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Volumn 36, Issue 1, 2016, Pages 132-142

Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons

Author keywords

Ambulatory blood pressure; cerebral small vessel disease (SVD); cognitive function; mobility; systolic hypertension; white matter hyperintensity lesions

Indexed keywords

BIOLOGICAL MARKER; HOMOCYSTEINE; LIPOPROTEIN; VON WILLEBRAND FACTOR;

EID: 84951568899     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.121     Document Type: Review
Times cited : (112)

References (70)
  • 1
    • 9444268676 scopus 로고    scopus 로고
    • Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study
    • Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996; 27: 1274-1282
    • (1996) Stroke , vol.27 , pp. 1274-1282
    • Longstreth, W.T.1    Manolio, T.A.2    Arnold, A.3    Burke, G.L.4    Bryan, N.5    Jungreis, C.A.6
  • 2
    • 0029034159 scopus 로고
    • White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home
    • Yikoski A, Erkinjuntti T, Raininko R, Sarna S, Sulkava R and Tilvis R. White matter hyperintensities on MRI in the neurologically nondiseased elderly. Analysis of cohorts of consecutive subjects aged 55 to 85 years living at home. Stroke 1995; 26: 1171-1177
    • (1995) Stroke , vol.26 , pp. 1171-1177
    • Yikoski, A.1    Erkinjuntti, T.2    Raininko, R.3    Sarna, S.4    Sulkava, R.5    Tilvis, R.6
  • 3
    • 77953533246 scopus 로고    scopus 로고
    • Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges
    • Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 2010; 9: 689-701
    • (2010) Lancet Neurol , vol.9 , pp. 689-701
    • Pantoni, L.1
  • 6
    • 0036215982 scopus 로고    scopus 로고
    • Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities
    • Marstrand JR, Garde E, Rostrup E, Ring P, Rosenbaum S, Mortensen EL, et al. Cerebral perfusion and cerebrovascular reactivity are reduced in white matter hyperintensities. Stroke 2002; 33: 972-976
    • (2002) Stroke , vol.33 , pp. 972-976
    • Marstrand, J.R.1    Garde, E.2    Rostrup, E.3    Ring, P.4    Rosenbaum, S.5    Mortensen, E.L.6
  • 7
    • 84880391350 scopus 로고    scopus 로고
    • Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    • Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013; 12: 822-828
    • (2013) Lancet Neurol , vol.12 , pp. 822-828
    • Wardlaw, J.M.1    Smith, E.E.2    Biessels, G.J.3    Cordonnier, C.4    Fazekas, F.5    Frayne, R.6
  • 8
    • 84886018695 scopus 로고    scopus 로고
    • Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons
    • Wolfson L, Wakefield DB, Moscufo N, Kaplan RF, Hall CB, Schmidt JA, et al. Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons. J Gerontol A Biol Sci Med Sci 2013; 68: 1387-1394
    • (2013) J Gerontol A Biol Sci Med Sci , vol.68 , pp. 1387-1394
    • Wolfson, L.1    Wakefield, D.B.2    Moscufo, N.3    Kaplan, R.F.4    Hall, C.B.5    Schmidt, J.A.6
  • 9
    • 24344482925 scopus 로고    scopus 로고
    • Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    • Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Jolles J, Koudstaal PJ, et al. Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain 2005; 128: 2034-2041
    • (2005) Brain , vol.128 , pp. 2034-2041
    • Prins, N.D.1    Van Dijk, E.J.2    Den Heijer, T.3    Vermeer, S.E.4    Jolles, J.5    Koudstaal, P.J.6
  • 10
    • 84866097416 scopus 로고    scopus 로고
