Assessment of the stability of mephedrone in ante-mortem and post-mortem blood specimens

Forensic Science International

Volumn 256, Issue , 2015, Pages 28-37

  Busardò, Francesco Paolo ^a   Kyriakou, Chrystalla ^a   Tittarelli, Roberta ^a   Mannocchi, Giulio ^a   Pantano, Flaminia ^a   Santurro, Alessandro ^a   Zaami, Simona ^a   Baglìo, Giovanni ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Blood samples; Forensic toxicology; Mephedrone; Stability

Indexed keywords

4' METHYLMETHCATHINONE; EDETIC ACID; OXALIC ACID DERIVATIVE; SODIUM FLUORIDE; FIXATIVE; METHAMPHETAMINE; STREET DRUG;

ADULT; ANTEMORTEM BLOOD SAMPLING; ARTICLE; AUTOPSY; BLOOD ANALYSIS; BLOOD SAMPLING; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG USE; FEMALE; FORENSIC TOXICOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; POSTMORTEM BLOOD SAMPLING; PRIORITY JOURNAL; TEMPERATURE; ANALOGS AND DERIVATIVES; BLOOD; CHEMISTRY; DRUG STABILITY; MASS FRAGMENTOGRAPHY; MIDDLE AGED; POSTMORTEM CHANGE; SPECIMEN HANDLING;

ADULT; DRUG STABILITY; FIXATIVES; FORENSIC TOXICOLOGY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; METHAMPHETAMINE; MIDDLE AGED; POSTMORTEM CHANGES; SPECIMEN HANDLING; STREET DRUGS; TEMPERATURE;

EID: 84951940701     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2015.07.021     Document Type: Article

References (28)

1. Schifano F., Albanese A., Fergus S., Stair J.L., Deluca P., Corazza O., Davey Z., Corkery J., Siemann H., Scherbaum N., Farrè M., Torrens M., Demetrovics Z., Ghosde A.H. Mephedrone (4-methylmethcathinone; 'meow meow'): chemical, pharmacological and clinical issues. Psychopharmacology (Berl.) 2011, 214:593-602.
2. Winstock A.R., Marsden J., Mitcheson L. What should be done about mephedrone?. BMJ 2010, 340:1605.
3. Angoa-Perez M., Kane M.J., Francescutti D.M., Sykes K.E., Shah M.M., Mohammed A.M., Thomas D.M., Kuhn D.M. Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum. J. Neurochem. 2012, 120:1097-1107.
4. Winstock A., Mitcheson L., Marsden J. Mephedrone: still available and twice the price. Lancet 2010, 376:1537.
5. Winstock A.R., Mitcheson L.R., Deluca P., Davey Z., Corazza O., Schifano F. Mephedrone, new kid for the chop?. Addiction 2011, 106:154-161.
6. Dargan P.I., Albert S., Wood D.M. Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change. QJM 2010, 103:875-879.
7. Camilleri A., Johnston M.R., Brennan M., Davis S., Caldicott D.G. Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone. Forensic Sci. Int. 2010, 197:59-66.
8. Wikström M., Thelander G., Nyström I., Kronstrand R. Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone). J. Anal. Toxicol. 2010, 34:594-598.
9. Lusthof K.J., Oosting R., Maes A., Verschraagen M., Dijkhuizen A., Sprong A.G. A case of extreme agitation and death after the use of mephedrone in The Netherlands. Forensic Sci. Int. 2011, 206:e93-e95.
10. Maskell P.D., De Paoli G., Seneviratne C., Pounder D.J. Mephedrone (4-methylmethcathinone)-related deaths. J. Anal. Toxicol. 2011, 35:188-191.
11. Adamowicz P., Tokarczyk B., Stanaszek R., Slopianka M. Fatal mephedrone intoxication - a case report. J. Anal. Toxicol. 2013, 37:37-42.
12. Dickson A.J., Vorce S.P., Levine B., Past M.R. Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. J. Anal. Toxicol. 2010, 34:162-168.
13. Gerace E., Petrarulo M., Bison F., Salomone A., Vincenti M. Toxicological findings in a fatal multidrug intoxication involving mephedrone. Forensic Sci. Int. 2014, 243C:68-73.
14. Torrance H., Cooper G. The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland. Forensic Sci. Int. 2010, 202:62-63.
15. Peters F.T., Drummer O.H., Musshoff F. Validation of new methods. Forensic Sci. Int. 2007, 165:216-224.
16. Peters F.T. Stability of analytes in biosamples - an important issue in clinical and forensic toxicology. Anal. Bioanal. Chem. 2007, 388:1505-1519.
17. Holmgren P., Druid H., Holmgren A., Ahlner J. Stability of drugs in stored postmortem femoral blood and vitreous humor. J. Forensic. Sci. 2004, 49:820-825.
18. Heller S., Hiemke C., Stroba G., Rieger-Gies A., Daum-Kreysch E., Sachse J., Härtter S. Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM service. Ther. Drug Monit. 2004, 4:459-461.
19. Busardò F.P., Bertol E., Vaiano F., Baglio G., Montana A., Barbera N., Zaami S., Romano G. Post mortem concentrations of endogenous gamma hydroxybutyric acid (GHB) and in vitro formation in stored blood and urine samples. Forensic Sci. Int. 2014, 243:144-148.
20. Busardò F.P., Jones A.W. GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome. Curr. Neuropharmacol. 2014, 10.2174/1570159X13666141210215423.
21. Drummer O.H. Requirements for bioanalytical procedures in postmortem toxicology. Anal. Bioanal. Chem. 2007, 388:1495-1503.
22. Drummer O.H. Postmortem toxicology of drugs of abuse. Forensic Sci. Int. 2004, 142:101-113.
23. Høiseth G., Fjeld B., Burns M.L., Strand D.H., Vindenes V. Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20°C. Forensic Sci. Int. 2014, 239:6-10.
24. Fisher D.S., Partridge S.J., Handley S.A., Flanagan R.J. Stability of some atypical antipsychotics in human plasma, haemolysed whole blood, oral fluid, human serum and calf serum. Forensic Sci. Int. 2013, 229:151-156.
25. Johnson R.D., Botch Jones S.R. The stability of four designer drugs: MDPV, mephedrone, BZP and TFMPP in three biological matrices under various storage conditions. J. Anal. Toxicol. 2013, 37:51-55.
26. Sørensen L.K. Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography-electrospray tandem mass spectrometry. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2011, 879:727-736.
27. Tsujikawa K., Mikuma T., Kuwayama K., Miyaguchi H., Kanamori T., Iwata Y.T., Inoue H. Degradation pathways of 4-methylmethcathinone in alkaline solution and stability of methcathinone analogs in various pH solutions. Forensic Sci. Int. 2012, 220:103-110.
28. Maskell P.D., Seetohul L.N., Livingstone A.C., Cockburn A.K., Preece J., Pounder D.J. Stability of 3,4-methylenedioxymethampetamine (MDMA), 4-methylmethcathinone (mephedrone) and 3 trifluromethylphenylpiperazine (3-TFMPP) in formalin solution. J. Anal. Toxicol. 2013, 37:440-446.