Downregulation of CCR5 inhibits the proliferation and invasion of cervical cancer cells and is regulated by microRNA-107

Experimental and Therapeutic Medicine

Volumn 11, Issue 2, 2016, Pages 503-509

  Che, Li Fan ^a   Shao, Su Fang ^a   Wang, Li Xin ^a  

^a YIDU CENTRAL HOSPITAL OF WEIFANG   (China)

Author keywords

C C chemokine receptor type 5; Human cervical cancer; Invasion; MicroRNA 107

Indexed keywords

CHEMOKINE RECEPTOR CCR5; MICRORNA 107; RED FLUORESCENT PROTEIN; SMALL INTERFERING RNA;

ARTICLE; CELL GROWTH; CELL INVASION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUCIFERASE ASSAY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

EID: 84951003780     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2911     Document Type: Article

References (25)

1. Bedkowska GE, Ławicki S and Szmitkowski M: Molecular markers of carcinogenesis in the diagnostics of cervical cancer. Postepy Hig Med Dosw (Online) 63: 99-105, 2009 (In Polish).
2. Rajkumar T, Sabitha K, Vijayalakshmi N, Shirley S, Bose MV, Gopal G and Selvaluxmy G: Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer 11: 80, 2011.
3. Hu X, Schwarz JK, Lewis JS Jr, Huettner PC, Rader JS, Deasy JO, Grigsby PW and Wang X: A microRNA expression signature for cervical cancer prognosis. Cancer Res 70: 1441-1448, 2010.
4. Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK and Shen CY: PIK3CA as an oncogene in cervical cancer. Oncogene 19: 2739-2744, 2000.
5. Su TH, Chang JG, Perng LI, Chang CP, Wei HJ, Wang NM and Tsai CH: Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer. Gynecol Oncol 76: 193-199, 2000.
6. Ben-Baruch A, Michiel DF and Oppenheim JJ: Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 270: 11703-11706, 1995.
7. Cyster JG: Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs. J Exp Med 189: 447-450, 1999.
8. Cyster JG: Chemokines and cell migration in secondary lymphoid organs. Science 286: 2098-2102, 1999.
9. Luboshits G, Shina S, Kaplan O, Engelberg S, Nass D, Lifshitz-Mercer B, Chaitchik S, Keydar I and Ben-Baruch A: Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res 59: 4681-4687, 1999.
10. Mrowietz U, Schwenk U, Maune S, Bartels J, Küpper M, Fichtner I, Schröder JM and Schadendorf D: The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice. Br J Cancer 79: 1025-1031, 1999.
11. Robinson SC, Scott KA, Wilson JL, Thompson RG, Proudfoot AE and Balkwill FR: A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res 63: 8360-8365, 2003.
12. Ng-Cashin J, Kuhns JJ, Burkett SE, Powderly JD, Craven RR, van Deventer HW, Kirby SL and Serody JS: Host absence of CCR5 potentiates dendritic cell vaccination. J Immunol 170: 4201-4208, 2003.
13. van Deventer HW, O'Connor W Jr, Brickey WJ, Aris RM, Ting JP and Serody JS: C-C chemokine receptor 5 on stromal cells promotes pulmonary metastasis. Cancer Res 65: 3374-3379, 2005.
14. Son JH, Kong TW, Kim SH, Paek J, Chang SJ, Lee EJ and Ryu HS: Prediction of lymph node metastasis in patients with apparent early endometrial cancer. Obstet Gynecol Sci 58: 385-390, 2015.
15. Wang J, He Q, Shao YG and Ji M: Chemokines fluctuate in the progression of primary breast cancer. Eur Rev Med Pharmacol Sci 17: 596-608, 2013.
16. Lin S, Wan S, Sun L, Hu J, Fang D, Zhao R, Yuan S and Zhang L: Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Sci 103: 904-912, 2012.
17. Mango RL, Wu QP, West M, McCook EC, Serody JS and van Deventer HW: C-C chemokine receptor 5 on pulmonary mesenchymal cells promotes experimental metastasis via the induction of erythroid differentiation regulator 1. Mol Cancer Res 12: 274-282, 2014.
18. Singh H, Sachan R, Jain M and Mittal B: CCR5-Delta32 polymorphism and susceptibility to cervical cancer: Association with early stage of cervical cancer. Oncol Res 17: 87-91, 2008.
19. Wang L, Chang L, Li Z, Gao Q, Cai D, Tian Y, Zeng L and Li M: miR-99a and -99b inhibit cervical cancer cell proliferation and invasion by targeting mTOR signaling pathway. Med Oncol 31: 934, 2014.
20. Wen SY, Lin Y, Yu YQ, Cao SJ, Zhang R, Yang XM, Li J, Zhang YL, Wang YH, Ma MZ, et al: miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer. Oncogene 34: 717-725, 2015.
21. Zhou C, Li G, Zhou J, Han N, Liu Z and Yin J: miR-107 activates ATR/Chk1 pathway and suppress cervical cancer invasion by targeting MCL1. PLoS One 9: e111860, 2014.
22. Roldo C, Missiaglia E, Hagan JP, Falconi M, Capelli P, Bersani S, Calin GA, Volinia S, Liu CG, Scarpa A, et al: MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol 24: 4677-4684, 2006.
23. Takahashi Y, Forrest AR, Maeno E, Hashimoto T, Daub CO and Yasuda J: MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One 4: e6677, 2009.
24. Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, et al: A microRNA targeting dicer for metastasis control. Cell 141: 1195-1207, 2010.
25. Li F, Liu B, Gao Y, Liu Y, Xu Y, Tong W and Zhang A: Upregulation of microRNA-107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1. FEBS Lett 588: 538-544, 2014.