    • Brain white matter hyperintensities, executive dysfunction, instability, and falls in older people: A prospective cohort study
    • Zheng JJ, Lord SR, Close JC, Sachdev PS, Wen W, Brodaty H, et al. Brain white matter hyperintensities, executive dysfunction, instability, and falls in older people: a prospective cohort study. J Gerontol A Biol Sci Med Sci 2012; 67: 1085-1091
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 1085-1091
    • Zheng, J.J.1    Lord, S.R.2    Close, J.C.3    Sachdev, P.S.4    Wen, W.5    Brodaty, H.6
  • 11
    • 77950271941 scopus 로고    scopus 로고
    • Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: The Framingham Offspring Study
    • Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, et al. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke 2010; 41: 600-606
    • (2010) Stroke , vol.41 , pp. 600-606
    • Debette, S.1    Beiser, A.2    DeCarli, C.3    Au, R.4    Himali, J.J.5    Kelly-Hayes, M.6
  • 12
    • 0031910347 scopus 로고    scopus 로고
    • Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
    • Kuller LH, Shemanski L, Manolio T, Haan M, Fried L, Bryan N, et al. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke 1998; 29: 388-398
    • (1998) Stroke , vol.29 , pp. 388-398
    • Kuller, L.H.1    Shemanski, L.2    Manolio, T.3    Haan, M.4    Fried, L.5    Bryan, N.6
  • 13
    • 38349048522 scopus 로고    scopus 로고
    • Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    • Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, et al. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol 2008; 65: 94-100
    • (2008) Arch Neurol , vol.65 , pp. 94-100
    • Smith, E.E.1    Egorova, S.2    Blacker, D.3    Killiany, R.J.4    Muzikansky, A.5    Dickerson, B.C.6
  • 14
    • 68149174856 scopus 로고    scopus 로고
    • Cognitive impairment risk: White matter hyperintensity progression matters
    • Silvert LC, Howieson DB, Dodge H and Kaye JA. Cognitive impairment risk: white matter hyperintensity progression matters. Neurology 2009; 73: 120-125
    • (2009) Neurology , vol.73 , pp. 120-125
    • Silvert, L.C.1    Howieson, D.B.2    Dodge, H.3    Kaye, J.A.4
  • 15
    • 8644231001 scopus 로고    scopus 로고
    • White matter lesions, cognition, and recurrent hemorrahage in lobar intracerebral hemorrhage
    • Smith EE, Gurol ME, Eng JA, Engel CR, Nguyen TN and Rosand J. White matter lesions, cognition, and recurrent hemorrahage in lobar intracerebral hemorrhage. Neurology 2004; 63: 1606-1612
    • (2004) Neurology , vol.63 , pp. 1606-1612
    • Smith, E.E.1    Gurol, M.E.2    Eng, J.A.3    Engel, C.R.4    Nguyen, T.N.5    Rosand, J.6
  • 16
    • 66849126212 scopus 로고    scopus 로고
    • Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history
    • Dufouil C, Godin O, Chalmers J, Coskun O, MacMahon S, Tzourio-Mazoyer N, et al. Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history. Stroke 2009; 40: 2219-2221
    • (2009) Stroke , vol.40 , pp. 2219-2221
    • Dufouil, C.1    Godin, O.2    Chalmers, J.3    Coskun, O.4    MacMahon, S.5    Tzourio-Mazoyer, N.6
  • 18
    • 34548222363 scopus 로고    scopus 로고
    • Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment
    • Debette S, Bombois S, Bruandet A, Delbeuck X, Lepoittevin S, Delmaire C, et al. Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment. Stroke 2007; 38: 2924-2930
    • (2007) Stroke , vol.38 , pp. 2924-2930
    • Debette, S.1    Bombois, S.2    Bruandet, A.3    Delbeuck, X.4    Lepoittevin, S.5    Delmaire, C.6
