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Volumn 141, Issue 11, 2015, Pages 1945-1952

The prognostic impact of EGFR, ErbB2 and MET gene amplification in human gastric carcinomas as measured by quantitative Real-Time PCR

Author keywords

EGFR; ErbB2; Gastric cancer; Gene amplification; MET

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; KI 67 ANTIGEN; MESSENGER RNA; EGFR PROTEIN, HUMAN; ERBB2 PROTEIN, HUMAN; MET PROTEIN, HUMAN; SCATTER FACTOR RECEPTOR;

EID: 84951569781     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-1965-7     Document Type: Article
Times cited : (22)

References (42)
  • 1
    • 54949137348 scopus 로고    scopus 로고
    • Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie
    • PID: 18669868
    • Al-Batran S-E, Hartmann JT, Hofheinz R et al (2008) Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie. Ann Oncol 19:1882–1887. doi:10.1093/annonc/mdn403
    • (2008) Ann Oncol , vol.19 , pp. 1882-1887
    • Al-Batran, S.-E.1    Hartmann, J.T.2    Hofheinz, R.3
  • 2
    • 33746255899 scopus 로고    scopus 로고
    • Gene amplification in cancer
    • COI: 1:CAS:528:DC%2BD28XntlCksbs%3D, PID: 16787682
    • Albertson DG (2006) Gene amplification in cancer. Trends Genet 22:447–455. doi:10.1016/j.tig.2006.06.007
    • (2006) Trends Genet , vol.22 , pp. 447-455
    • Albertson, D.G.1
  • 3
    • 0036362221 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dependence in human tumors: more than just expression?
    • COI: 1:CAS:528:DC%2BD38XnsFOiurg%3D, PID: 12202786
    • Arteaga CL (2002) Epidermal growth factor receptor dependence in human tumors: more than just expression? Oncologist 7(Suppl 4):31–39. doi:10.1634/theoncologist.7-suppl_4-31
    • (2002) Oncologist , vol.7 , pp. 31-39
    • Arteaga, C.L.1
  • 4
    • 84868703338 scopus 로고    scopus 로고
    • The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer
    • COI: 1:CAS:528:DC%2BC3sXjtVKitrw%3D, PID: 23153332
    • Atmaca A, Werner D, Pauligk C et al (2012) The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer. BMC Cancer 12:524. doi:10.1186/1471-2407-12-524
    • (2012) BMC Cancer , vol.12 , pp. 524
    • Atmaca, A.1    Werner, D.2    Pauligk, C.3
  • 5
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
    • COI: 1:CAS:528:DC%2BC3cXhtVymt7zO, PID: 20728210
    • Bang Y-J, Van Cutsem E, Feyereislova A et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376:687–697. doi:10.1016/S0140-6736(10)61121-X
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.-J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 6
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • COI: 1:CAS:528:DC%2BC3cXitFemsr0%3D, PID: 20164920
    • Beroukhim R, Mermel CH, Porter D et al (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463:899–905. doi:10.1038/nature08822
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3
  • 8
    • 3442890204 scopus 로고    scopus 로고
    • Role of HER receptors family in development and differentiation
    • COI: 1:CAS:528:DC%2BD2cXmtlKju70%3D, PID: 15254961
    • Casalini P, Iorio MV, Galmozzi E, Ménard S (2004) Role of HER receptors family in development and differentiation. J Cell Physiol 200:343–350. doi:10.1002/jcp.20007
    • (2004) J Cell Physiol , vol.200 , pp. 343-350
    • Casalini, P.1    Iorio, M.V.2    Galmozzi, E.3    Ménard, S.4
  • 9
    • 0035433109 scopus 로고    scopus 로고
    • MET mutation and familial gastric cancer
    • COI: 1:STN:280:DC%2BD38%2Fisl2lug%3D%3D, PID: 11483642
