Algal toxin impairs sea lion memory and hippocampal connectivity, with implications for strandings

Science

Volumn 350, Issue 6267, 2015, Pages 1545-1547

  Cook, Peter F ^a,b   Reichmuth, Colleen ^b   Rouse, Andrew A ^b   Libby, Laura A ^c   Dennison, Sophie E ^d   Carmichael, Owen T ^e   Kruse Elliott, Kris T ^d   Bloom, Josh ^d   Singh, Baljeet ^c   Fravel, Vanessa A ^f   Barbosa, Lorraine ^f   Stuppino, Jim J ^d   Van Bonn, William G ^g   Gulland, Frances M D ^f   Ranganath, Charan ^c  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d AnimalScan Advanced Veterinary Imaging   (United States)

^e PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^f THE MARINE MAMMAL CENTER   (United States)

^g Shedd Aquarium   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOMOIC ACID; NEUROTOXIN; KAINIC ACID; MARINE TOXIN;

ALGAL BLOOM; MEMORY; PINNIPED; STRANDING; TOXICITY; TOXIN;

ALGAL BLOOM; ARTICLE; BRAIN DAMAGE; BRAIN SIZE; CONTROLLED STUDY; FORAGING; HIPPOCAMPUS; LONG TERM EXPOSURE; MEMORY DISORDER; NERVE CELL NETWORK; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OTARIIDAE; PRIORITY JOURNAL; SPATIAL MEMORY; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; EUTROPHICATION; METABOLISM; PHYSIOLOGY; THALAMUS;

ALGAE; ANIMALIA; OTARIIDAE;

ANIMALS; EUTROPHICATION; HIPPOCAMPUS; KAINIC ACID; MARINE TOXINS; NEUROTOXINS; SEA LIONS; SPATIAL MEMORY; THALAMUS;

EID: 84950264095     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac5675     Document Type: Article

References (18)

1. C. A. Scholin et al., Nature 403, 80-84 (2000).
2. M. W. Silver et al., Proc. Natl. Acad. Sci. U.S.A. 107, 20762-20767 (2010).
3. T. Goldstein et al., Proc. Biol. Sci. 275, 267-276 (2008).
4. P. A. Silvagni, L. J. Lowenstine, T. Spraker, T. P. Lipscomb, F. M. D. Gulland, Vet. Pathol. 42, 184-191 (2005).
5. J. O'Keefe, "Nobel lecture: Spatial cells in the hippocampal formation" (Nobel Media AB, 2014); www.nobelprize.org/nobel-prizes/medicine/laureates/ 2014/okeefe-lecture.html.
6. N. J. Fortin, K. L. Agster, H. B. Eichenbaum, Nat. Neurosci. 5, 458-462 (2002).
7. M. J. Weise, D. P. Costa, R. M. Kudela, Geophys. Res. Lett. 33, L22S10 (2006).
8. K. Thomas, J. T. Harvey, T. Goldstein, J. Barakos, F. M. D. Gulland, Mar. Mamm. Sci. 26, 36-52 (2010).
9. V. D. Bohbot et al., Neuropsychologia 36, 1217-1238 (1998).
10. M. B. Moser, E. I. Moser, Hippocampus 8, 608-619 (1998).
11. W. W. Roberts, W. N. Dember, M. Brodwick, J. Comp. Physiol. Psychol. 55, 695-700 (1962).
12. S. B. Floresco, J. K. Seamans, A. G. Phillips, J. Neurosci. 17, 1880-1890 (1997).
13. H. Eichenbaum, Nat. Rev. Neurosci. 1, 41-50 (2000).
14. D. S. Olton, J. A. Walker, F. H. Gage, Brain Res. 139, 295-308 (1978).
15. J. M. Parent et al., J. Neurosci. 17, 3727-3738 (1997).
16. B. Biswal, F. Z. Yetkin, V. M. Haughton, J. S. Hyde, Magn. Reson. Med. 34, 537-541 (1995).
17. O. I. Lyamin, I. S. Chetyrbok, Neurosci. Lett. 143, 263-266 (1992).
18. S. C. Doney et al., Ann. Rev. Mar. Sci. 4, 11-37 (2012).