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Volumn 11, Issue 1, 2016, Pages 122-128

The promise and pitfalls of long-acting injectable agents for HIV prevention

Author keywords

cabotegravir; HIV 1; long acting injectable antiretroviral; preexposure prophylaxis; rilpivirine

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CABOTEGRAVIR; CORTICOTROPIN; HYDROCORTISONE; RILPIVIRINE; DELAYED RELEASE FORMULATION;

EID: 84950249101     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000219     Document Type: Review
Times cited : (94)

References (28)
  • 1
    • 78650549662 scopus 로고    scopus 로고
    • Preexposure chemoprophylaxis for HIV preventioninmenwhohavesex withmen
    • Grant R, Lama J, Anderson P, et al. Preexposure chemoprophylaxis for HIV preventioninmenwhohavesex withmen. NEngl JMed2010;363:2587-2599.
    • (2010) NEngl JMed , vol.363 , pp. 2587-2599
    • Grant, R.1    Lama, J.2    Anderson, P.3
  • 2
    • 84906793896 scopus 로고    scopus 로고
    • Uptake of preexposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: A cohort study
    • Grant R, Anderson P, McMahan V, et al. Uptake of preexposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet 2014; 14:820-829.
    • (2014) Lancet , vol.14 , pp. 820-829
    • Grant, R.1    Anderson, P.2    McMahan, V.3
  • 3
  • 4
    • 84928406861 scopus 로고    scopus 로고
    • Pragmatic open-label randomised trial of preexposure prophylaxis: The proud study
    • online dx doi
    • McCormack S, Dunn D, Desai, M. et al. Pragmatic open-label randomised trial of preexposure prophylaxis: The PROUD study Lancet online 2015 dx. doi.
    • (2015) Lancet
    • McCormack, S.1    Dunn, D.2    Desai, M.3
  • 5
    • 84864505868 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    • Baeten J, Donnell D, Ndase P, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 2012; 367:399-410.
    • (2012) N Engl J Med , vol.367 , pp. 399-410
    • Baeten, J.1    Donnell, D.2    Ndase, P.3
  • 6
    • 84886804053 scopus 로고    scopus 로고
    • Exploring concentration response in HIV preexposure prophylaxis to optimize clinical care and trial design
    • Hendrix C. Exploring concentration response in HIV preexposure prophylaxis to optimize clinical care and trial design. Cell 2013; 155:515-518.
    • (2013) Cell , vol.155 , pp. 515-518
    • Hendrix, C.1
  • 8
    • 84866283847 scopus 로고    scopus 로고
    • Emtricitabine-tenofovir concentrations and preexposure prophylaxis efficacy in men who have sex with men
    • Anderson P, Glidden D, Liu A, et al. Emtricitabine-tenofovir concentrations and preexposure prophylaxis efficacy in men who have sex with men. Sci Transl Med 2012; 4:151ra125.
    • (2012) Sci Transl Med , vol.4 , pp. 151ra125
    • Anderson, P.1    Glidden, D.2    Liu, A.3
  • 9
    • 84950274249 scopus 로고    scopus 로고
    • Predicting effective truvada prep dosing strategies with a novel pk-pd model incorporating tissue active metabolites and endogenous nucleotides (en) [abstract oa22. 06 lb]
    • 28-31 October; Cape Town, South Africa
    • Cottrell M, Yang K, Prince H, et al. Predicting effective truvada PrEP dosing strategies with a novel PK-PD model incorporating tissue active metabolites and endogenous nucleotides (EN) [Abstract OA22. 06 LB]. HIV Research for Prevention (HIV R4P); 28-31 October 2014; Cape Town, South Africa.
    • (2014) HIV Research for Prevention (HIV R4P
    • Cottrell, M.1    Yang, K.2    Prince, H.3
  • 10
    • 83155177076 scopus 로고    scopus 로고
    • Penetration of tenofovir and emtricitabine in mucosal tissues: Implications for prevention of HIV-1 transmission
    • Patterson K, Prince H, Kraft E, et al. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med 2011; 3:112re114.
    • (2011) Sci Transl Med , vol.3 , pp. 112re114
    • Patterson, K.1    Prince, H.2    Kraft, E.3
  • 11
    • 84931273616 scopus 로고    scopus 로고
    • Pharmacokinetics of longacting tenofoviralafenamide (gs-7340) subdermal implant for HIV prophylaxis
    • Gunawardana M, Remedios-ChanM, Miller C, et al. Pharmacokinetics of longacting tenofoviralafenamide (GS-7340) subdermal implant for HIV prophylaxis. Antimicrob Agents Chemother 2015; AAC-00656.
    • (2015) Antimicrob Agents Chemother , pp. AAC-00656
    • Gunawardana, M.1    Remedios-Chan, M.2    Miller, C.3
  • 12
    • 84896769378 scopus 로고    scopus 로고