  • 19
    • 70350550190 scopus 로고    scopus 로고
    • Subjective cognitive complaints relate to white matter hyperintensities and future cognitive decline in patients with cardiovascular disease
    • Haley AP, Hoth KF, Gunstad J, Paul RH, Jefferson AL, Tate DF, et al. Subjective cognitive complaints relate to white matter hyperintensities and future cognitive decline in patients with cardiovascular disease. Am J Geriatr Psychiatry 2009; 17: 976-985
    • (2009) Am J Geriatr Psychiatry , vol.17 , pp. 976-985
    • Haley, A.P.1    Hoth, K.F.2    Gunstad, J.3    Paul, R.H.4    Jefferson, A.L.5    Tate, D.F.6
  • 20
    • 77955360281 scopus 로고    scopus 로고
    • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis
    • Debette S and Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010; 341: c3666
    • (2010) BMJ , vol.341 , pp. c3666
    • Debette, S.1    Markus, H.S.2
  • 21
    • 41149085551 scopus 로고    scopus 로고
    • Association of gait and balance disorders with age-related white matter changes: The LADIS study
    • Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, et al. Association of gait and balance disorders with age-related white matter changes: the LADIS study. Neurology 2008; 70: 935-942
    • (2008) Neurology , vol.70 , pp. 935-942
    • Baezner, H.1    Blahak, C.2    Poggesi, A.3    Pantoni, L.4    Inzitari, D.5    Chabriat, H.6
  • 23
    • 0031778072 scopus 로고    scopus 로고
    • Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins
    • Carmelli D, DeCarli C, Swan GE, Jack LM, Reed T, Wolf PA, et al. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke 1998; 29: 1177-1181
    • (1998) Stroke , vol.29 , pp. 1177-1181
    • Carmelli, D.1    DeCarli, C.2    Swan, G.E.3    Jack, L.M.4    Reed, T.5    Wolf, P.A.6
  • 24
    • 77950273952 scopus 로고    scopus 로고
    • Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: Study in 200 consecutively recruited individuals
    • Adib-Samii P, Brice G, Martin RJ and Markus HS. Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: study in 200 consecutively recruited individuals. Stroke 2010; 41: 630-634
    • (2010) Stroke , vol.41 , pp. 630-634
    • Adib-Samii, P.1    Brice, G.2    Martin, R.J.3    Markus, H.S.4
  • 25
    • 81055147238 scopus 로고    scopus 로고
    • Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease
    • Schmidt H, Zeginigg M, Wiltgen M, Freudenberger P, Petrovic K, Cavalieri M, et al. Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease. Brain 2011; 134: 3384-3397
    • (2011) Brain , vol.134 , pp. 3384-3397
    • Schmidt, H.1    Zeginigg, M.2    Wiltgen, M.3    Freudenberger, P.4    Petrovic, K.5    Cavalieri, M.6
  • 26
    • 82955201843 scopus 로고    scopus 로고
    • Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: The Ohasama study
    • Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, et al. Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese: the Ohasama study. Hypertens Res 2011; 34: 1327-1332
    • (2011) Hypertens Res , vol.34 , pp. 1327-1332
    • Hirose, T.1    Totsune, K.2    Nakashige, Y.3    Metoki, H.4    Kikuya, M.5    Ohkubo, T.6
  • 27
    • 0034189590 scopus 로고    scopus 로고
    • Adrenomedullin: A vasoactive and natriuretic peptide with therapeutic potential
    • Lah JJ and Frishman WH. Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential. Heart Dis 2000; 2: 259-265
    • (2000) Heart Dis , vol.2 , pp. 259-265
