Pediatric nonalcoholic fatty liver disease: A report from the expert committee on nonalcoholic fatty liver disease (ECON)

Journal of Pediatrics

Volumn 172, Issue , 2016, Pages 9-13

  Kohli, Rohit ^a   Sunduram, Shikha ^b   Mouzaki, Marialena ^c   Ali, Sabina ^d   Sathya, Pushpa ^e   Abrams, Stephanie ^f   Xanthakos, Stavra A ^a   Vos, Miriam ^g   Schwimmer, Jeffrey B ^h,i  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL COLORADO   (United States)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d STANFORD UNIVERSITY   (United States)

^e MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^f Memorial Care   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

ⁱ RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALANINE AMINOTRANSFERASE; ALPHA TOCOPHEROL; BIOLOGICAL MARKER; MERCAPTAMINE; OBETICHOLIC ACID; PENTOXIFYLLINE;

ARTICLE; CHILD; CHILDHOOD DISEASE; CHILDHOOD MORTALITY; COMORBIDITY; CORONARY ARTERY ATHEROSCLEROSIS; DIAGNOSTIC IMAGING; DISEASE COURSE; ECHOGRAPHY; HUMAN; LIVER BIOPSY; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER TRANSPLANTATION; MEDICAL RESEARCH; NON INVASIVE PROCEDURE; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PATIENT SAFETY; PEDIATRIC NONALCOHOLIC FATTY LIVER DISEASE; PREDICTIVE VALUE; PRIORITY JOURNAL; SLEEP DISORDERED BREATHING; STEATOSIS; CHILDHOOD OBESITY; COMPLICATION; LIVER; PATHOLOGY;

CHILD; HUMANS; LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; PEDIATRIC OBESITY;

EID: 84951957544     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2015.12.016     Document Type: Article

References (59)