    • Long-Acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus
    • Andrews C, Spreen W,Mohri H, et al. Long-Acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus. Science 2014; 343:1151-1154.
    • (2014) Science , vol.343 , pp. 1151-1154
    • Andrews, C.1    Spreen, W.2    Mohri, H.3
  • 13
    • 84950301595 scopus 로고    scopus 로고
    • Correlation of in vivo cabotegravir concentration and prevention of siv in macaques [abstract 966lb]
    • 23-26 February; Seattle, Washington
    • Spreen W, Lowry A, Pal R, et al. Correlation of in vivo cabotegravir concentration and prevention of SIV in macaques [Abstract 966LB]. 22nd Conference on Retroviruses and Opportunistic Infections (CROI); 23-26 February 2015; Seattle, Washington.
    • (2015) 22nd Conference on Retroviruses and Opportunistic Infections (CROI
    • Spreen, W.1    Lowry, A.2    Pal, R.3
  • 14
    • 84927638575 scopus 로고    scopus 로고
    • 744 and rilpivirine as two-drug oral maintenance therapy: Lai116482 (latte) week 48 results [abstract 91lb]
    • 3-6 March; Boston, Massachusetts
    • Margolis D, Brinson C, Eron J, et al. 744 and rilpivirine as two-drug oral maintenance therapy: Lai116482 (latte) week 48 results [Abstract 91LB]. 21st Conference on Retroviruses and Opportunistic Infections (CROI); 3-6 March 2014; Boston, Massachusetts.
    • (2014) 21st Conference on Retroviruses and Opportunistic Infections (CROI
    • Margolis, D.1    Brinson, C.2    Eron, J.3
  • 15
    • 84950245690 scopus 로고    scopus 로고
    • Cabotegravir and rilpivirine as 2-drug oral maintenance therapy: Latte w96 results [abstract 554lb]
    • 23-26 February; Seattle, Washington
    • Margolis D, Brinson C, Smith G, et al. Cabotegravir and rilpivirine as 2-drug oral maintenance therapy: LATTE W96 results [Abstract 554LB]. 22nd Conference on Retroviruses and Opportunistic Infections (CROI); 23-26 February 2015; Seattle, Washington.
    • (2015) 22nd Conference on Retroviruses and Opportunistic Infections (CROI
    • Margolis, D.1    Brinson, C.2    Smith, G.3
  • 16
    • 75749118495 scopus 로고    scopus 로고
    • Tmc278, a next-generation nonnucleoside reverse transcriptase inhibitor (nnrti), active against wild-type and nnrtiresistant HIV-1
    • Azijn H, Tirry I, Vingerhoets J, et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTIresistant HIV-1. Antimicrob Agent Chemother 2010; 54:718-727.
    • (2010) Antimicrob Agent Chemother , vol.54 , pp. 718-727
    • Azijn, H.1    Tirry, I.2    Vingerhoets, J.3
  • 17
    • 67650456668 scopus 로고    scopus 로고
    • Rilpivirine: A novel nonnucleoside reverse transcriptase inhibitor
    • Garvey L, Winston A. Rilpivirine: A novel nonnucleoside reverse transcriptase inhibitor. Expert Opin Investig Drugs 2009; 18:1035-1041.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1035-1041
    • Garvey, L.1    Winston, A.2
  • 18
    • 84950250095 scopus 로고    scopus 로고
    • Preclinical evaluation of tmc-278la, a long-Acting formulation of rilpivirine, demonstrates significant protection from vaginal HIV infection [abstract oa03. 01]
    • 28-31 October Cape Town, South Africa
    • Snyder O, Vincent H, Lachau-Durant S, et al. Preclinical evaluation of TMC-278LA, a long-Acting formulation of rilpivirine, demonstrates significant protection from vaginal HIV infection [Abstract OA03. 01]. HIV Research for Prevention (HIV R4P); 28-31 October 2014; Cape Town, South Africa.
    • (2014) HIV Research for Prevention (HIV R4P
    • Snyder, O.1    Vincent, H.2    Lachau-Durant, S.3
  • 19
    • 84907878697 scopus 로고    scopus 로고
    • A compartmental pharmacokinetic evaluation of long-Acting rilpivirine in HIV-negative volunteers for preexposure prophylaxis
    • Jackson A, Else L, Mesquita P, et al. A compartmental pharmacokinetic evaluation of long-Acting rilpivirine in HIV-negative volunteers for preexposure prophylaxis. Clin Pharmacol Ther 2014; 96:314-323.
    • (2014) Clin Pharmacol Ther , vol.96 , pp. 314-323
    • Jackson, A.1    Else, L.2    Mesquita, P.3
  • 20
    • 84942846401 scopus 로고    scopus 로고
    • A phase 1 open label safety, acceptability, pharmacokinetic, and pharmacodynamic study of intramuscular tmc278la (the mwri-01 study) [abstract oa27. 06 lb]
    • 28-31 October Cape Town, South Africa
    • McGowan I, Siegel A, Duffill K, et al. A phase 1 open label safety, acceptability, pharmacokinetic, and pharmacodynamic study of intramuscular TMC278LA (the MWRI-01 study) [Abstract OA27. 06 LB]. HIV Research for Prevention (HIV R4P); 28-31 October 2014; Cape Town, South Africa.
