Impact of weekly iron folic acid supplementation with and without vitamin B12 on anaemic adolescent girls: A randomised clinical trial

European Journal of Clinical Nutrition

Volumn 70, Issue 6, 2016, Pages 730-737

  Bansal, P G ^a   Toteja, G S ^a   Bhatia, N ^b   Vikram, N K ^c   Siddhu, A ^b  

^a INDIAN COUNCIL OF MEDICAL RESEARCH   (India)

^b UNIVERSITY OF DELHI   (India)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FERRITIN; FOLIC ACID; HEMOGLOBIN; IRON; PLACEBO;

ADOLESCENT; ANEMIA; ARTICLE; CHILD; COMMUNITY CARE; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; NUTRITIONAL STATUS; PREVALENCE; PROTEIN DEFICIENCY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; BLOOD; DEFICIENCY; DIET THERAPY; DIETARY SUPPLEMENT; INDIA; IRON DEFICIENCY ANEMIA;

ADOLESCENT; ANEMIA, IRON-DEFICIENCY; CHILD; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FERRITINS; FOLIC ACID; HEMOGLOBINS; HUMANS; INDIA; IRON; VITAMIN B 12;

EID: 84951311081     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2015.215     Document Type: Article

References (43)

1. UNICEF. Prevention and Nutritional Anaemia: A South Asia Priority United Nations Children's Fund. Regional Office for South Asia, 2002.
2. Toteja GS, Singh P, Dhillon BS, Saxena BN, Ahmed FU, Singh RP et al. Prevalence of anemia among pregnant women and adolescent girls in 16 districts of India. Food Nutr Bull 2006; 27: 311-315.
3. National Family Health Survey 3 India 2005-2006; International Institute of Population Sciences: Mumbai, India and ORC Macro, Calverton, MD, USA, 2007.
4. District Level Household Survey, 2007-2008. Available from http://www.rchindia. org/dlhs-india.htm. (accessed on 15 March 2014).
5. NNMB Technical Report No. 22. National Nutrition Monitoring Bureau (NNMB). Prevalence of Micronutrient Deficiencies. National Institute of Nutrition, Indian Council of Medical Research: Hyderabad, India, 2003.
6. NNMB Technical Report No. 24. National Nutrition Monitoring Bureau (NNMB). Prevalence of Micronutrient Deficiencies. National Institute of Nutrition, Indian Council of Medical Research: Hyderabad, India, 2006.
7. Guidelines for Iron Folic Acid Supplementation. Ministry of Health and Family Welfare, Government of India: India, 2007.
8. Guidelines for Control of Iron Deficiency Anaemia National Iron+Initiative. Adolescent Division, Ministry of Health and Family Welfare, Government of India: India, 2013. Available from: http://www.unicef.org/india/10.National-Iron-Plus-Initiative-Guidelines-for-Control-of-IDA.pdf.
9. Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr 2000; 3: 125-150.
10. Chanarin I, Deacon R, Lumb M, Perry J. Cobalamin-folate interrelations. Blood Rev 1989; 3: 211-215.
11. Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP. Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the women's health and aging study. Am J Psychiatry 2000; 157: 715-721.
12. Spray GH, Witts LJ. The utilization of folic acid given by mouth. Clin Sci 1952; 3: 273-281.
13. Cox EV, Meynell MJ, Cooke WT, Gaddie R. Folic acid and cyanocobalamin in pernicious anaemia. Clin Sci 1958; 17: 693-699.
14. Watanabe F. Vitamin B12 sources and bioavailability. Exp Biol Med 2007; 232: 1266-1274.
15. Allen LH. Iron supplements: Scientific issues concerning efficacy and implications for research and programs. J Nutr 2002; 132: 813S-819S.
16. Zwart A, van Assendelft OW, Bull BS, England JM, Lewis SM, Zijlstra WG. ICSH Recommendations for reference method for hemoglobinometry in human blood (ICSH standards 1995) and specifications for international hemoglobincyanamyde standard. J Clin Pathol 1996; 49: 271-274.
17. WHO. Worldwide prevalence of anaemia: 1993-2005. WHO Global Database on Anaemia, 2008. Available from http://whqlibdoc.who.int/publications/2008/9789241596657-eng.pdf.
18. Kotecha PV, Nirupam S, Karkar PD. Adolescent girls' anaemia control programme, Gujarat, India. Indian J Med Res 2009; 130: 584-589.
19. Deshmukh PR, Garg BS, Bharambe MS. Effectiveness of weekly supplementation of Iron to control anaemia among adolescent girls of Nashik, Maharashtra, India. J Health Popul Nutr 2008; 26: 74-78.
