메뉴 건너뛰기




Volumn , Issue , 2006, Pages 1-13

Pharmacophores: Historical Perspective and Viewpoint from a Medicinal Chemist

Author keywords

Concept of receptors; Functional groups; Historical perspective; Pharmacophore searches; Pharmacophores; Structure activity relationships; Three dimensional approach; Two dimensional pharmacophores; Viewpoint of a medicinal chemist

Indexed keywords

FUNCTIONAL GROUPS;

EID: 84952896774     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/3527609164.ch1     Document Type: Chapter
Times cited : (37)

References (39)
  • 1
    • 0001008140 scopus 로고    scopus 로고
    • Glossary of terms used in medicinal chemistry (IU- PAC Recommendations 1997)
    • Wermuth, C.G., Ganellin, C.R., Lind- berg, P., Mitscher, L.A., Glossary of terms used in medicinal chemistry (IU- PAC Recommendations 1997). Annu. Rep. Med. Chem. 1998, 33, 385-395.
    • (1998) Annu. Rep. Med. Chem , vol.33 , pp. 385-395
    • Wermuth, C.G.1    Ganellin, C.R.2    Lind-berg, P.3    Mitscher, L.A.4
  • 3
    • 0000625831 scopus 로고    scopus 로고
    • Privileged structures-an update
    • Trainor, G., Privileged structures-an update. Annu.Rep. Med. Chem. 2000, 35, 289-298.
    • (2000) Annu.Rep. Med. Chem , vol.35 , pp. 289-298
    • Trainor, G.1
  • 4
    • 0000446756 scopus 로고    scopus 로고
    • A method for visualizing recurrent topological sub- structures in sets of active molecules
    • Sheridan, R.P., Miller, M.D., A method for visualizing recurrent topological sub- structures in sets of active molecules. J. Chem. Inf. Comput. Sci. 1998, 38, 915-924.
    • (1998) J. Chem. Inf. Comput. Sci , vol.38 , pp. 915-924
    • Sheridan, R.P.1    Miller, M.D.2
  • 5
    • 7044263277 scopus 로고
    • Synthesis and applications of small molecule li- braries
    • Thompson, L.A., Ellman, J.A., Synthesis and applications of small molecule li- braries. Chem. Rev. 1966, 96, 555-600.
    • (1966) Chem. Rev , vol.96 , pp. 555-600
    • Thompson, L.A.1    Ellman, J.A.2
  • 6
    • 0031737819 scopus 로고    scopus 로고
    • Search for new lead compounds: the example of the chemical and pharmacological dissection of ami- nopyridazines
    • Wermuth, C.G., Search for new lead compounds: the example of the chemical and pharmacological dissection of ami- nopyridazines. J. Heterocycl. Chem., 1998, 35, 1091-1100.
    • (1998) J. Heterocycl. Chem , vol.35 , pp. 1091-1100
    • Wermuth, C.G.1
  • 7
    • 0034618541 scopus 로고    scopus 로고
    • Privileged molecules for protein binding identified from NMR- based screening
    • Hajduk, P. J., Bures, M., Praestgaard, J., Fesik, S.W., Privileged molecules for protein binding identified from NMR- based screening. J. Med. Chem. 2000, 43, 3443-3447.
    • (2000) J. Med. Chem , vol.43 , pp. 3443-3447
    • Hajduk, P.J.1    Bures, M.2    Praestgaard, J.3    Fesik, S.W.4
  • 9
    • 0002068416 scopus 로고
    • Early theories of the mode of action of drugs and poisons
    • (publ. 1963)
    • Earles, M.P., Early theories of the mode of action of drugs and poisons. Ann. Sci. 1961 (publ. 1963), 17, 97-110.
    • (1961) Ann. Sci. , vol.17 , pp. 97-110
    • Earles, M.P1
  • 12
    • 84943213189 scopus 로고
    • The pharmacologic action of drugs: is it determined by chemical structure or by physical characters?
    • Cushny, A.R., The pharmacologic action of drugs: is it determined by chemical structure or by physical characters? J. Am. Med. Assoc. 1903, 41, 1252-1253.
    • (1903) J. Am. Med. Assoc , vol.41 , pp. 1252-1253
    • Cushny, A.R.1
  • 13
    • 84942186665 scopus 로고