    • (2014) HIV Research for Prevention (HIV R4P
    • McGowan, I.1    Siegel, A.2    Duffill, K.3
  • 21
    • 84950294750 scopus 로고    scopus 로고
    • Selection of rilpivirine resistant HIV-1 in a seroconverter on long-Acting rilpivirine (tmc278la) from the lowest dose arm of the ssat 040 trial [abstract oa27. 01]
    • 28-31 October; Cape Town, South Africa
    • Penrose K, Parikh U, Hamanishi K, et al. Selection of rilpivirine resistant HIV-1 in a seroconverter on long-Acting rilpivirine (TMC278LA) from the lowest dose arm of the SSAT 040 trial [Abstract OA27. 01]. HIV Research for Prevention (HIV R4P); 28-31 October 2014; Cape Town, South Africa.
    • (2014) HIV Research for Prevention (HIV R4P
    • Penrose, K.1    Parikh, U.2    Hamanishi, K.3
  • 22
    • 40649085987 scopus 로고    scopus 로고
    • Hormonal contraceptive discontinuation patterns according to formulation: Investigation of associations in an administrative claims database
    • Murphy P, Brixner D. Hormonal contraceptive discontinuation patterns according to formulation: investigation of associations in an administrative claims database. Contraception 2008; 77:257-263.
    • (2008) Contraception , vol.77 , pp. 257-263
    • Murphy, P.1    Brixner, D.2
  • 23
    • 34548679894 scopus 로고    scopus 로고
    • Assessing regional differences in contraceptive discontinuation, failure and switching in Brazil
    • Leite IC, Gupta N. Assessing regional differences in contraceptive discontinuation, failure and switching in Brazil. Reprod Health 2007; 4:6.
    • (2007) Reprod Health , vol.4 , pp. 6
    • Leite, I.C.1    Gupta, N.2
  • 24
    • 84942191100 scopus 로고    scopus 로고
    • Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (latte): A randomised, phase 2b, dose-ranging trial
    • Margolis DA, Brinson CC, Smith GHR, et al. Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trial. Lancet 2015; 15:1145-1155.
    • (2015) Lancet , vol.15 , pp. 1145-1155
    • Margolis, D.A.1    Brinson, C.C.2    Smith, G.H.R.3
  • 25
    • 84943155332 scopus 로고    scopus 로고
    • Meta-Analysis of safety data from 8 clinical studies with gsk1265744 an HIV integrase inhibitor dosed orally or as injection of long-Acting parenteral nanosuspension (lap) [abstract 1752]
    • 10-13 September 2013 Denver, Colorado
    • Lou Y, Gould E, Chen S, et al. Meta-Analysis of safety data from 8 clinical studies with GSK1265744, an HIV integrase inhibitor, dosed orally or as injection of long-Acting parenteral nanosuspension (LAP) [Abstract 1752]. 53rd ICAAC Interscience Conference on Antimicrobial Agents and Chemotherapy; 10-13 September 2013; Denver, Colorado.
    • 53rd ICAAC Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Lou, Y.1    Gould, E.2    Chen, S.3
  • 26
    • 84886473877 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and monotherapy antiviral activity of gsk1265744, an HIV integrase strand transfer inhibitor
    • Spreen W, Min S, Ford S, et al. Pharmacokinetics, safety, and monotherapy antiviral activity of GSK1265744, an HIV integrase strand transfer inhibitor. HIV Clin Trials 2013; 14:192-203.
    • (2013) HIV Clin Trials , vol.14 , pp. 192-203
    • Spreen, W.1    Min, S.2    Ford, S.3
  • 27
    • 84860455337 scopus 로고    scopus 로고
    • Long-term efficacy, safety, and tolerability of rilpivirine (rpv, tmc278) in HIV type 1-infected antiretroviralnaive patients: Week 192 results from a phase iib randomized trial
    • Wilkin A, Poznaik AL, Morales-Ramirez J, et al. Long-term efficacy, safety, and tolerability of rilpivirine (RPV, TMC278) in HIV type 1-infected antiretroviralnaive patients: Week 192 results from a phase IIb randomized trial. AIDS Res Hum Retroviruses 2012; 28:437-446.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , pp. 437-446
    • Wilkin, A.1    Poznaik, A.L.2    Morales-Ramirez, J.3
  • 28
    • 84950290079 scopus 로고    scopus 로고
    • Ethical considerations regarding oral preexposure prophylaxis in HIV prevention trials
    • Sugarman J. Ethical considerations regarding oral preexposure prophylaxis in HIV prevention trials. Curr Opin HIV AIDS 2016; 11:109-115.
    • (2016) Curr Opin HIV AIDS , vol.11 , pp. 109-115
    • Sugarman, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.