    • Lah, J.J.1    Frishman, W.H.2
  • 28
    • 1342346545 scopus 로고    scopus 로고
    • Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complex
    • Roh J, Chang CL, Bhalla A, Klein C and Hsu SY. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complex. J Biol Chem 2004; 279: 7264-7274
    • (2004) J Biol Chem , vol.279 , pp. 7264-7274
    • Roh, J.1    Chang, C.L.2    Bhalla, A.3    Klein, C.4    Hsu, S.Y.5
  • 30
    • 84906990802 scopus 로고    scopus 로고
    • Renin-angiotensin system genetic polymorphisms and brain white matter lesions in older Australians
    • Assareh AA, Mather KA, Crawford JD, Wen W, Anstey KJ, Easteal S, et al. Renin-angiotensin system genetic polymorphisms and brain white matter lesions in older Australians. Am J Hypertens 2014; 27: 1191-1198
    • (2014) Am J Hypertens , vol.27 , pp. 1191-1198
    • Assareh, A.A.1    Mather, K.A.2    Crawford, J.D.3    Wen, W.4    Anstey, K.J.5    Easteal, S.6
  • 31
    • 0035571556 scopus 로고    scopus 로고
    • Angiotensinogen polymorphism M235T, carotid atherosclerosis, and smallvessel disease-related cerebral abnormalities
    • Schmidt R, Schmidt H, Fazekas F, Launer LJ, Niederkorn K, Kapeller P, et al. Angiotensinogen polymorphism M235T, carotid atherosclerosis, and smallvessel disease-related cerebral abnormalities. Hypertension 2001; 38: 110-115
    • (2001) Hypertension , vol.38 , pp. 110-115
    • Schmidt, R.1    Schmidt, H.2    Fazekas, F.3    Launer, L.J.4    Niederkorn, K.5    Kapeller, P.6
  • 32
    • 84923502372 scopus 로고    scopus 로고
    • Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of sodium glucose transporters SGLT1 and SGLT2, in Type 2 diabetes on metformin monotherapy
    • Rosenstock J, Cefalu WT, Lapuerta P, Zambrowicz B, Ogbaa I, Banks P, et al. Greater dose-ranging effects on A1C levels than on glucosuria with LX4211, a dual inhibitor of sodium glucose transporters SGLT1 and SGLT2, in Type 2 diabetes on metformin monotherapy. Diabetes Care 2014; 38: 431-438
    • (2014) Diabetes Care , vol.38 , pp. 431-438
    • Rosenstock, J.1    Cefalu, W.T.2    Lapuerta, P.3    Zambrowicz, B.4    Ogbaa, I.5    Banks, P.6
  • 33
    • 84906050670 scopus 로고    scopus 로고
    • Haptoglobin genotype and cerebrovascular disease incidence in type 1 diabetes
    • Costacou T, Secrest AM, Ferrell RE and Orchard TJ. Haptoglobin genotype and cerebrovascular disease incidence in type 1 diabetes. Diab Vasc Dis Res 2014; 11: 335-342
    • (2014) Diab Vasc Dis Res , vol.11 , pp. 335-342
    • Costacou, T.1    Secrest, A.M.2    Ferrell, R.E.3    Orchard, T.J.4
  • 34
    • 44449156820 scopus 로고    scopus 로고
    • Metabolic syndrome is associated with silent ischemic brain lesions
    • Bokura H, Yamaguchi S, Iijima K, Nagai A and Oguro H. Metabolic syndrome is associated with silent ischemic brain lesions. Stroke 2008; 39: 1607-1609
    • (2008) Stroke , vol.39 , pp. 1607-1609
    • Bokura, H.1    Yamaguchi, S.2    Iijima, K.3    Nagai, A.4    Oguro, H.5
  • 37
    • 84900790466 scopus 로고    scopus 로고
    • Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes
    • Sims RC, Katzel LI, Lefkowitz DM, Siegel EL, Rosenberger WF, Manukyan Z, et al. Association of fasting glucose with subclinical cerebrovascular disease in older adults without Type 2 diabetes. Diabet Med 2014; 31: 691-698
    • (2014) Diabet Med , vol.31 , pp. 691-698
    • Sims, R.C.1    Katzel, L.I.2    Lefkowitz, D.M.3    Siegel, E.L.4    Rosenberger, W.F.5    Manukyan, Z.6