1. S. Xanthakos, L. Miles, J. Bucuvalas, S. Daniels, V. Garcia, and T. Inge Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents Clin Gastroenterol Hepatol 4 2006 226 232
2. M. Machado, P. Marques-Vidal, and H. Cortez-Pinto Hepatic histology in obese patients undergoing bariatric surgery J Hepatol 45 2006 600 606
3. J.A. Welsh, S. Karpen, and M.B. Vos Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010 J Pediatr 162 2013 496 500.e1
4. A.K.H. Hesham Nonalcoholic fatty liver disease in children living in the obeseogenic society World J Pediatr 5 2009 245 254
5. S. Berardis, and E. Sokal Pediatric non-alcoholic fatty liver disease: an increasing public health issue Eur J Pediatr 173 2014 131 139
6. J.B. Schwimmer, R. Deutsch, T. Kahen, J.E. Lavine, C. Stanley, and C. Behling Prevalence of fatty liver in children and adolescents Pediatrics 118 2006 1388 1393
7. K. Das, K. Das, P.S. Mukherjee, A. Ghosh, S. Ghosh, A.R. Mridha, and et al. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease Hepatology 51 2010 1593 1602
8. I.H. Bahcecioglu, M. Koruk, O. Yilmaz, C. Bolukbas, F. Bolukbas, I. Tuncer, and et al. Demographic and clinicopathological characteristics of nonalcoholic fatty liver disease in the East-Southeastern Anatolia regions in Turkey Med Princ Pract 15 2006 62 68
9. X. Zhang, Y. Wan, S. Zhang, L. Lu, Z. Chen, H. Liu, and et al. Nonalcoholic fatty liver disease prevalence in urban school-aged children and adolescents from the Yangtze River delta region: a cross-sectional study Asia Pac J Clin Nutr 24 2015 281 288
10. C. Wah-Kheong, and G. Khean-Lee Epidemiology of a fast emerging disease in the Asia-Pacific region: non-alcoholic fatty liver disease Hepatol Int 7 2013 65 71
11. M. Rorat, T. Jurek, E. Kuchar, L. Szenborn, W. Golema, and A. Halon Liver steatosis in Polish children assessed by medicolegal autopsies World J Pediatr 9 2013 68 72
12. J.P. Molleston, J.B. Schwimmer, K.P. Yates, K.F. Murray, O.W. Cummings, J.E. Lavine, and et al. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels J Pediatr 164 2014 707 713.e3
13. R. Kohli, T. Boyd, K. Lake, K. Dietrich, L. Nicholas, W.F. Balistreri, and et al. Rapid progression of NASH in childhood J Pediatr Gastroenterol Nutr 50 2010 453 456
14. M. Ekstedt, L.E. Franzen, U.L. Mathiesen, L. Thorelius, M. Holmqvist, G. Bodemar, and et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes Hepatology 44 2006 865 873
15. A.E. Feldstein, P. Charatcharoenwitthaya, S. Treeprasertsuk, J.T. Benson, F.B. Enders, and P. Angulo The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years Gut 58 2009 1538 1544
16. S. Gokce, Z. Atbinici, Z. Aycan, H.G. Cinar, and P. Zorlu The relationship between pediatric nonalcoholic fatty liver disease and cardiovascular risk factors and increased risk of atherosclerosis in obese children Pediatr Cardiol 34 2013 308 315
17. J.B. Schwimmer, P.E. Pardee, J.E. Lavine, A.K. Blumkin, and S. Cook Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease Circulation 118 2008 277 283
18. P.E. Pardee, W. Dunn, and J.B. Schwimmer Non-alcoholic fatty liver disease is associated with low bone mineral density in obese children Aliment Pharmacol Ther 35 2012 248 254
19. K.D. Kistler, J. Molleston, A. Unalp, S.H. Abrams, C. Behling, J.B. Schwimmer, and et al. Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver disease Aliment Pharmacol Ther 31 2010 396 406
20. H.M. Patton, J.E. Lavine, M.L. Van Natta, J.B. Schwimmer, D. Kleiner, J. Molleston, and et al. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis Gastroenterology 135 2008 1961 1971.e2
21. A. Yuce, N. Kocak, H. Ozen, and F. Gurakan Wilson's disease patients with normal ceruloplasmin levels Turk J Pediatr 41 1999 99 102
22. S. Mahmood, N. Inada, A. Izumi, M. Kawanaka, H. Kobashi, and G. Yamada Wilson's disease masquerading as nonalcoholic steatohepatitis N Am J Med Sci 1 2009 74 76
23. C. Potter, M.J. Hogan, K. Henry-Kendjorsky, J. Balint, and J.A. Barnard Safety of pediatric percutaneous liver biopsy performed by interventional radiologists J Pediatr Gastroenterol Nutr 53 2011 202 206
24. A.O. Scheimann, J.M. Barrios, Y.S. Al-Tawil, K.M. Gray, and M.A. Gilger Percutaneous liver biopsy in children: impact of ultrasonography and spring-loaded biopsy needles J Pediatr Gastroenterol Nutr 31 2000 536 539
25. J.B. Schwimmer, K.P. Newton, H.I. Awai, L.J. Choi, M.A. Garcia, L.L. Ellis, and et al. Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non-alcoholic fatty liver disease Aliment Pharmacol Ther 38 2013 1267 1277
26. L. Pacifico, M. Celestre, C. Anania, P. Paolantonio, C. Chiesa, and A. Laghi MRI and ultrasound for hepatic fat quantification:relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease Acta Paediatr 96 2007 542 547
27. S. Cournane, J.E. Browne, and A.J. Fagan The effects of fatty deposits on the accuracy of the Fibroscan(R) liver transient elastography ultrasound system Phys Med Biol 57 2012 3901 3914
28. R.P. Myers, G. Pomier-Layrargues, R. Kirsch, A. Pollett, A. Duarte-Rojo, D. Wong, and et al. Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients Hepatology 55 2012 199 208
29. M. Yoneda, M. Yoneda, H. Mawatari, K. Fujita, H. Endo, H. Iida, and et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD) Dig Liver Dis 40 2008 371 378
30. J.B. Schwimmer, M.S. Middleton, C. Behling, K.P. Newton, H.I. Awai, M.N. Paiz, and et al. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease Hepatology 61 2015 1887 1895