    • Chen JD, Kearns S, Porter T et al (2001) MET mutation and familial gastric cancer. J Med Genet 38:E26. doi:10.1136/jmg.38.8.e26
    • (2001) J Med Genet , vol.38 , pp. E26
    • Chen, J.D.1    Kearns, S.2    Porter, T.3
  • 10
    • 77649332271 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • COI: 1:CAS:528:DC%2BC3cXivVOhsLg%3D, PID: 20200397
    • Cunningham D, Okines AFC, Ashley S (2010) Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 362:858–859. doi:10.1056/NEJMc0911925
    • (2010) N Engl J Med , vol.362 , pp. 858-859
    • Cunningham, D.1    Okines, A.F.C.2    Ashley, S.3
  • 11
    • 34250630933 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery
    • PID: 17516110
    • Galizia G, Lieto E, Orditura M et al (2007) Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery. World J Surg 31:1458–1468. doi:10.1007/s00268-007-9016-4
    • (2007) World J Surg , vol.31 , pp. 1458-1468
    • Galizia, G.1    Lieto, E.2    Orditura, M.3
  • 12
    • 3042767348 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: a multivariate analysis using a standardized immunohistochemical detection system
    • COI: 1:CAS:528:DC%2BD2cXmsVOitro%3D, PID: 15073595
    • Gamboa-Dominguez A, Dominguez-Fonseca C, Quintanilla-Martinez L et al (2004) Epidermal growth factor receptor expression correlates with poor survival in gastric adenocarcinoma from Mexican patients: a multivariate analysis using a standardized immunohistochemical detection system. Mod Pathol 17:579–587. doi:10.1038/modpathol.3800085
    • (2004) Mod Pathol , vol.17 , pp. 579-587
    • Gamboa-Dominguez, A.1    Dominguez-Fonseca, C.2    Quintanilla-Martinez, L.3
  • 13
    • 0037795412 scopus 로고    scopus 로고
    • Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer
    • PID: 12679307
    • García I, Vizoso F, Martín A et al (2003) Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer. Ann Surg Oncol 10:234–241. doi:10.1245/ASO.2003.05.010
    • (2003) Ann Surg Oncol , vol.10 , pp. 234-241
    • García, I.1    Vizoso, F.2    Martín, A.3
  • 14
    • 84555202718 scopus 로고    scopus 로고
    • Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer
    • COI: 1:CAS:528:DC%2BC38Xhslygs74%3D, PID: 22042954
    • Graziano F, Galluccio N, Lorenzini P et al (2011) Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer. J Clin Oncol 29:4789–4795. doi:10.1200/JCO.2011.36.7706
    • (2011) J Clin Oncol , vol.29 , pp. 4789-4795
    • Graziano, F.1    Galluccio, N.2    Lorenzini, P.3
  • 15
    • 84873141433 scopus 로고    scopus 로고
    • High MET gene copy number predicted poor prognosis in primary intestinal diffuse large B-cell lymphoma
    • PID: 23379953
    • Huang W-T, Chuang S-S (2013) High MET gene copy number predicted poor prognosis in primary intestinal diffuse large B-cell lymphoma. Diagn Pathol 8:16. doi:10.1186/1746-1596-8-16
    • (2013) Diagn Pathol , vol.8 , pp. 16
    • Huang, W.-T.1    Chuang, S.-S.2
  • 16
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • PID: 21296855
    • Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61:69–90. doi:10.3322/caac.20107
    • (2011) CA Cancer J Clin , vol.61 , pp. 69-90
    • Jemal, A.1    Bray, F.2    Center, M.M.3
  • 17
    • 0242694432 scopus 로고    scopus 로고
    • Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients
    • COI: 1:CAS:528:DC%2BD3sXovVOnsrg%3D, PID: 14614020
    • Junttila TT, Laato M, Vahlberg T et al (2003) Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Clin Cancer Res 9:5346–5357
    • (2003) Clin Cancer Res , vol.9 , pp. 5346-5357