    • On the physiology of the salivary secretion. Part II. On the mutual antagonism of atropin and pilocarpin, having especial reference to their rela- tions in the sub-maxillary gland of the cat
    • Langley, J.N., On the physiology of the salivary secretion. Part II. On the mutual antagonism of atropin and pilocarpin, having especial reference to their rela- tions in the sub-maxillary gland of the cat. J. Physiol. 1878, 1, 339-369.
    • (1878) J. Physiol , vol.1 , pp. 339-369
    • Langley, J.N.1
  • 14
    • 28244486354 scopus 로고
    • On the reaction of cells and nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari
    • Langley, J.N., On the reaction of cells and nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J. Phys- iol. 1905, 33, 374-413.
    • (1905) J. Phys- iol , vol.33 , pp. 374-413
    • Langley, J.N.1
  • 15
    • 0001595788 scopus 로고
    • über Hae- molysine. Dritte Mitteilung
    • Ehrlich, P., Morgenroth, J., über Hae- molysine. Dritte Mitteilung. Berl. Klin. Wochnschr. 1900, 37, 453-457.
    • (1900) Berl. Klin. Wochnschr , vol.37 , pp. 453-457
    • Ehrlich, P.1    Morgenroth, J.2
  • 18
    • 84892166712 scopus 로고
    • Einfluss der Konfiguration auf die Wirkung der Enzyme
    • Fischer, E., Einfluss der Konfiguration auf die Wirkung der Enzyme. Ber. Dtsch. Chem. Ges. 1894, 27, 2985-2993.
    • (1894) Ber. Dtsch. Chem. Ges , vol.27 , pp. 2985-2993
    • Fischer, E.1
  • 19
    • 0002009389 scopus 로고
    • The relation of p-amino- benzoic acid to the mechanism of the ac- tion of sulphonamide
    • Woods, D.D., The relation of p-amino- benzoic acid to the mechanism of the ac- tion of sulphonamide. Br. J. Exp. Pathol. 1940, 21, 74-90.
    • (1940) Br. J. Exp. Pathol , vol.21 , pp. 74-90
    • Woods, D.D.1
  • 20
    • 33751539405 scopus 로고
    • The anti-sulpha- nilamide activity (in vitro)of p-aminoben- zoic acid and related compounds
    • Woods, D.D., Fildes, P., The anti-sulpha- nilamide activity (in vitro)of p-aminoben- zoic acid and related compounds. Chem. Ind. 1940, 59, 133-134.
    • (1940) Chem. Ind , vol.59 , pp. 133-134
    • Woods, D.D.1    Fildes, P.2
  • 21
    • 0000255698 scopus 로고
    • Molecular structure in relation to oestrogenic activ- ity. Compounds without phenanthrene nucleus
    • Dodds, E.C., Lawson, W., Molecular structure in relation to oestrogenic activ- ity. Compounds without phenanthrene nucleus. Proc. R. Soc. London, Ser. B 1938, 125, 122-132.
    • (1938) Proc. R. Soc. London, Ser. B , vol.125 , pp. 122-132
    • Dodds, E.C.1    Lawson, W.2
  • 22
    • 0141452506 scopus 로고
    • Sex hormonal action and chemical constitution
    • Schueler, F.W., Sex hormonal action and chemical constitution. Science 1946, 103, 221-223.
    • (1946) Science , vol.103 , pp. 221-223
    • Schueler, F.W1
  • 23
    • 0000165020 scopus 로고
    • Studies on the relationship between chemical con- stitution and physiological action. V. Mo- lecular dissymmetry and physiological activity
    • Easson, L.H., Stedman, E., Studies on the relationship between chemical con- stitution and physiological action. V. Mo- lecular dissymmetry and physiological activity. Biochem. J. 1933, 27, 1257-1266.
    • (1933) Biochem. J , vol.27 , pp. 1257-1266
    • Easson, L.H.1    Stedman, E.2
  • 24
    • 0000412915 scopus 로고
    • Stereochemical factors in biological activity
    • Birkhäuser Verlag, Basel
    • Beckett, A.H., Stereochemical factors in biological activity. In Fortschritte der Arz- neimittel Forschung, Birkhäuser Verlag, Basel, 1959, pp. 455-530.
    • (1959) In Fortschritte der Arz- neimittel Forschung , pp. 455-530