31. S.A. Xanthakos, D.J. Podberesky, S.D. Serai, L. Miles, E.C. King, W.F. Balistreri, and et al. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease J Pediatr 164 2014 186 188
32. H.I. Awai, K.P. Newton, C.B. Sirlin, C. Behling, and J.B. Schwimmer Evidence and recommendations for imaging liver fat in children, based on systematic review Clin Gastroenterol Hepatol 12 2014 765 773
33. S.B. Reeder, H.H. Hu, and C.B. Sirlin Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration J Magn Reson Imaging 36 2012 1011 1014
34. J.B. Schwimmer, A. Zepeda, K.P. Newton, S.A. Xanthakos, C. Behling, E.K. Hallinan, and et al. Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease PLoS One 9 2014 e112569
35. D. Fintini, M. Chinali, G. Cafiero, C. Esposito, U. Giordano, A. Turchetta, and et al. Early left ventricular abnormality/dysfunction in obese children affected by NAFLD Nutr Metab Cardiovasc Dis 24 2014 72 74
36. S.S. Sundaram, R.J. Sokol, K.E. Capocelli, Z. Pan, J.S. Sullivan, K. Robbins, and et al. Obstructive sleep apnea and hypoxemia are associated with advanced liver histology in pediatric nonalcoholic fatty liver disease J Pediatr 164 2014 699 706.e1
37. V. Nobili, R. Cutrera, D. Liccardo, M. Pavone, R. Devito, V. Giorgio, and et al. Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance Am J Respir Crit Care Med 189 2014 66 76
38. L. Pacifico, M. Bezzi, C.V. Lombardo, S. Romaggioli, F. Ferraro, S. Bascetta, and et al. Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease World J Gastroenterol 19 2013 4007 4014
39. J.B. Schwimmer, W. Dunn, G.J. Norman, P.E. Pardee, M.S. Middleton, N. Kerkar, and et al. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease Gastroenterology 138 2010 1357 1364 64.e1-2
40. S.E. Barlow, and C. Expert Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report Pediatrics 120 Suppl 4 2007 S164 S192
41. P. Vajro, S. Lenta, P. Socha, A. Dhawan, P. McKiernan, U. Baumann, and et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee J Pediatr Gastroenterol Nutr 54 2012 700 713
42. M.B. Vos, R. Colvin, P. Belt, J.P. Molleston, K.F. Murray, P. Rosenthal, and et al. Correlation of Vitamin E, Uric Acid, and Diet Composition With Histologic Features of Pediatric NAFLD J Pediatr Gastroenterol Nutr 54 2012 90 96
43. R. Kohli There's more under the nonalcoholic fatty liver disease umbrella than an elevated alanine aminotransferase level J Pediatr 164 2014 684 686
44. J.E. Lavine, and J.B. Schwimmer Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children J Pediatr Gastroenterol Nutr 42 2006 129 130
45. A. Zarrinpar, and R.W. Busuttil Liver transplantation: past, present and future Nat Rev Gastroenterol Hepatol 10 2013 434 440
46. J. Ertle, A. Dechêne, J.P. Sowa, V. Penndorf, K. Herzer, G. Kaiser, and et al. Non-alcoholic fatty liver disease progresses to Hcc in the absence of cirrhosis Int J Cancer 128 2011 2436 2443
47. N. Kemmer, G.W. Neff, E. Franco, H. Osman-Mohammed, J. Leone, E. Parkinson, and et al. Nonalcoholic fatty liver disease epidemic and its implications for liver transplantation Transplantation 96 2013 860 862
48. R.J. Wong, M. Aguilar, R. Cheung, R.B. Perumpail, S.A. Harrison, Z.M. Younossi, and et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States Gastroenterology 148 2015 547 555
49. R. Hernandez-Alejandro, K.P. Croome, M. Drage, N. Sela, J. Parfitt, N. Chandok, and et al. A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma World J Gastroenterol 18 2012 4145 4149
50. M. Heuer, G.M. Kaiser, A. Kahraman, M. Banysch, F.H. Saner, Z. Mathe, and et al. Liver transplantation in nonalcoholic steatohepatitis is associated with high mortality and post-transplant complications: a single-center experience Digestion 86 2012 107 113
51. B.C. Sharma, A. Kumar, V. Garg, R.S. Reddy, P. Sakhuja, and S.K. Sarin A randomized controlled trial comparing efficacy of pentoxifylline and pioglitazone on metabolic factors and liver histology in patients with non-alcoholic steatohepatitis J Clin Exp Hepatol 2 2012 333 337
52. C.O. Zein, L.M. Yerian, P. Gogate, R. Lopez, J.P. Kirwan, A.E. Feldstein, and et al. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial Hepatology 54 2011 1610 1619
53. L.B. Van Wagner, S.W. Koppe, E.M. Brunt, J. Gottstein, K. Gardikiotes, R.M. Green, and et al. Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial Ann Hepatol 10 2011 277 286
54. N. Sturm, J.P. Bronowicki, M. Maynard-Muet, A. Tran, F. Heluwaert, A. Plages, and et al. Metformin plus pentoxifylline versus prescriptive diet in non-alcoholic steatohepatitis (NASH): a randomized controlled pilot trial Gastroenterol Clin Biol 33 2009 984 986
55. L.A. Adams, C.O. Zein, P. Angulo, and K.D. Lindor A pilot trial of pentoxifylline in nonalcoholic steatohepatitis Am J Gastroenterol 99 2004 2365 2368
56. B.A. Neuschwander-Tetri, R. Loomba, A.J. Sanyal, J.E. Lavine, M.L. Van Natta, M.F. Abdelmalek, and et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial Lancet 385 2015 956 965
57. J.E. Lavine, J.B. Schwimmer, M.L. Van Natta, J.P. Molleston, K.F. Murray, P. Rosenthal, and et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial JAMA 305 2011 1659 1668
58. J.E. Lavine Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study J Pediatr 136 2000 734 738
59. R. Dohil, S. Schmeltzer, B.L. Cabrera, T. Wang, J. Durelle, K.B. Duke, and et al. Enteric-coated cysteamine for the treatment of paediatric non-alcoholic fatty liver disease Aliment Pharmacol Ther 33 2011 1036 1044