Environmental enteropathy

Current Opinion in Gastroenterology

Volumn 32, Issue 1, 2016, Pages

  Ali, Asad ^a   Iqbal, Najeeha T ^a   Sadiq, Kamran ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

Biomarkers; environmental enteric dysfunction; environmental enteropathy; malnutrition

Indexed keywords

BACTERIAL TRANSLOCATION; ENTERITIS; ENTEROPATHY; ENVIRONMENTAL ENTEROPATHY; EXOCRINE SECRETION; HISTOPATHOLOGY; HUMAN; INFLAMMATION; INTESTINE BIOPSY; INTESTINE MUCOSA PERMEABILITY; MALNUTRITION; PERMEABILITY BARRIER; REVIEW; CHILD; DEVELOPING COUNTRY; DIET THERAPY; DIFFERENTIAL DIAGNOSIS; FECES; MALABSORPTION SYNDROMES; MICROBIOLOGY; PATHOLOGY; PRESCHOOL CHILD; PROCEDURES; QUALITY OF LIFE;

BIOLOGICAL MARKER; CALGRANULIN; MESALAZINE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOMARKERS; CHILD; CHILD, PRESCHOOL; DEVELOPING COUNTRIES; DIAGNOSIS, DIFFERENTIAL; FECES; HUMANS; LEUKOCYTE L1 ANTIGEN COMPLEX; MALABSORPTION SYNDROMES; MALNUTRITION; MESALAMINE; NUTRITION THERAPY; QUALITY OF LIFE;

EID: 84951569998     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000226     Document Type: Review

References (38)

