Molecular detection of the New Delhi metallo-β-lactamase-1 gene in Enterobacteriaceae isolates in a tertiary medical centre

Malaysian Journal of Pathology

Volumn 37, Issue 3, 2015, Pages 227-232

  Zainol Abidin, Nor Zanariah ^a   Sulong, Anita ^a   Alfizah, Hanafiah ^a   Muttaqillah, Najihan Abdul Samat ^a   Ding, Chuan Hun ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA MEDICAL CENTER   (Malaysia)

Author keywords

Carbapenemase; Enterobacteriaceae; Metallo lactamase; NDM 1

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; CARBAPENEMASE; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFUROXIME; CEPHALOSPORIN; CHLORAMPHENICOL; CIPROFLOXACIN; DORIPENEM; ERTAPENEM; GENTAMICIN; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE; NEW DELHI METALLO BETA LACTAMASE 1; PIPERACILLIN PLUS TAZOBACTAM; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA-LACTAMASE NDM-1;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISK DIFFUSION; ENTEROBACTERIACEAE; ESCHERICHIA COLI; GEL ELECTROPHORESIS; KLEBSIELLA; KLEBSIELLA ORNITHINOLYTICA; KLEBSIELLA PNEUMONIAE; MALAYSIA; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; TERTIARY CARE CENTER; ANTIBIOTIC RESISTANCE; ENTEROBACTERIACEAE INFECTIONS; ENZYMOLOGY; HUMAN; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BETA-LACTAMASES; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, MICROBIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; MICROBIAL SENSITIVITY TESTS; PREVALENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TERTIARY CARE CENTERS;

EID: 84952304059     PISSN: 01268635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Yong D, Toleman MA, Giske CG, et al. Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009; 53(12): 5046-54.
2. Kumarasamy KK, Toleman MA, Walsh TR, et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis. 2010; 10(9): 597-602.
3. Livermore DM, Warner M, Mushtaq S, Doumith M, Zhang J, Woodford N. What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents. 2011; 37(5): 415-9.
4. Kus JV, Tadros M, Simor A, et al. New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection. CMAJ. 2011; 183(11): 1257-61.
5. Deshpande P, Rodrigues C, Shetty A, Kapadia F, Hedge A, Soman R. New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised. J Assoc Physicians India. 2010; 58: 147-9.
6. Walsh TR, Weeks J, Livermore DM, Toleman MA. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis. 2011; 11(5): 355-62.
7. CLSI. Performance standard for antimicrobial susceptibility testing; twenty-third informational supplement. CLSI document M100-S23. Wayne, PA: Clinical and Laboratory Standards Institute; 2013.
8. CLSI. Performance standard for antimicrobial susceptibility testing; twenty-first informational supplement. CLSI document M100-S21. Wayne, PA: Clinical and Laboratory Standards Institute; 2011.
9. Nordmann P, Poirel L, Carrër A, Toleman MA, Walsh TR. How to detect NDM-1 producers. J Clin Microbiol. 2011; 49(2): 718-21.
10. Bush K, Jacoby GA. Updated functional classification of beta-lactamases. Antimicrob Agents Chemother. 2010; 54(3): 969-76.
11. Sabath LD, Abraham EP. Zinc as a cofactor for cephalosporinase from Bacillus cereus 569. Biochem J. 1966; 98(1): 11C–13C.
12. Zou D, Huang Y, Zhao X, et al. A novel New Delhi metallo-β-lactamase variant, NDM-14, isolated in a Chinese Hospital possesses increased enzymatic activity against carbapenems. Antimicrob Agents Chemother. 2015; 59(4): 2450-3.