Contribution of β-cell dysfunction and insulin resistance to cirrhosis-associated diabetes: Role of severity of liver disease

Journal of Hepatology

Volumn 63, Issue 6, 2015, Pages 1484-1490

  Grancini, Valeria ^a   Trombetta, Maddalena ^b   Lunati, Maria Elena ^a   Zimbalatti, Dario ^a   Boselli, Maria Linda ^b   Gatti, Stefano ^a   Donato, Maria Francesca ^a   Resi, Veronica ^a   D'Ambrosio, Roberta ^a   Aghemo, Alessio ^a   Pugliese, Giuseppe ^c   Bonadonna, Riccardo C ^d   Orsi, Emanuela ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

Author keywords

Child Pugh classification; Diabetes mellitus; Insulin resistance; Liver cirrhosis; Cell dysfunction

Indexed keywords

GLUCOSE; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BETA CELL DYSFUNCTION; CELL FUNCTION; CHILD PUGH SCORE; CLINICAL EVALUATION; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NON INVASIVE PROCEDURE; ORAL GLUCOSE TOLERANCE TEST; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; CHRONIC HEPATITIS C; COMPLICATION; CROSS-SECTIONAL STUDY; DIABETES COMPLICATIONS; GLUCOSE TOLERANCE TEST; LIVER TRANSPLANTATION; METABOLISM; MIDDLE AGED; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; SEVERITY OF ILLNESS INDEX;

BLOOD GLUCOSE; CROSS-SECTIONAL STUDIES; DIABETES COMPLICATIONS; FEMALE; GLUCOSE TOLERANCE TEST; HEPATITIS C, CHRONIC; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 84951103456     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.08.011     Document Type: Article

References (32)