  • 39
    • 33746462348 scopus 로고    scopus 로고
    • Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes
    • Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, et al. Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes. Diabetes Care 2006; 29: 1529-1534
    • (2006) Diabetes Care , vol.29 , pp. 1529-1534
    • Novak, V.1    Last, D.2    Alsop, D.C.3    Abduljalil, A.M.4    Hu, K.5    Lepicovsky, L.6
  • 41
    • 20444410004 scopus 로고    scopus 로고
    • Total homocysteine is associated with white matter hyperintensity volume: The Northern Manhattan Study
    • Wright CB, Paik MC, Brown TR, Stabler SP, Allen RH, Sacco RL, et al. Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke 2005; 36: 1207-1211
    • (2005) Stroke , vol.36 , pp. 1207-1211
    • Wright, C.B.1    Paik, M.C.2    Brown, T.R.3    Stabler, S.P.4    Allen, R.H.5    Sacco, R.L.6
  • 42
    • 0346097879 scopus 로고    scopus 로고
    • Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction
    • Hassan A, Hunt BJ, O'Sullivan M, Bell R, D'Souza R, Jeffrey S, et al. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 2004; 127: 212-219
    • (2004) Brain , vol.127 , pp. 212-219
    • Hassan, A.1    Hunt, B.J.2    O'Sullivan, M.3    Bell, R.4    D'Souza, R.5    Jeffrey, S.6
  • 43
    • 70350761559 scopus 로고    scopus 로고
    • Plasma level of sICAM-1 associated with extent of white matter lesion among asymptomatic elderly subjects
    • Han JH, Wong KS, Wang YY, Fu JH, Ding D and Hong Z. Plasma level of sICAM-1 associated with extent of white matter lesion among asymptomatic elderly subjects. Clin Neurol Neurosurg 2009; 111: 847-851
    • (2009) Clin Neurol Neurosurg , vol.111 , pp. 847-851
    • Han, J.H.1    Wong, K.S.2    Wang, Y.Y.3    Fu, J.H.4    Ding, D.5    Hong, Z.6
  • 44
    • 36549012177 scopus 로고    scopus 로고
    • Cerebral small vessel disease and C-reactive protein: Results of a cross-sectional study in community-based Japanese elderly
    • Wada M, Nagasawa H, Kurita K, Koyama S, Arawaka S, Kawanami T, et al. Cerebral small vessel disease and C-reactive protein: results of a cross-sectional study in community-based Japanese elderly. J Neurol Sci 2008; 264: 43-49
    • (2008) J Neurol Sci , vol.264 , pp. 43-49
    • Wada, M.1    Nagasawa, H.2    Kurita, K.3    Koyama, S.4    Arawaka, S.5    Kawanami, T.6
  • 45
    • 4444238225 scopus 로고    scopus 로고
    • Correlation of NO metabolites and 8-isoprostaglandin F2a with periventricular hyperintensity severity
    • Shibata H, Nabika T, Moriyama H, Masuda J and Kobayashi S. Correlation of NO metabolites and 8-isoprostaglandin F2a with periventricular hyperintensity severity. Arterioscler Thromb Vasc Biol 2004; 24: 1659-1663
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1659-1663
    • Shibata, H.1    Nabika, T.2    Moriyama, H.3    Masuda, J.4    Kobayashi, S.5
  • 46
    • 84866418794 scopus 로고    scopus 로고
    • Association of prothrombotic status with markers of cerebral small vessel disease in elderly hypertensive patients
    • Nagai M, Hoshide S and Kario K. Association of prothrombotic status with markers of cerebral small vessel disease in elderly hypertensive patients. Am J Hypertens 2012; 25: 1088-1094
    • (2012) Am J Hypertens , vol.25 , pp. 1088-1094
    • Nagai, M.1    Hoshide, S.2    Kario, K.3
  • 47
    • 0029864466 scopus 로고    scopus 로고
