Hepatic Dysfunction as a Complication of Combined Valproate and Ketogenic Diet

Pediatric Neurology

Volumn 54, Issue , 2016, Pages 82-84

  Stevens, Clare E ^a   Turner, Zahava ^a   Kossoff, Eric H ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

complications; epilepsy; hepatitis; ketosis; liver; side effects; valproic acid

Indexed keywords

AMMONIA; AMOXICILLIN PLUS CLAVULANIC ACID; AMYLASE; CARBON DIOXIDE; CLOBAZAM; CORTICOTROPIN; CREATININE; ETIRACETAM; GLUCOSE; HEMOGLOBIN; PROTEIN HYDROLYSATE; TOPIRAMATE; TRIACYLGLYCEROL LIPASE; VALPROIC ACID; ANTICONVULSIVE AGENT;

ABSENCE; AMMONIA BLOOD LEVEL; AMYLASE BLOOD LEVEL; ARTICLE; CASE REPORT; CHILD; CREATININE BLOOD LEVEL; CYANOSIS; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; HYPSARRHYTHMIA; INFANTILE SPASM; KETOGENIC DIET; LENNOX GASTAUT SYNDROME; LETHARGY; LEUKOCYTE COUNT; LIVER DYSFUNCTION; MUSCLE HYPOTONIA; NOSE OBSTRUCTION; NOSE SMEAR; PARAMYXOVIRINAE; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; QUALITY OF LIFE; RHINORRHEA; THORAX RADIOGRAPHY; THROMBOCYTE COUNT; TONIC CLONIC SEIZURE; TREATMENT OUTCOME; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; ADVERSE EFFECTS; DRUG RESISTANT EPILEPSY; ENZYMOLOGY; FOLLOW UP; INFANT; LIVER DISEASES; MULTIMODALITY CANCER THERAPY; RETREATMENT;

ANTICONVULSANTS; COMBINED MODALITY THERAPY; DRUG RESISTANT EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; KETOGENIC DIET; LENNOX GASTAUT SYNDROME; LIVER DISEASES; RETREATMENT; TREATMENT OUTCOME; VALPROIC ACID;

EID: 84952837980     PISSN: 08878994     EISSN: 18735150     Source Type: Journal    
DOI: 10.1016/j.pediatrneurol.2015.10.006     Document Type: Article

References (11)

1. R.M. Wilder The effects of ketonemia on the course of epilepsy Mayo Clin Proc 2 1921 307 308
2. D.L. Keene A systematic review of the use of the ketogenic diet in childhood epilepsy Pediatr Neurol 35 2006 1 5
3. H.C. Kang, D.E. Chung, D.W. Kim, and H.D. Kim Early- and late-onset complications of the ketogenic diet for intractable epilepsy Epilepsia 45 2004 1116 1123
4. K. Ballaban-Gil, C. Callahan, C. O'Dell, M. Pappo, S. Moshé, and S. Shinnar Complications of the ketogenic diet Epilepsia 39 1998 744 748
5. I.M. Bank, S.D. Shemie, B. Rosenblatt, C. Bernard, and A.S. Mackie Sudden cardiac death in association with the ketogenic diet Pediatr Neurol 39 2008 429 431
6. E. Björnsson Hepatotoxicity associated with antiepileptic drugs Acta Neurol Scand 118 2008 281 290
7. M. Kverneland, E. Tauboll, K.K. Selmer, P.O. Iversen, and K.O. Nakken Modified Atkins diet may reduce serum concentrations of antiepileptic drugs Acta Neurol Scand 131 2015 187 190
8. M.G. Dahlin, O.M. Beck, and P.E. Amark Plasma levels of antiepileptic drugs in children on the ketogenic diet Pediatr Neurol 35 2006 6 10
9. P.B. Mortensen Inhibition of fatty acid oxidation by valproate Lancet 2 1980 856 857
10. D.L. Coulter Carnitine deficiency in epilepsy: Risk factors and treatment J Child Neurol 10 Suppl 2 1995 S32 S39
11. E. Berry-Kravis, G. Booth, A.C. Sanchez, and J. Woodbury-Kolb Carnitine levels and the ketogenic diet Epilepsia 42 2001 1445 1451