1. C. Megyesi, E. Samols, and V. Marks Glucose tolerance and diabetes in chronic liver disease Lancet 2 1967 1051 1056
2. D. Garcia-Compean, J.O. Jaquez-Quintana, J.A. Gonzalez-Gonzalez, and H. Maldonado-Garza Liver cirrhosis and diabetes: risk factors, pathophysiology, clinical implications and management World J Gastroenterol 15 2009 280 288
3. S. Moscatiello, R. Manini, and G. Marchesini Diabetes and liver disease: an ominous association Nutr Metab Cardiovasc Dis 17 2007 63 70
4. A. Lecube, C. Hernández, J. Genescà, and R. Simó Glucose abnormalities in patients with hepatitis C virus infection: epidemiology and pathogenesis Diabetes Care 29 2006 1140 1149
5. T. Kawaguchi, E. Taniguchi, M. Itou, M. Sakata, S. Sumie, and M. Sata Insulin resistance and chronic liver disease World J Hepatol 3 2011 99 107
6. E. Imano, T. Nishida, M. Shibata, and T. Kanda Significance of oral glucose tolerance test for the diagnosis of diabetes mellitus in patients with liver cirrhosis Intern Med 38 1999 918
7. A. Holstein, S. Hinze, E. Thiessen, A. Plaschke, and E.H. Egberts Clinical implications of hepatogenous diabetes in liver cirrhosis J Gastroenterol Hepatol 17 2002 677 681
8. E. Shmueli, M. Walker, G. Alberti, and C.O. Record Normal splanchnic but impaired peripheral insulin-stimulated glucose uptake in cirrhosis Hepatology 18 1993 86 95
9. A.S. Petrides, C. Vogt, D. Schulze-Berge, D. Matthews, and G. Strohmeyer Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis Hepatology 19 1994 616 627
10. G. Perseghin, V. Mazzaferro, L.P. Sereni, E. Regalia, S. Benedini, E. Bazzigaluppi, and et al. Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation Hepatology 31 2000 694 703
11. G. Marchesini, G. Pacini, G. Bianchi, D. Patrono, and C. Cobelli Glucose disposal, beta-cell secretion, and hepatic insulin extraction in cirrhosis: a minimal model assessment Gastroenterology 99 1990 1715 1722
12. Y.T. Kruszynska, S. Goulas, N. Wollen, and N. McIntyre Insulin secretory capacity and the regulation of glucagon secretion in diabetic and non-diabetic alcoholic cirrhotic patients J Hepatol 28 1998 280 291
13. K.F. Murray, R.L. Carithers Jr AASLD AASLD practice guidelines: evaluation of the patient for liver transplantation Hepatology 41 2005 1407 1432
14. US Department of Health and Human Services. National Center for Health Statistics. NHANES III reference manuals and reports (CDROM) 1996 Centers for Disease Control and Prevention Hyattsville, MD
15. M. Pirlich, T. Schütz, T. Spachos, S. Ertl, M.L. Weiss, H. Lochs, and et al. Bioelectrical impedance analysis is a useful bedside technique to assess malnutrition in cirrhotic patients with and without ascites Hepatology 32 2000 1208 1215
16. F. Durand, and D. Valla Assessment of the prognosis of cirrhosis: Child-Pugh versus MELD J Hepatol 42 2005 S100 S107
17. R. Wiesner, E. Edwards, R. Freeman, A. Harper, R. Kim, P. Kamath, and et al. Model for end-stage liver disease (MELD) and allocation of donor livers Gastroenterology 124 2003 91 96
18. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 33 2010 S62 S69
19. R.C. Bonadonna, T. Heise, C. Arbet-Engels, C. Kapitza, A. Avogaro, J. Grimsby, and et al. Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study J Clin Endocrinol Metab 95 2010 5028 5036
20. A. Mari, G. Pacini, E. Murphy, B. Ludvik, and J.J. Nolan A model-based method for assessing insulin sensitivity from the oral glucose tolerance test Diabetes Care 24 2001 539 548
21. C. Cobelli, G.M. Toffolo, C. Dalla Man, M. Campioni, P. Denti, A. Caumo, and et al. Assessment of beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests Am J Physiol Endocrinol Metab 293 2007 E1 E15
22. A. Mari, S. Camastra, E. Toschi, A. Giancaterini, A. Gastaldelli, G. Mingrone, and et al. A model for glucose control of insulin secretion during 24 h of free living Diabetes 50 2001 S164 S168
23. M.E. Lunati, V. Grancini, F. Agnelli, S. Gatti, B. Masserini, D. Zimbalatti, and et al. Metabolic syndrome after liver transplantation: short-term prevalence and pre- and post-operative risk factors Dig Liver Dis 45 2013 833 839
24. T. Nishida, S. Tsuji, M. Tsujii, S. Arimitsu, Y. Haruna, E. Imano, and et al. Oral glucose tolerance test predicts prognosis of patients with liver cirrhosis Am J Gastroenterol 101 2006 70 75
25. D. Porte Jr, and S.E. Kahn The key role of islet dysfunction in type 2 diabetes mellitus Clin Invest Med 85 1995 4 8
26. M.A. Abdul-Ghani, D. Tripathy, and R.A. DeFronzo Contributions of β-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose Diabetes Care 29 2006 1130 1139
27. G. Bianchi, G. Marchesini, M. Zoli, E. Bugianesi, A. Fabbri, and E. Pisi Prognostic significance of diabetes in patients with cirrhosis Hepatology 20 1994 119 125
28. H. Ahmadieh, and S.T. Azar Liver disease and diabetes: association, pathophysiology, and management Diabetes Res Clin Pract 104 2014 53 62
29. M. Weir Impact of immunosuppressive regimes on post-transplant diabetes mellitus Transplant Proc 33 2001 23S 26S
30. P.R. John, and P.J. Thuluvath Outcome of liver transplantation in patients with diabetes mellitus: a case-control study Hepatology 34 2001 889 895
31. S.M. Genuth How does pioglitazone prevent progression of impaired glucose tolerance to diabetes? Diabetes 62 2013 3663 3665
32. E.G. Siegel, A. Seidenstücker, B. Gallwitz, F. Schmitz, A. Reinecke-Lüthge, G. Klöppel, and et al. Insulin secretion defects in liver cirrhosis can be reversed by glucagon-like peptide-1 J Endocrinol 164 2000 13 19