    • Junttila, T.T.1    Laato, M.2    Vahlberg, T.3
  • 18
    • 84874605065 scopus 로고    scopus 로고
    • Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXmt1enu74%3D, PID: 23426935
    • Kato H, Arao T, Matsumoto K et al (2013) Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma. Int J Oncol 42:1151–1158. doi:10.3892/ijo.2013.1830
    • (2013) Int J Oncol , vol.42 , pp. 1151-1158
    • Kato, H.1    Arao, T.2    Matsumoto, K.3
  • 19
    • 84875796932 scopus 로고    scopus 로고
    • MET amplification as a potential therapeutic target in gastric cancer
    • PID: 23327903
    • Kawakami H, Okamoto I, Arao T et al (2013) MET amplification as a potential therapeutic target in gastric cancer. Oncotarget 4:9–17
    • (2013) Oncotarget , vol.4 , pp. 9-17
    • Kawakami, H.1    Okamoto, I.2    Arao, T.3
  • 20
    • 42649133793 scopus 로고    scopus 로고
    • EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number
    • COI: 1:CAS:528:DC%2BD1cXks1Wht70%3D, PID: 18397279
    • Kim MA, Lee HS, Lee HE et al (2008) EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number. Histopathology 52:738–746. doi:10.1111/j.1365-2559.2008.03021.x
    • (2008) Histopathology , vol.52 , pp. 738-746
    • Kim, M.A.1    Lee, H.S.2    Lee, H.E.3
  • 21
    • 61749089272 scopus 로고    scopus 로고
    • Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival
    • COI: 1:CAS:528:DC%2BD1MXisFensLw%3D, PID: 19259093
    • Kim J-S, Kim M-A, Kim TM et al (2009) Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival. Br J Cancer 100:732–738. doi:10.1038/sj.bjc.6604936
    • (2009) Br J Cancer , vol.100 , pp. 732-738
    • Kim, J.-S.1    Kim, M.-A.2    Kim, T.M.3
  • 22
    • 0027204267 scopus 로고
    • Aberrant expression of c-met mRNA in human gastric carcinomas
    • COI: 1:CAS:528:DyaK2cXhs1ShsbY%3D, PID: 8344755
    • Kuniyasu H, Yasui W, Yokozaki H et al (1993) Aberrant expression of c-met mRNA in human gastric carcinomas. Int J Cancer 55:72–75
    • (1993) Int J Cancer , vol.55 , pp. 72-75
    • Kuniyasu, H.1    Yasui, W.2    Yokozaki, H.3
  • 23
    • 0034641890 scopus 로고    scopus 로고
    • A novel germ line juxtamembrane Met mutation in human gastric cancer
    • COI: 1:CAS:528:DC%2BD3cXnslGqsbo%3D, PID: 11042681
    • Lee JH, Han SU, Cho H et al (2000) A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene 19:4947–4953
    • (2000) Oncogene , vol.19 , pp. 4947-4953
    • Lee, J.H.1    Han, S.U.2    Cho, H.3
  • 24
    • 79954471845 scopus 로고    scopus 로고
    • Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target
    • COI: 1:CAS:528:DC%2BC3MXnsVWhsbk%3D, PID: 21424128
    • Lee J, Seo JW, Jun HJ et al (2011) Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target. Oncol Rep 25:1517–1524. doi:10.3892/or.2011.1219
    • (2011) Oncol Rep , vol.25 , pp. 1517-1524
    • Lee, J.1    Seo, J.W.2    Jun, H.J.3
  • 25
    • 84863719409 scopus 로고    scopus 로고
    • MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome
    • COI: 1:CAS:528:DC%2BC38XhtVelsL%2FO, PID: 22644302
    • Lee HE, Kim MA, Lee HS et al (2012) MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome. Br J Cancer 107:325–333. doi:10.1038/bjc.2012.237
    • (2012) Br J Cancer , vol.107 , pp. 325-333
    • Lee, H.E.1    Kim, M.A.2    Lee, H.S.3
  • 26
    • 38049177080 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients
    • PID: 17896140