    • Cigarette smoking is correlated with the periventricular hyperintensity grade of brain magnetic resonance imaging
    • Fukuda H and Kitani M. Cigarette smoking is correlated with the periventricular hyperintensity grade of brain magnetic resonance imaging. Stroke 1996; 27: 645-649
    • (1996) Stroke , vol.27 , pp. 645-649
    • Fukuda, H.1    Kitani, M.2
  • 49
    • 0028036209 scopus 로고
    • Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study
    • Manolio TA, Kronmal RA, Burke GL, Poirier V, O'Leary DH, Gardin JM, et al. Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study. Stroke 1994; 25: 318-327
    • (1994) Stroke , vol.25 , pp. 318-327
    • Manolio, T.A.1    Kronmal, R.A.2    Burke, G.L.3    Poirier, V.4    O'Leary, D.H.5    Gardin, J.M.6
  • 50
    • 77649092348 scopus 로고    scopus 로고
    • Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke
    • Jimenez-Conde J, Biffi A, Rahman R, Kanakis A, Butler C, Sonni S, et al. Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke. Stroke 2010; 41: 437-442
    • (2010) Stroke , vol.41 , pp. 437-442
    • Jimenez-Conde, J.1    Biffi, A.2    Rahman, R.3    Kanakis, A.4    Butler, C.5    Sonni, S.6
  • 51
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • Dietschy JM and Turley SD. Cholesterol metabolism in the brain. Curr Opin Lipidol 2001; 12: 105-112
    • (2001) Curr Opin Lipidol , vol.12 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2
  • 54
    • 81855195913 scopus 로고    scopus 로고
    • Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people
    • White WB, Wolfson L, Wakefield DB, Hall CB, Campbell P, Moscufo N, et al. Average daily blood pressure, not office blood pressure, is associated with progression of cerebrovascular disease and cognitive decline in older people. Circulation 2011; 124: 2312-2319
    • (2011) Circulation , vol.124 , pp. 2312-2319
    • White, W.B.1    Wolfson, L.2    Wakefield, D.B.3    Hall, C.B.4    Campbell, P.5    Moscufo, N.6
  • 56
    • 48349106436 scopus 로고    scopus 로고
    • Microalbuminurea as an index of brain microvascular dysfunction
    • Wolfson L. Microalbuminurea as an index of brain microvascular dysfunction. J Neurol Sci 2008; 272: 34-35
    • (2008) J Neurol Sci , vol.272 , pp. 34-35
    • Wolfson, L.1
  • 57
    • 3242813907 scopus 로고    scopus 로고
    • White matter hyperintensity on cranial magnetic resonance imaging: A predictor of stroke
    • Kuller LH, Longstreth WT Jr, Arnold AM, Bernick C, Bryan RN, Beauchamp NJ Jr, et al. White matter hyperintensity on cranial magnetic resonance imaging: a predictor of stroke. Stroke 2004; 35: 1821-1825
    • (2004) Stroke , vol.35 , pp. 1821-1825
    • Kuller, L.H.1    Longstreth, W.T.2    Arnold, A.M.3    Bernick, C.4    Bryan, R.N.5    Beauchamp, N.J.6
  • 58
    • 58249126857 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
    • Rosenberg GA. Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol 2009; 8: 205-216
    • (2009) Lancet Neurol , vol.8 , pp. 205-216
    • Rosenberg, G.A.1
  • 59
    • 0037039231 scopus 로고    scopus 로고
    • Older people with impaired mobility have specific loci of periventricular abnormality on MRI
    • Benson RR, Guttmann CR, Wei X, Warfield SK, Hall C, Schmidt JA, et al. Older people with impaired mobility have specific loci of periventricular abnormality on MRI. Neurology 2002; 58: 48-55
    • (2002) Neurology , vol.58 , pp. 48-55
    • Benson, R.R.1    Guttmann, C.R.2    Wei, X.3    Warfield, S.K.4    Hall, C.5    Schmidt, J.A.6
