Cardiac Arrest and Seizures Caused by Local Anesthetic Systemic Toxicity after Peripheral Nerve Blocks: Should We Still Fear the Reaper?

Regional Anesthesia and Pain Medicine

Volumn 41, Issue 1, 2016, Pages 5-21

  Liu, Spencer S ^a,b   Ortolan, Sarah ^a   Sandoval, Miguel Vizarreta ^a   Curren, Jodie ^a   Fields, Kara G ^a   Memtsoudis, Stavros G ^a,b   YaDeau, Jacques T ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BUPIVACAINE; LOCAL ANESTHETIC AGENT; MEPIVACAINE;

AGED; ARTICLE; BRAIN DAMAGE; DEATH; EPIDURAL ANESTHESIA; FEMALE; HEART ARREST; HUMAN; INCIDENCE; LOCAL ANESTHETIC SYSTEMIC TOXICITY; MAJOR CLINICAL STUDY; MALE; NERVE BLOCK; PERIPHERAL NERVE BLOCK; PEROPERATIVE COMPLICATION; PRIORITY JOURNAL; REGIONAL ANESTHESIA; RETROSPECTIVE STUDY; RISK ASSESSMENT; SEIZURE; ADULT; ADVERSE EFFECTS; CHEMICALLY INDUCED; FEAR; MIDDLE AGED; SEIZURES; TRENDS;

ADULT; AGED; ANESTHETICS, LOCAL; AUTONOMIC NERVE BLOCK; FEAR; FEMALE; HEART ARREST; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEIZURES;

EID: 84952332542     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0000000000000329     Document Type: Article

References (20)

1. Paul JE, Arya A, Hurlburt L, et al. Femoral nerve block improves analgesia outcomes after total knee arthroplasty: a meta-Analysis of randomized controlled trials. Anesthesiology. 2010;113:1114-1162.
2. Sites BD, Ch an VW, Neal JM, et al. The American Society of Regional Anesthesia and Pain Medicine and the European Society of Regional Anaesthesia and Pain Therapy joint committee recommendations for education and training in ultrasound-guided regional an esthesia. Reg Anesth Pain Med. 2010;35(suppl 2):S74-S80.
3. Neal JM, Liguori GA, Hargett MJ. The training and careers of regional anesthesiology and acute pain medicine fellows, 2013. Reg Anesth Pain Med. 2015;40:218-222.
4. Auroy Y, Benhamou D, Bargues L, et al. Major complications of regional anesthesia in France: the SOS Regional Anesthesia Hotline Service. Anesthesiology. 2002;97:1274-1280.
5. Lee LA, Posner KL, Cheney FW, Caplan RA, Domino KB. Complications associated with eye blocks and peripheral nerve blocks: an American Society of Anesthesiologists closed claims ana lysis. Reg Anesth Pain Med. 2008;33:416-422.
6. Mulroy MF, Hejtmanek MR. Prevention of local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010;35:177-180.
7. Neal JM. Local anesthetic systemic toxicity: improving patient safety one step at a time. Reg Anesth Pain Med. 2013;38:259-261.
8. Neal JM,Bernards CM,Butterworth JF 4th,et al. ASRA practice advisory on local anesthetic systemic toxicity Reg AnesthPainMed. 2010 35 152-161
9. Neal JM, Hsiung RL, Mulroy MF, Halpern BB, Dragnich AD, Slee AE. ASRA checkl ist improves trainee performance during a simulated episode of local anesthetic systemic toxicity. Reg Anesth Pain Med. 2012; 37:8-15.
10. Orebaugh SL, Kentor ML, Williams BA. Adverse outcomes associ ated with nerve stimulator-guided and ultrasound-guided peripheral nerve blocks by supervised trainees: update of a single-site database. Reg Anesth Pain Med. 2012;37:577-582.
11. Haahr, Mads. Random Calendar Dat e Generator, 1998-2015. Available at: https://www.random.org/calendar-dates/. Accessed November 4, 2015.
12. Barrington MJ, Kluger R. Ultrasound guidance reduces the risk of local anesthetic systemic toxicity following peripheral nerve blockade. Reg Anesth Pain Med. 2013;38:289-297.
13. Sites BD, Taenzer AH, Herrick MD, et al. Incidence of local anesthetic systemic toxicity and post operative neurologic symptoms associated with 12,668 ultrasound-guided nerve blocks: an analysis from a prospective clinical registry. Reg Anesth Pain Med. 2012;37:478-482.
14. Nunnally ME, O'Connor MF, K ordylewski H, Westlake B, Dutton RP. The incidence and risk factors for perioperative cardiac arrest observed in the national anesthesia clinical outcomes registry. Anesth Analg. 2015; 120:364-370.
15. Neal JM, Brull R, Chan VW, et al. The ASRA evidence-based medicine assessment of ultrasound-guided regional anesthesia and pain medicine: Executive summary. Reg Anesth Pain Med. 2010;35:S1-S9.
16. Liu SS, Gordon MA, Shaw PM, Wilfred S, Shetty T, YaDeau JT. A prospective clinical registry of ultrasound-guided regional anesthesia for ambulatory shoulder surgery. Anesth Analg. 2010;111:617-623.
17. McCartney CJ, Patel S. Local anesthetic volume for peripheral nerve blocks: how low can (or should) we go Reg Anesth Pain Med. 2012;37:239-241.
18. Saranteas T, Finlayson RJ, Tran de QH. Dose-finding methodology for peripheral nerve blocks. Reg Anesth Pain Med. 2014;39:550-555.
19. Lin Y, Liu SS. Local Anesthetics. In: Barash PG, Cullen BF, Stoelting RK, Cahalen M, Stock MC, Ortega R. Clinical Anesthesia. 7th ed. Philadelphia, PA. Lippincott Williams & Wilkins; 2013.
20. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373-1379.