Small, medium but not large arteries are involved in digital ulcers associated with systemic sclerosis

Joint Bone Spine

Volumn 83, Issue 4, 2016, Pages 444-447

  Aïssou, Linda ^a,b   Meune, Christophe ^a,b,c   Avouac, Jérôme ^d,e   Meunier, Marine ^d,e   Elhaï, Muriel ^d,e   Sorbets, Emmanuel ^a,b   Kahan, André ^d,e   Allanore, Yannick ^d,e  

^a AVICENNE HOSPITAL   (France)

^b UNIVERSITÉ PARIS 13   (France)

^c University of Paris   (France)

^d INSTITUT COCHIN   (France)

^e Cochin Hospital ^*  (France)

Author keywords

Applanation tonometry; Arterial stiffness; Augmentation index; Digital ulcers; Medium arteries; Pulse wave velocity; Systemic sclerosis

Indexed keywords

ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; AUGMENTATION INDEX; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; ECHOCARDIOGRAPHY; FEMALE; FINGER ULCER; FORCED VITAL CAPACITY; HUMAN; LABORATORY TEST; LUNG DIFFUSION CAPACITY; MAJOR CLINICAL STUDY; MALE; PHYSICAL EXAMINATION; PULSE PRESSURE; PULSE WAVE; SYSTEMIC SCLEROSIS; TONOMETRY; AGE DISTRIBUTION; ANATOMY AND HISTOLOGY; ARTERY; CHI SQUARE DISTRIBUTION; COHORT ANALYSIS; COMORBIDITY; FINGER JOINT; FRANCE; INCIDENCE; MICROCIRCULATION; MIDDLE AGED; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PERIPHERAL VASCULAR DISEASES; PHYSIOLOGY; PROGNOSIS; SCLERODERMA, SYSTEMIC; SEVERITY OF ILLNESS INDEX; SEX RATIO; SKIN ULCER; TOE JOINT; VASCULARIZATION;

AGE DISTRIBUTION; AGED; ARTERIES; CHI-SQUARE DISTRIBUTION; COHORT STUDIES; COMORBIDITY; FEMALE; FINGER JOINT; FRANCE; HUMANS; INCIDENCE; MALE; MICROCIRCULATION; MIDDLE AGED; PERIPHERAL VASCULAR DISEASES; PROGNOSIS; PULSE WAVE ANALYSIS; SCLERODERMA, SYSTEMIC; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; SKIN ULCER; STATISTICS, NONPARAMETRIC; TOE JOINT; VASCULAR STIFFNESS;

EID: 84951961707     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2015.09.003     Document Type: Article

References (29)

1. Allanore Y., Meune C. Primary myocardial involvement in systemic sclerosis: evidence for a microvascular origin. Clin Exp Rheumatol 2010, 28:S48-S53.
2. Hachulla E., Clerson P., Launay D., et al. Natural history of ischemic digital ulcers in systemic sclerosis: single-center retrospective longitudinal study. J Rheumatol 2007, 34:2423-2430.
3. Tiev K.P., Diot E., Clerson P., et al. Clinical features of scleroderma patients with or without prior or current ischemic digital ulcers: post-hoc analysis of a nationwide multicenter cohort (ItinerAIR-Sclerodermie). J Rheumatol 2009, 36:1470-1476.
4. Mouthon L., Mestre-Stanislas C., Berezne A., et al. Impact of digital ulcers on disability and health-related quality of life in systemic sclerosis. Ann Rheum Dis 2010, 69:214-217.
5. Soare A., Mihai C., Dobrota R., et al. A five-year survival rate and predictors of death and disease worsening in a single-center cohort of patients with systemic sclerosis. Ann Rheum Dis 2014, 73:A42.
6. Sunderkotter C., Herrgott I., Bruckner C., et al. Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors. Br J Dermatol 2009, 160:835-843.
7. Allanore Y., Meune C., Vonk M.C., et al. Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis. Ann Rheum Dis 2010, 69:218-221.
8. Jimenez S.A. Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol 2013, 835948.
9. Allanore Y., Seror R., Chevrot A., et al. Hand vascular involvement assessed by magnetic resonance angiography in systemic sclerosis. Arthritis Rheum 2007, 56:2747-2754.
10. Sutton-Tyrrell K., Najjar S.S., Boudreau R.M., et al. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 2005, 111:3384-3390.
11. Mattace-Raso F.U., van der Cammen T.J., Hofman A., et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 2006, 113:657-663.
12. McEniery C.M., Yasmin, Hall I.R., et al. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 2005, 46:1753-1760.
13. Laurent S., Cockcroft J., Van Bortel L., et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006, 27:2588-2605.
14. Cypiene A., Laucevicius A., Venalis A., et al. The impact of systemic sclerosis on arterial wall stiffness parameters and endothelial function. Clin Rheumatol 2008, 27:1517-1522.
15. Ngian G.S., Sahhar J., Wicks I.P., et al. Arterial stiffness is increased in systemic sclerosis: a cross-sectional comparison with matched controls. Clin Exp Rheumatol 2014, 32:S-161-S-166.
16. Domsic R.T., Dezfulian C., Shoushtari A., et al. Endothelial dysfunction is present only in the microvasculature and microcirculation of early diffuse systemic sclerosis patients. Clin Exp Rheumatol 2014, 32:S-154-S-160.
17. LeRoy E.C., Black C., Fleischmajer R., et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988, 15:202-205.
18. Allanore Y., Borderie D., Avouac J., et al. High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis. Arthritis Rheum 2008, 58:284-291.
19. Meune C., Avouac J., Airo P., et al. Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations. Arthritis Rheum 2011, 63:2790-2796.
20. Hoeper M.M. Definition, classification, and epidemiology of pulmonary arterial hypertension. Semin Respir Crit Care Med 2009, 30:369-375.
21. Meune C., Mahe I., Mourad J.J., et al. Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect. Eur J Heart Fail 2003, 5:271-279.
22. Blacher J., Guerin A.P., Pannier B., et al. Impact of aortic stiffness on survival in end-stage renal disease. Circulation 1999, 99:2434-2439.
23. Safar M.E., Lacolley P. Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage. Am J Physiol Heart Circ Physiol 2007, 293:H1-H7.
24. Mackenzie I.S., Wilkinson I.B., Cockcroft J.R. Assessment of arterial stiffness in clinical practice. QJM 2002, 95:67-74.
25. Blacher J., Asmar R., Djane S., et al. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999, 33:1111-1117.
26. Denton C.P., Krieg T., Guillevin L., et al. Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry. Ann Rheum Dis 2012, 71:718-721.
27. Cozzi F., Pigatto E., Rizzo M., et al. Low occurrence of digital ulcers in scleroderma patients treated with bosentan for pulmonary arterial hypertension: a retrospective case-control study. Clin Rheumatol 2013, 32:679-683.
28. Roman Ivorra J.A., Simeon C.P., Alegre Sancho J.J., et al. Bosentan in clinical practice for treating digital and other ischemic ulcers in Spanish patients with systemic sclerosis: IBER-DU cohort study. J Rheumatol 2011, 38:1631-1635.
29. Ong K.T., Delerme S., Pannier B., et al. Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients. J Hypertens 2011, 29:1034-1042.