Development of a Genetic Algorithm Method Especially Designed for the Comparison of Molecular Models: Application to the Elucidation of the Benzodiazepine Receptor Pharmacophore

Computer-Assisted Lead Finding and Optimization: Current Tools for Medicinal Chemistry

Volumn , Issue , 2007, Pages 497-509

  Meurice, Nathalie ^a   Leherte, Laurence ^a   Vercauteren, Daniel P ^a   Bourguignon, Jean Jacques ^b   Wermuth, Camille G ^b  

^a UNIVERSITY OF NAMUR   (Belgium)

^b CENTRE DE NEUROCHIMIE   (France)

Author keywords

Benzodiazepine receptor pharmacophore; Comparison of molecular models; Genetic algorithm method

Indexed keywords

BINDING SITES; GENETIC ALGORITHMS; MOLECULAR MODELING; PHARMACODYNAMICS; TOPOLOGY;

ELECTRON DENSITY MAPS; INTERACTION MODES; MOLECULAR FRAGMENTS; PHARMACOPHORES; SIMULATION PROGRAM; STRUCTURE FACTORS; THREE-DIMENSIONAL MAPS; TOPOLOGICAL ANALYSIS;

LIGANDS;

EID: 84951798015     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783906390406.ch32     Document Type: Chapter

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