Treatment and outcome of thrombolysis-related hemorrhage: A multicenter retrospective study

JAMA Neurology

Volumn 72, Issue 12, 2015, Pages 1451-1457

  Yaghi, Shadi ^a,b   Boehme, Amelia K ^a   Dibu, Jamil ^c   Guerrero, Christopher R Leo ^d   Ali, Syed ^d   Martin Schild, Sheryl ^f   Sands, Kara A ^g   Noorian, Ali Reza ^e,h   Blum, Christina A ⁱ   Chaudhary, Shuchi ^j   Schwamm, Lee H ^k   Liebeskind, David S ^h   Marshall, Randolph S ^a   Willey, Joshua Z ^a  

^a Department of Medicine   (United States)

^b BROWN UNIVERSITY   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^j UNIVERSITY OF OKLAHOMA   (United States)

^k MASSACHUSETTS GENERAL HOSPITAL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE; AMINOCAPROIC ACID; BLOOD CLOTTING FACTOR 8 CRYOPRECIPITATE; FIBRINOGEN; FRESH FROZEN PLASMA; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; VITAMIN K GROUP; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CONTROLLED STUDY; DECOMPRESSIVE CRANIECTOMY; FEMALE; FIBRINOGEN BLOOD LEVEL; HEALTH CARE FACILITY; HEMATOMA; HUMAN; HYPOFIBRINOGENEMIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE SCORE; OUTCOME ASSESSMENT; PATIENT MONITORING; PRIORITY JOURNAL; RATING SCALE; RETROSPECTIVE STUDY; SYMPTOMATIC INTRACEREBRAL HEMORRHAGE; THROMBOCYTE TRANSFUSION; UNITED STATES; ADOLESCENT; CEREBRAL HEMORRHAGE; CHILD; CLINICAL TRIAL; COMPUTED TOMOGRAPHY SCANNER; FOLLOW UP; HOSPITAL MORTALITY; MIDDLE AGED; MULTICENTER STUDY; STROKE; TIME FACTOR; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CEREBRAL HEMORRHAGE; CHILD; FEMALE; FOLLOW-UP STUDIES; HEMATOMA; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STROKE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY SCANNERS, X-RAY COMPUTED; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

EID: 84950261869     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2015.2371     Document Type: Article

References (19)

1. Jauch EC, Saver JL, Adams HP Jr, et al; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Peripheral Vascular Disease; Council on Clinical Cardiology. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3): 870-947.
2. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333(24): 1581-1587.
3. Cucchiara B, Tanne D, Levine S.R., Demchuk AM, Kasner S. A risk score to predict intracranial hemorrhage after recombinant tissue plasminogen activator for acute ischemic stroke. J Stroke Cerebrovasc Dis. 2008;17(6): 331-333.
4. Lou M, Safdar A, Mehdiratta M., et al. The HAT score: a simple grading scale for predicting hemorrhage after thrombolysis. Neurology. 2008; 71(18): 1417-1423.
5. Mazya M, Egido JA, Ford G.A., et al; SITS Investigators. Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score. Stroke. 2012;43(6): 1524-1531.
6. McMeekin P, Flynn D, Ford G.A., Rodgers H., Thomson RG. Validating the stroke-thrombolytic predictive instrument in a population in the United kingdom. Stroke. 2012;43(12): 3378-3381.
7. Strbian D, Engelter S, Michel P., et al. Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score. Ann Neurol. 2012;71(5): 634-641.
8. Goldstein JN, Marrero M, Masrur S., et al. Management of thrombolysis-associated symptomatic intracerebral hemorrhage. Arch Neurol. 2010;67(8): 965-969.
9. Wahlgren N, Ahmed N, Dávalos A, et al; SITS-MOST investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007; 369(9558): 275-282.
10. Gumbinger C, Gruschka P, Böttinger M, et al. Improved prediction of poor outcome after thrombolysis using conservative definitions of symptomatic hemorrhage. Stroke. 2012;43(1): 240-242.
11. Anderson CS, Huang Y, Wang J.G., et al; INTERACT Investigators. Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT): a randomised pilot trial. Lancet Neurol. 2008;7(5): 391-399.
12. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology. 2006;105(1): 198-208.
13. Brott T, Broderick J, Kothari R., et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997;28(1): 1-5.
14. Yaghi S, Eisenberger A, Willey JZ Symptomatic intracerebral hemorrhage in acute ischemic stroke after thrombolysis with intravenous recombinant tissue plasminogen activator: a review of natural history and treatment. JAMA Neurol. 2014;71(9): 1181-1185.
15. Brouwers HB, Chang Y, Falcone G.J., et al. Predicting hematoma expansion after primary intracerebral hemorrhage. JAMA Neurol. 2014;71(2): 158-164.
16. Kuramatsu JB, Gerner ST, Schellinger P.D., et al. Anticoagulant reversal, blood pressure levels, and anticoagulant resumption in patients with anticoagulation-related intracerebral hemorrhage. JAMA. 2015;313(8): 824-836.
17. Mahaffey KW, Granger CB, Sloan M.A., et al; GUSTO Investigators. Neurosurgical evacuation of intracranial hemorrhage after thrombolytic therapy for acute myocardial infarction: experience from the GUSTO-I trial. Am Heart J. 1999;138(3, pt 1): 493-499.
18. Hemphill JC III, Greenberg SM, Anderson CS, et al; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46(7): 2032-2060.
19. Wang L, Fan W, Cai P., et al. Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice. Ann Neurol. 2013;73(2): 189-198.