, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-Analysis. Lancet 2010; 375: 1545-1555
2. Berkley JA, et al. Viral etiology of severe pneumonia among Kenyan infants and children. Journal of the American Medical Association 2010; 303: 2051-2057
3. Hall CB, et al. The burden of respiratory syncytial virus infection in young children. New England Journal of Medicine 2009; 360: 588-598
4. Ohuma EO, et al. The natural history of respiratory syncytial virus in a birth cohort: the influence of age and previous infection on reinfection and disease. American Journal of Epidemiology 2012; 176: 794-802
5. Glezen WP, et al. Risk of primary infection and reinfection with respiratory syncytial virus. American Journal of Diseases of Children 1986; 140: 543-546
6. Henderson FW, et al. Respiratory-syncytial-virus infections, reinfections and immunity. A prospective, longitudinal study in young children. New England Journal of Medicine 1979; 300: 530-534
7. Hall CB, et al. Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. Journal of Infectious Diseases 1990; 162: 1283-1290
8. Waris M. Pattern of respiratory syncytial virus epidemics in Finland: two-year cycles with alternating prevalence of groups A and B. Journal of Infectious Diseases 1991; 163: 464-469
9. White LJ, et al. The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England &Wales and Finland: seasonality and cross-protection. Epidemiology and Infection 2005; 133: 279-289
10. Domachowske JB, Rosenberg HF. Respiratory syncytial virus infection: immune response, immunopathogenesis, and treatment. Clinical Microbiology Reviews 1999; 12: 298-309
11. Roca A, et al. Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique. Journal of Medical Virology 2002; 67: 616-623
12. Englund JA, Piedra PA, Whimbey E. Prevention and treatment of respiratory syncytial virus and parainfluenza viruses in immunocompromised patients. American Journal of Medicine 1997; 102: 61-70; discussion 75-6
13. Zambon M. Active and passive immunisation against respiratory syncytial virus. Reviews in Medical Virology 1999; 9: 227-236
14. Lagstrom H, et al. Cohort profile: Steps to the healthy development and well-being of children (the STEPS Study). International Journal of Epidemiology 2013; 42: 1273-1284
15. Meurman O, Waris M, Hedman K. Immunoglobulin G antibody avidity in patients with respiratory syncytial virus infection. Journal of Clinical Microbiology 1992; 30: 1479-1484
16. Osterback R, et al. Simultaneous detection and differentiation of human rhino-And enteroviruses in clinical specimens by real-Time PCR with locked nucleic acid probes. Journal of Clinical Microbiology 2013; 51: 3960-3967
17. Toivonen L, et al. Blood MxA protein as a marker for respiratory virus infections in young children. Journal of Clinical Virology 2015; 62: 8-13
18. Hu A, et al. Simultaneous detection, subgrouping, and quantitation of respiratory syncytial virus A and B by real-Time PCR. Journal of Clinical Microbiology 2003; 41: 149-154
19. Groothuis JR, et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group. New England Journal of Medicine 1993; 329: 1524-1530
20. Ochola R, et al. The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya. PLoS ONE 2009; 4: e8088
21. Brandenburg AH, et al. Respiratory syncytial virus specific serum antibodies in infants under six months of age: limited serological response upon infection. Journal of Medical Virology 1997; 52: 97-104
22. Welliver RC, et al. The antibody response to primary and secondary infection with respiratory syncytial virus: kinetics of class-specific responses. Journal of Pediatrics 1980; 96: 808-813
23. Walsh EE, Falsey AR. Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults. Journal of Infectious Diseases 2004; 190: 373-378
24. Falsey AR, Singh HK, Walsh EE. Serum antibody decay in adults following natural respiratory syncytial virus infection. Journal of Medical Virology 2006; 78: 1493-1497
25. Sande CJ, et al. Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort. Journal of Medical Virology 2013; 85: 2020-2025
26. Pothier P, et al. Antigenic variations of respiratory syncytial virus in recurrent infections. European Journal of Clinical Microbiology 1987; 6: 212
27. Walsh EE, et al. Severity of respiratory syncytial virus infection is related to virus strain. Journal of Infectious Diseases 1997; 175: 814-820
28. Hierholzer JC, et al. Subgrouping of respiratory syncytial virus strains from Australia and Papua New Guinea by biological and antigenic characteristics. Archives of Virology 1994; 136: 133-147