Balance between angiotensin converting enzyme and angiotensin converting enzyme 2 in patients with chronic heart failure

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 16, Issue 3, 2015, Pages 553-558

  Wang, Jiang ^a   Li, Nan ^a   Gao, Feng ^a   Song, Rong ^a   Zhu, Shanjun ^a   Geng, Zhaohua ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

angiotensin converting enzyme; angiotensin converting enzyme 2; angiotensin II; Chronic heart failure; renin angiotensin aldosterone system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; ACE PROTEIN, HUMAN;

ACE GENE; ACE2 GENE; ADULT; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART MUSCLE; HUMAN; HUMAN TISSUE; ISCHEMIC CARDIOMYOPATHY; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; AGED; CHRONIC DISEASE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED;

ADULT; AGED; BLOTTING, WESTERN; CHRONIC DISEASE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; RNA, MESSENGER;

EID: 84950314603     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320315576257     Document Type: Article

References (28)

1. Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000; 87: E1-E9.
2. Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensinconverting enzyme-cloning and functional expression as a captoprilinsensitive carboxypeptidase. J Biol Chem 2000; 275: 33238-33243.
3. Grobe JL, Mecca AP, Lingis M, et al. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). Am J Physiol Heart. Circ Physiol 2007; 292: H736-H742.
4. Huentelman MJ, Grobe JL, Vazquez J, et al. Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Exp Physiol 2005; 90: 783-790.
5. Crackower MA, Sarao R, Oudit GY, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002; 417: 822-828.
6. Ohtsuki M, Morimoto SI, Izawa H, et al. Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. Int J Cardiol 2010; 145: 333-334.
7. Goulter AB, Goddard MJ, Allen JC, et al. ACE2 gene expression is up-regulated in the human failing heart. BMC Med 2004; 2: 19
8. Batlle M, Roig E, Perez-Villa F, et al. Increased expression of the renin-angiotensin system and mast cell density but not of angiotensin-converting enzyme II in late stages of human heart failure. J Heart Lung Transplant 2006; 25: 1117-1125.
9. Ferreira AJ, Jacoby BA, Araujo CA, et al. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol 2007; 292: H1113-H1119.
10. Santos RA, Castro CH, Gava E, et al. Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice. Hypertension 2006; 47: 996-1002.
11. Simoes e, Silva AC, Pinheiro SV, Pereira RM, et al. The therapeutic potential of angiotensin-(1-7) as a novel renin-angiotensin system mediator. Mini Rev Med Chem 2006; 6: 603-609.
12. Chappel MC, Ferrario CM., ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin-(1-7). Kidney Int 2006; 70: 8-10.
13. Yamamoto K, Ohishi M, Katsuya T, et al. Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension 2006; 47: 718-726.
14. Bodiga S, Zhong JC, Wang W, et al. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res 2011; 91: 151-161.
15. Patel VB, Bodiga S, Fan D, et al. Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice. Hypertension 2012; 59: 1195-1203.
16. Oudit GY, Kassiri Z, Patel MP, et al. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res 2007; 75: 29-39.
17. Song B, Zhang ZZ, Zhong JC, et al. Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway. Circ J 2013; 77: 2997-3006.
18. Kassiri Z, Zhong J, Guo D, et al. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail 2009; 2: 446-455.
19. Kim MA, Yang D, Kida K, et al. Effects of ACE2 inhibition in the post-myocardial infarction heart. J Card Fail 2010; 16: 777-785.
20. Zhao YX, Yin HQ, Yu QT, et al. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. Hum Gene Ther 2010; 21: 1545-1554.
21. DerSarkissian S, Grobe JL, Yuan L, et al. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. Hypertension 2008; 51: 712-718.
22. Grobe JL, DerSarkissian S, Stewart JM, et al. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts. Clin Sci (Lond) 2007; 113: 357-364.
23. Zhong J, Basu R, Guo D, et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation 2010; 122: 717-728.
24. Burrell LM, Risvanis J, Kubota E, et al. Myocardial infarction increases ACE2 expression in rat and humans. Eur Heart J 2005; 26: 369-375.
25. Shao Z, Shrestha K, Borowski AG, et al. Increasing serum soluble angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure. J Card Fail 2013, 19: 605-610.
26. Epelman S, Shrestha K, Troughton RW, et al. Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. J Card Fail 2009; 15: 565-571.
27. Epelman S, Tang WH, Chen SY, et al. Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J Am Coll Cardiol 2008; 52: 750-754.
28. Ortiz-Pérez JT, Riera M, Bosch X, et al. Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study. PLoS One 2013; 8: e61695. Doi: 10.1371/journal.pone.0061695.