  • 60
    • 0029084578 scopus 로고
    • White matter lesions and disequilibrium in older people. I. Case-control comparison
    • Baloh RW, Yue Q, Socotch TM and Jacobson KM. White matter lesions and disequilibrium in older people. I. Case-control comparison. Arch Neurol 1995; 52: 970-974
    • (1995) Arch Neurol , vol.52 , pp. 970-974
    • Baloh, R.W.1    Yue, Q.2    Socotch, T.M.3    Jacobson, K.M.4
  • 61
    • 0032827909 scopus 로고    scopus 로고
    • Urinary function in elderly people with and without leukoaraiosis: Relation to cognitive and gait function
    • Sakakibara R, Hattori T, Uchiyama T and Yamanishi T. Urinary function in elderly people with and without leukoaraiosis: relation to cognitive and gait function. J Neurol Neurosurg Psychiatry 1999; 67: 658-660
    • (1999) J Neurol Neurosurg Psychiatry , vol.67 , pp. 658-660
    • Sakakibara, R.1    Hattori, T.2    Uchiyama, T.3    Yamanishi, T.4
  • 62
    • 0025190459 scopus 로고
    • Leuko-araiosis on magnetic resonance imaging and speed of mental processing
    • JunquéC, Pujol J, Vendrell P, Bruna O, Jódar M, Ribas JC, et al. Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol 1990; 47: 151-156
    • (1990) Arch Neurol , vol.47 , pp. 151-156
    • Junquéc1    Pujol, J.2    Vendrell, P.3    Bruna, O.4    Jódar, M.5    Ribas, J.C.6
  • 63
  • 66
    • 84942303188 scopus 로고    scopus 로고
    • Mobility decline in the elderly relates to lesion accrual in the splenium of the corpus callosum
    • Moscufo N, Wolfson L, Meier D, Liguori M, Hildenbrand PG, Wakefield D, et al. Mobility decline in the elderly relates to lesion accrual in the splenium of the corpus callosum. Age (Dordr) 2012; 34: 405-414
    • (2012) Age (Dordr) , vol.34 , pp. 405-414
    • Moscufo, N.1    Wolfson, L.2    Meier, D.3    Liguori, M.4    Hildenbrand, P.G.5    Wakefield, D.6
  • 67
    • 77958047780 scopus 로고    scopus 로고
    • Long-term reproducibility of ambulatory blood pressure is superior to office blood pressure in the very elderly
    • Campbell P, Ghuman N, Wakefield D, Wolfson L and White WB. Long-term reproducibility of ambulatory blood pressure is superior to office blood pressure in the very elderly. J Hum Hypertens 2010; 24: 749-754
    • (2010) J Hum Hypertens , vol.24 , pp. 749-754
    • Campbell, P.1    Ghuman, N.2    Wakefield, D.3    Wolfson, L.4    White, W.B.5
  • 68
    • 0031943476 scopus 로고    scopus 로고
    • Nocturnal blood pressure epidemiology, determinants, and effects of antihypertensive therapy
    • White WB, Mansoor GA, Tendler BE and Anwar YA. Nocturnal blood pressure epidemiology, determinants, and effects of antihypertensive therapy. Blood Press Monit 1998; 3: 43-51
    • (1998) Blood Press Monit , vol.3 , pp. 43-51
    • White, W.B.1    Mansoor, G.A.2    Tendler, B.E.3    Anwar, Y.A.4
  • 69
    • 84875210977 scopus 로고    scopus 로고
    • Intensive versus standard ambulatory blood pressure lowering to prevent functional decline in the elderly (INFINITY)
    • White WB, Marfatia R, Schmidt J, Wakefield DB, Kaplan RW, Bohannon CB, et al. Intensive versus standard ambulatory blood pressure lowering to prevent functional decline in the elderly (INFINITY). Am Heart J 2013; 165: 258-265
    • (2013) Am Heart J , vol.165 , pp. 258-265
    • White, W.B.1    Marfatia, R.2    Schmidt, J.3    Wakefield, D.B.4    Kaplan, R.W.5    Bohannon, C.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.