    • Lieto E, Ferraraccio F, Orditura M et al (2008) Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) is an independent prognostic indicator of worse outcome in gastric cancer patients. Ann Surg Oncol 15:69–79. doi:10.1245/s10434-007-9596-0
    • (2008) Ann Surg Oncol , vol.15 , pp. 69-79
    • Lieto, E.1    Ferraraccio, F.2    Orditura, M.3
  • 27
    • 73449111266 scopus 로고    scopus 로고
    • Developing c-MET pathway inhibitors for cancer therapy: progress and challenges
    • COI: 1:CAS:528:DC%2BC3cXjslCnug%3D%3D, PID: 20031486
    • Liu X, Newton RC, Scherle PA (2010) Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med 16:37–45. doi:10.1016/j.molmed.2009.11.005
    • (2010) Trends Mol Med , vol.16 , pp. 37-45
    • Liu, X.1    Newton, R.C.2    Scherle, P.A.3
  • 28
    • 46249131607 scopus 로고    scopus 로고
    • Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer
    • COI: 1:CAS:528:DC%2BD1cXnvFSjsLo%3D, PID: 18544998
    • Matsubara J, Yamada Y, Nakajima TE et al (2008) Clinical significance of insulin-like growth factor type 1 receptor and epidermal growth factor receptor in patients with advanced gastric cancer. Oncology 74:76–83. doi:10.1159/000139127
    • (2008) Oncology , vol.74 , pp. 76-83
    • Matsubara, J.1    Yamada, Y.2    Nakajima, T.E.3
  • 29
    • 84856829698 scopus 로고    scopus 로고
    • FGFR2 gene amplification and clinicopathological features in gastric cancer
    • COI: 1:CAS:528:DC%2BC38XisVGqtLo%3D, PID: 22240789
    • Matsumoto K, Arao T, Hamaguchi T et al (2012) FGFR2 gene amplification and clinicopathological features in gastric cancer. Br J Cancer 106:727–732. doi:10.1038/bjc.2011.603
    • (2012) Br J Cancer , vol.106 , pp. 727-732
    • Matsumoto, K.1    Arao, T.2    Hamaguchi, T.3
  • 30
    • 0033135820 scopus 로고    scopus 로고
    • The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas
    • COI: 1:CAS:528:DyaK1MXjtVCqsro%3D, PID: 10223227
    • Nakajima M, Sawada H, Yamada Y et al (1999) The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer 85:1894–1902
    • (1999) Cancer , vol.85 , pp. 1894-1902
    • Nakajima, M.1    Sawada, H.2    Yamada, Y.3
  • 31
    • 0034015241 scopus 로고    scopus 로고
    • Absence of mutations in the kinase domain of the Met gene and frequent expression of Met and HGF/SF protein in primary gastric carcinomas
    • COI: 1:CAS:528:DC%2BD3cXisVSlt7k%3D, PID: 10752688
    • Park WS, Oh RR, Kim YS et al (2000) Absence of mutations in the kinase domain of the Met gene and frequent expression of Met and HGF/SF protein in primary gastric carcinomas. Apmis 108:195–200
    • (2000) Apmis , vol.108 , pp. 195-200
    • Park, W.S.1    Oh, R.R.2    Kim, Y.S.3
  • 32
    • 0023019645 scopus 로고
    • Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas
    • COI: 1:CAS:528:DyaL28Xmt1ektbw%3D, PID: 3464796
    • Sakai K, Mori S, Kawamoto T et al (1986) Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas. J Natl Cancer Inst 77:1047–1052. doi:10.1093/jnci/77.5.1047
    • (1986) J Natl Cancer Inst , vol.77 , pp. 1047-1052
    • Sakai, K.1    Mori, S.2    Kawamoto, T.3
  • 33
    • 0029122417 scopus 로고
    • Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer
    • COI: 1:STN:280:DyaK2Mzptlelug%3D%3D, PID: 7664243
    • Seruca R, Suijkerbuijk RF, Gärtner F et al (1995) Increasing levels of MYC and MET co-amplification during tumor progression of a case of gastric cancer. Cancer Genet Cytogenet 82:140–145. doi:10.1016/0165-4608(95)00033-L
    • (1995) Cancer Genet Cytogenet , vol.82 , pp. 140-145
    • Seruca, R.1    Suijkerbuijk, R.F.2    Gärtner, F.3
  • 34
    • 78650704114 scopus 로고    scopus 로고