20. Vir SC, Singh N, Nigam AK, Jain R. Weekly iron and folic acid supplementation with counseling reduces anemia in adolescent girls: a large-scale effectiveness study in Uttar Pradesh, India. Food Nutr Bull 2008; 29: 186-194.
21. Chakma T, Vinay Rao P, Meshram PK. Factors associated with high compliance/feasibility during iron and folic acid supplementation in a tribal area of Madhya Pradesh, India. Public Health Nutr 2012; 28: 1-4.
22. Dongre AR, Deshmukh PR, Garg BS. Community-led initiative for control of anemia among children 6 to 35 months of age and unmarried adolescent girls in rural Wardha, India. Food Nutr Bull 2011; 32: 315-323.
23. Patel BH, Saxena D, Singhal D, Sharma VK, Maheshwari RS, Prakash MM. Intervention of iron-folic acid in school children J Hum Ecol 2009; 25: 61-62.
24. Agarwal KN, Gomber S, Bisht H, Som M. Anemia prophylaxis in adolescent school girls by weekly or daily. Indian Pediatr 2003; 40: 296-301.
25. Shobha S, Sharda D. Efficacy of twice weekly iron supplementation in anaemic adolescent girls. Indian Pediatr 2003; 40: 1186-1190.
26. Joshi M, Gumashta R. Weekly iron folate supplementation in adolescent girls-an effective nutritional measure for the management of iron deficiency anaemia. Glob J Health Sci 2013; 5: 188-194.
27. Casey GJ, Phuc TQ, MacGregor L, Montresor A, Mihrshahi S, Thach TD et al. A free weekly iron-folic acid supplementation and regular deworming program is associated with improved hemoglobin and iron status indicators in Vietnamese women. BMC Public Health 2009; 9: 261-268.
28. Tee ES, Kandiah M, Awin N, Chong SM, Satgunasingam N, Kamarudin L et al. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls. Am J Clin Nutr 1999; 69: 1249-1256.
29. Cairo G, Ronchi R, Buccellato FR, Veber D, Santambrogio P, Scalabrino G. Regulation of the ferritin H subunit by vitamin B12 (cobalamin) in rat spinal cord. J Neurosci Res 2002; 69: 117-124.
30. Duggan C, Srinivasan K, Thomas T, Samuel T, Rajendran R, Muthayya S et al. Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J Nutr 2014; 144: 758-764.
31. Shahab-Ferdows S, Anaya-Loyola MA, Vergara-Castañeda H, Rosado JL, Keyes WR, Newman JW et al. Vitamin B-12 supplementation of rural Mexican women changes biochemical vitamin B-12 status indicators but does not affect hematology or a bone turnover marker. J Nutr 2012; 142: 1881-1887.
32. Iyengar L, Apte SV. Prophylaxis of anaemia in pregnancy. Am J Clin Nutr 1970; 23: 725-730.
33. Basu RN, Sood SK, Ramachandran K, Mathur M, Ramalingaswami V. Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach. Am J Clin Nutr 1973; 26: 591-594.
34. Sood SK, Ramachandran K, Mathur M, Gupta K, Ramalingaswamy V, Swarnabai C et al. The effects of supplemental oral iron administration to pregnant women. Q J Med 1975; 44: 241-258.
35. Reid ED, Lopez P, Galaviz IA, Isoard F, Rosado JL, Allen LH. Hematological and biochemical responses of rural Mexican preschoolers to iron alone or iron plus micronutrients. FASEB J 2001; 15: A731 (abstract).
36. Chandelia S, Chandra J, Narayan S, Aneja S, Chawla HM, Sharma S et al. Addition of cobalamin to iron and folic acid improves hemoglobin rise in nutritional anemia. Indian J Pediatrics 2010; 12: 1592-1596.
37. Green R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr 2011; 94: 666S-672S.
38. Klee GG. Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B12 and folate. Clin Chem 2000; 46: 1277-1283.
39. Yetley EA, Pfeiffer CM, Phinney KW, Bailey RL, Blackmore S, Bock JL et al. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011; 94: 3135-3215.
40. Green R. Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies. Food Nutr Bull 2008; 29: S52-S63.
41. Yetley EA, Pfeiffer CM, Phinney KW, Fazili Z, Lacher DA, Bailey RL et al. Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr 2011; 94: 303S-312S.
42. WHO. Iron Deficiency Anaemia Assessment, Prevention, and Control. A guide for programme managers, 2001. WHO/NHD/01.3.
43. de Benoist B. WHO: Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008; 29: S238-S244.