    • Beckett, A.H1
  • 25
    • 0002929747 scopus 로고
    • Speculations on the design of nonpeptide peptidomi- metics
    • Farmer, P.S., Ariëns, E. J., Speculations on the design of nonpeptide peptidomi- metics. Trends Pharmacol. Sci. 1982, 3, 362-365.
    • (1982) Trends Pharmacol. Sci , vol.3 , pp. 362-365
    • Farmer, P.S.1    Ariëns, E.J.2
  • 29
    • 0015251123 scopus 로고
    • Quantum mechanical study of the conformational properties of phenethylamines of biochemical and medicinal interest
    • Pullmann, B., Coubeils, J.L., Courrière, P., Gervois, J.P., Quantum mechanical study of the conformational properties of phenethylamines of biochemical and medicinal interest. J. Med. Chem. 1972, 15, 17-23.
    • (1972) J. Med. Chem , vol.15 , pp. 17-23
    • Pullmann, B.1    Coubeils, J.L.2    Courrière, P.3    Gervois, J.P.4
  • 30
    • 0005997556 scopus 로고
    • Conformation de la clonidine et hypothèses sur son inter- action avec un récepteur alpha-adrénergi- que
    • Wermuth, C.G., Schwartz, J., Leclerc, G., Garnier, J.P., Rouot, B., Conformation de la clonidine et hypothèses sur son inter- action avec un récepteur alpha-adrénergi- que. Chim. Thér. 1973, 1, 115-116.
    • (1973) Chim. Thér , vol.1 , pp. 115-116
    • Wermuth, C.G.1    Schwartz, J.2    Leclerc, G.3    Garnier, J.P.4    Rouot, B.5
  • 33
    • 0004866509 scopus 로고    scopus 로고
    • The impact of QSAR and CADD methods in drug design
    • Hoeltje, H.D., Sippl, W. (eds.). Prous Science, Barcelona
    • Wermuth, C.G., The impact of QSAR and CADD methods in drug design. In Rational Approaches to Drug Design, Hoeltje, H.D., Sippl, W. (eds.). Prous Science, Barcelona, 2001, pp. 3-20.
    • (2001) In Rational Approaches to Drug Design , pp. 3-20
    • Wermuth, C.G.1
  • 34
    • 0033523672 scopus 로고    scopus 로고
    • "Scaffold-hopping" by topo- logical pharmacophore search: a contri- bution to virtual screening
    • Schneider, G., Giller, T., Neidhart, W., Schmid, G., "Scaffold-hopping" by topo- logical pharmacophore search: a contri- bution to virtual screening. Angew. Chem. Int. Ed. 1999, 38, 2894-2896.
    • (1999) Angew. Chem. Int. Ed , vol.38 , pp. 2894-2896
    • Schneider, G.1    Giller, T.2    Neidhart, W.3    Schmid, G.4
  • 36
    • 0001874067 scopus 로고
    • The pharmacon-recep- tor-effector concept: a basis for under- standing the transmission of informa- tion in biological systems
    • O'Brien, R.D. (ed.). Plenum Press, New York
    • Ariëns, E. J., Rodrigues de Miranda, J.F., Simonis, A.M., The pharmacon-recep- tor-effector concept: a basis for under- standing the transmission of informa- tion in biological systems. In The Recep- tors, O'Brien, R.D. (ed.). Plenum Press, New York, 1979, pp. 33-91.
    • (1979) In The Recep- tors , pp. 33-91
    • Ariëns, E.J.1    Rodrigues de Miranda, J.F.2    Simonis, A.M3
  • 37
    • 0027273657 scopus 로고
    • Aminopyridazines-an alternative route to potent muscarinic agonists with no cholinergic syndrome
    • Wermuth, C.G., Aminopyridazines-an alternative route to potent muscarinic agonists with no cholinergic syndrome. Farmaco 1993, 48, 253-274.
    • (1993) Farmaco , vol.48 , pp. 253-274
    • Wermuth, C.G.1
  • 39
    • 3242794178 scopus 로고    scopus 로고
    • From magic bullets to designed multiple ligands
    • Morphy, R., Kay, C., Rankovic, Z., From magic bullets to designed multiple ligands. Drug Discov. Today 2004, 9, 641- 651.
    • (2004) Drug Discov. Today , vol.9 , pp. 641- 651
    • Morphy, R.1    Kay, C.2    Rankovic, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.