    • Prognostic significance of immunohistochemical expression of EGFR and C-erbB-2 oncoprotein in curatively resected gastric cancer
    • PID: 20368841
    • Song HS, Do YR, Kim IH et al (2004) Prognostic significance of immunohistochemical expression of EGFR and C-erbB-2 oncoprotein in curatively resected gastric cancer. Cancer Res Treat 36:240–245. doi:10.4143/crt.2004.36.4.240
    • (2004) Cancer Res Treat , vol.36 , pp. 240-245
    • Song, H.S.1    Do, Y.R.2    Kim, I.H.3
  • 35
    • 63749109364 scopus 로고    scopus 로고
    • Linking somatic genetic alterations in cancer to therapeutics
    • COI: 1:CAS:528:DC%2BD1MXksVCksro%3D, PID: 19328671
    • Stuart D, Sellers WR (2009) Linking somatic genetic alterations in cancer to therapeutics. Curr Opin Cell Biol 21:304–310. doi:10.1016/j.ceb.2009.02.001
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 304-310
    • Stuart, D.1    Sellers, W.R.2
  • 36
    • 0028960496 scopus 로고
    • Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis
    • COI: 1:STN:280:DyaK2M7ps1Wmug%3D%3D, PID: 7889467
    • Tahara E (1995) Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis. Cancer 75:1410–1417
    • (1995) Cancer , vol.75 , pp. 1410-1417
    • Tahara, E.1
  • 37
    • 34249783442 scopus 로고    scopus 로고
    • AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
    • COI: 1:CAS:528:DC%2BD2sXlt1KrtLs%3D, PID: 17505008
    • Takeda M, Arao T, Yokote H et al (2007) AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin Cancer Res 13:3051–3057. doi:10.1158/1078-0432.CCR-06-2743
    • (2007) Clin Cancer Res , vol.13 , pp. 3051-3057
    • Takeda, M.1    Arao, T.2    Yokote, H.3
  • 38
    • 0030668305 scopus 로고    scopus 로고
    • Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer
    • COI: 1:CAS:528:DyaK2sXnsVOqsr4%3D, PID: 9428926
    • Tsujimoto H, Sugihara H, Hagiwara A, Hattori T (1997) Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer. Virchows Arch 431:383–389. doi:10.1007/s004280050115
    • (1997) Virchows Arch , vol.431 , pp. 383-389
    • Tsujimoto, H.1    Sugihara, H.2    Hagiwara, A.3    Hattori, T.4
  • 39
    • 33750949065 scopus 로고    scopus 로고
    • Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group
    • PID: 17075117
    • Van Cutsem E, Moiseyenko VM, Tjulandin S et al (2006) Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol 24:4991–4997. doi:10.1200/JCO.2006.06.8429
    • (2006) J Clin Oncol , vol.24 , pp. 4991-4997
    • Van Cutsem, E.1    Moiseyenko, V.M.2    Tjulandin, S.3
  • 40
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • COI: 1:CAS:528:DC%2BD38XhsVGmt7o%3D, PID: 11821453
    • Vogel CL, Cobleigh MA, Tripathy D et al (2002) Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20:719–726. doi:10.1200/JCO.20.3.719
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 41
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • COI: 1:CAS:528:DC%2BD3MXivVWnt7k%3D, PID: 11252954
    • Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2:127–137. doi:10.1038/35052073
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 42
    • 79960792681 scopus 로고    scopus 로고
    • Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization
    • PID: 21689422
    • Yk W, Gao CF, Yun T et al (2011) Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization. Mol Cytogenet 4:14. doi:10.1186/1755-8166-4-14
    • (2011) Mol Cytogenet , vol.4 , pp. 14
    • Yk, W.1    Gao, C.F.2    Yun, T.3


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