1. Keusch GT, Rosenberg IH, Denno DM, et al. Implications of acquired environmental enteric dysfunction for growth and stunting in infants and children living in low-and middle-income countries. Food Nutr Bull 2013; 34:357-364.
2. Ramakrishna BS, Venkataraman S, Mukhopadhya A. Tropical malabsorption. Postgrad Med J 2006; 82:779-787.
3. Veitch AM, Kelly P, Zulu IS, et al. Tropical enteropathy: a T-cell-mediated crypt hyperplastic enteropathy. Eur J Gastroenterol Hepatol 2001; 13:1175-1181.
4. Sullivan PB, Marsh MN. Small intestinal mucosal histology in the syndrome of persistent diarrhoea and malnutrition: a review. Acta Paediatr Suppl 1992; 381:72-77.
5. Sullivan PB, Lunn PG, Northrop-Clewes C, et al. Persistent diarrhea and malnutrition-the impact of treatment on small bowel structure and permeability. J Pediatr Gastroenterol Nutr 1992; 14:208-215.
6. Campbell DI, Murch SH, Elia M, et al. Chronic T cell-mediated enteropathy in rural west African children: relationship with nutritional status and small bowel function. Pediatr Res 2003; 54:306-311.
7. Korpe PS, Petri WA Jr. Environmental enteropathy: critical implications of a poorly understood condition. Trends Mol Med 2012; 18:328-336.
8. http://gcgh.grandchallenges.org/Pages/GCGHGrantsAwarded.aspx TDateGut%20Function%20Biomarkers%20-%20December%202012.
9. Campbell DI, Elia M, Lunn PG. Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. J Nutr 2003; 133:1332-1338.
10. Campbell DI, Lunn PG, Elia M. Age-related association of small intestinal mucosal enteropathy with nutritional status in rural Gambian children. Br J Nutr 2002; 88:499-505.
11. Campbell DI, McPhail G, Lunn PG, et al. Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy: association with growth failure, Giardia lamblia, and intestinal permeability. J Pediatr Gastroenterol Nutr 2004; 39:153-157.
12. Goto R, Panter-Brick C, Northrop-Clewes CA, et al. Poor intestinal permeability in mildly stunted Nepali children: associations with weaning practices and Giardia lamblia infection. Br J Nutr 2002; 88:141-149.
13. Goto R, Mascie-Taylor CG, Lunn PG. Impact of intestinal permeability, inflammation status and parasitic infections on infant growth faltering in rural Bangladesh. Br J Nutr 2009; 101:1509-1516.
14. Filteau SM, Rollins NC, Coutsoudis A, et al. The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. J Pediatr Gastroenterol Nutr 2001; 32:464-470.
15. Lee GO, Kosek P, Lima AA, et al. Lactulose: mannitol diagnostic test by HPLC and LC-MSMS platforms: considerations for field studies of intestinal barrier function and environmental enteropathy. J Pediatr Gastroenterol Nutr 2000; 59:544-550.
16. Kosek M, Haque R, Lima A, et al. Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hyg 2012; 88:390-396.
17. Fuchs D, Granditsch G, Hausen A, et al. Urinary neopterin excretion in coeliac disease. Lancet 1983; 2:463-464.
18. Theede K, Holck S, Ibsen P, et al. Level of fecal calprotectin correlates with endoscopic and histologic inflammation and identifies patients with mucosal healing of ulcerative colitis. Clin Gastroenterol Hepatol 2015. [Epub ahead of print]
19. Li F, Ma J, Geng S, et al. Fecal calprotectin concentrations in healthy children aged 1-18 months. PLoS One 2015; 10:e0119574.
20. Hestvik E, Tumwine JK, Tylleskar T, et al. Faecal calprotectin concentrations in apparently healthy children aged 0-12 years in urban Kampala, Uganda: a community-based survey. BMC Pediatr 2011; 11:9.
21. van der Merwe LF, Moore SE, Fulford AJ, et al. Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. Am J Clin Nutr 2012; 97:45-57.
22. Levine MM. Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine. BMC Biol 2010; 8:129.
23. Sanchez D, Figarella C, Marchand-Pinatel S, et al. Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun 2001; 284:729-737.
24. Planas R, Pujol-Autonell I, Ruiz E, et al. Regenerating gene Ialpha is a biomarker for diagnosis and monitoring of celiac disease: a preliminary study. Transl Res 2011; 158:140-145.
25. Dieckgraefe BK, Crimmins DL, Landt V, et al. Expression of the regenerating gene family in inflammatory bowel disease mucosa: Reg Ialpha upregulation, processing, and antiapoptotic activity. J Investig Med 2002; 50:421-434.
26. Sekikawa A, Fukui H, Fujii S, et al. REG Ialpha protein may function as a trophic and/or antiapoptotic factor in the development of gastric cancer. Gastroenterology 2005; 128:642-653.
27. Peterson KM, Buss J, Easley R, et al. REG1B as a predictor of childhood stunting in Bangladesh and Peru. Am J Clin Nutr 2013; 97:1129-1133.
28. Benzoni N, Korpe P, Thakwalakwa C, et al. Plasma endotoxin core antibody concentration and linear growth are unrelated in rural Malawian children aged 2-5 years. BMC Res Notes 2015; 8:258.
29. Prendergast AJ, Rukobo S, Chasekwa B, et al. Stunting is characterized by chronic inflammation in Zimbabwean infants. PLoS One 2014; 9:e86928.
30. Lin A, Arnold BF, Afreen S, et al. Household environmental conditions are associated with enteropathy and impaired growth in rural Bangladesh. Am J Trop Med Hyg 2013; 89:130-137.
31. Fournier T, Medjoubi NN, Porquet D. Alpha-1-acid glycoprotein. Biochim Biophys Acta 2000; 1482:157-171.
32. Bartz S, Mody A, Hornik C, et al. Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality. J Clin Endocrinol Metab 2014; 99:2128-2137.
33. Petri WA Jr, Naylor C, Haque R. Environmental enteropathy and malnutrition: do we know enough to intervene BMC Med 2014; 12:187.
34. Roura E, Homedes J, Klasing KC. Prevention of immunologic stress contributes to the growth-permitting ability of dietary antibiotics in chicks. J Nutr 1992; 122:2383-2390.
35. Jones KD, Hunten-Kirsch B, Laving AM, et al. Mesalazine in the initial management of severely acutely malnourished children with environmental enteric dysfunction: a pilot randomized controlled trial. BMC Med 2014; 12:133.
36. Trehan I, Shulman RJ, Ou CN, et al. A randomized, double-blind, placebocontrolled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. Am J Gastroenterol 2009; 104:2326-2333.
37. Young GP, Mortimer EK, Gopalsamy GL, et al. Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshop. Am J Clin Nutr 2014; 100:1198-1207.
38. Louis-Auguste J, Greenwald S, Simuyandi M, et al. High dose multiple micronutrient supplementation improves villous morphology in environmental enteropathy without HIV enteropathy: results from a double-blind randomised placebo controlled trial in Zambian adults. BMC Gastroenterol 2014; 14:15.